M. Docteur FREDERIC TOUSSAINT

Bibliographie

• Hennebont de la lumière à l'ombre : 1660-1780

  2017

  Thèse

• Activity of the purified plant ABC transporter NtPDR1 is stimulated by diterpenes and sesquiterpenes involved in constitutive and induced defenses

  2017

  ArticleJournal of Biological Chemistry

• Purification and biochemical characterization of NpABCG5/NpPDR5, a plant pleiotropic drug resistance transporter expressed in Nicotiana tabacum BY-2 suspension cells

  2017

  ArticleBiochemical Journal

• Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: Correlating magnetic resonance imaging findings with disease severity

  2005

  ArticleArthritis and Rheumatism

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation des cabinets

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieux de consultation

• SOCIETE CIVILE PROFESSIONNELLE DES DOCTEURS FREDERIC TOUSSAINT NORBERT SAULIERE DOMINIQUE OREFICE MARINE FACCIN ET JULIEN GROSSE

  200 RUE ANDRE BISIAUX, 54320 Maxéville

  Libéral
  212 m244 m244 m244 m

  © OpenStreetMap · Photos Wikimedia Commons (CC)

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• SERVICE DE SOINS SNCF

  5B Rue SAINT-LEON, 54000 Nancy

  ☎ 0383221011Hospitalier🏥 Voir cet établissement
  20 m21 m21 m22 m

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Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity

  Arthritis and rheumatism · 2005

  📚 226 citations🎯 RCR 6.29Top 5% NIH

  Lire l'abstract Crossref ↓

  AbstractObjectiveTo determine the magnetic resonance imaging (MRI), macroscopic, and microscopic characteristics of synovial membrane inflammation, to study the relationship between disease severity and the degree of synovial inflammation on MRI and on macroscopic and microscopic examination, and to look for colocalization of chondral lesions and synovial inflammation.MethodsThirty‐nine patients with knee osteoarthritis (OA) were classified into 2 groups according to the severity of cartilage lesions as revealed by chondroscopy. Group 1 (n = 14) had mild cartilage lesion(s) without exposure of subchondral bone. Group 2 (n = 25) had severe cartilage lesion(s) with focal or diffuse exposure of subchondral bone. Synovitis was evaluated on T1‐weighted MRI sequences according to the degree of synovial thickening on a 4‐point scale (ranging from 0 to 3) in 5 regions of interest. Synovial membrane was macroscopically scored, and biopsies were performed on the 5 preselected sites for histologic scoring.ResultsThe mean ± SD synovial thickening score on MRI was 1.55 ± 0.90, with no significant difference between groups 1 and 2. Intra‐ and interobserver reproducibility of the total synovial score was excellent, and interobserver reproducibility of the MRI grade was good. Synovitis was diffuse and associated with chondral lesions only in the medial femorotibial compartment (r = 0.49, P = 0.001). The degree of synovial thickening on MRI correlated with qualitative macroscopic analysis (rs = 0.58, P < 0.001) and with microscopic features (synovial lining cells [rs = 0.23, P < 0.007], surface fibrin deposition [rs = 0.12, P < 0.01], fibrosis [rs = 0.31, P < 0.006], edema [rs = 0.17, P = 0.07], congestion [rs = 0.30, P < 0.005], and infiltration [rs = 0.46, P < 0.0001]). Fibrin and infiltration parameters were more severe in end‐stage disease (P = 0.009 and P = 0.02, respectively).ConclusionSynovitis may be present from the onset of OA and may be evaluated on MRI. MRI evaluation of synovitis could be used to classify OA patients in clinical trials and could help to identify those who could benefit from synovium‐targeted therapy.

• 2

  Activity of the purified plant ABC transporter NtPDR1 is stimulated by diterpenes and sesquiterpenes involved in constitutive and induced defenses

  The Journal of biological chemistry · 2017

  📚 44 citations🎯 RCR 2.04🔓 Open Access📄 PDF gratuit ↗
• 3

  Sustainable responses in metastatic melanoma patients with and without brain metastases after elective discontinuation of anti-PD1-based immunotherapy due to complete response

  European journal of cancer (Oxford, England : 1990) · 2021

  📚 22 citations🎯 RCR 1.05🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (13) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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