Docteur JEAN ROQUES

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Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• Albi. Les Lapérousiens en assemblée générale - ladepeche.fr

  📰 ladepeche.fr · 04/04/2025

  <a href="https://news.google.com/rss/articles/CBMikAFBVV95cUxPMEcySGZFNXRUMFhXX3YxdG5DZ0NyS1RzUDVUOWZZaTFaM1BXRWNxR2RXQ0pQQ296bnFFMU83ZGlQUnk4Smd5ZktibjhFUlBNRExmb3lWRjk2YzVPUVFHYnJnMkszYV82WUZEeXdNWmVSRnJwa2F5T1MzSXhvOEpDc1hZekVRQ0E3elJZMUZnbnI?oc=5" target="_blank">Albi. Les Lapérousiens en assemb

Top publications · les plus citées

• 1

  Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells

  Journal of immunology (Baltimore, Md. : 1950) · 2012

  📚 12 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract To maintain tolerance, autoreactive B cells must regulate signal transduction from the BCR and TLRs. We recently identified that dendritic cells and macrophages regulate autoreactive cells during TLR4 activation by releasing IL-6 and soluble CD40 ligand (sCD40L). These cytokines selectively repress Ab secretion from autoreactive, but not antigenically naive, B cells. How IL-6 and sCD40L repress autoantibody production is unknown. In this work, we show that IL-6 and sCD40L are required for low-affinity/avidity autoreactive B cells to maintain tolerance through a mechanism involving receptor cross-talk between the BCR, TLR4, and the IL-6R or CD40. We show that acute signaling through IL-6R or CD40 integrates with chronic BCR-mediated ERK activation to restrict p-ERK from the nucleus and represses TLR4-induced Blimp-1 and XBP-1 expression. Tolerance is disrupted in 2-12H/MRL/lpr mice where IL-6 and sCD40L fail to spatially restrict p-ERK and fail to repress TLR4-induced Ig secretion. In the case of CD40, acute signaling in B cells from 2-12H/MRL/lpr mice is intact, but the chronic activation of p-ERK emanating from the BCR is attenuated. Re-establishing chronically active ERK through retroviral expression of constitutively active MEK1 restores tolerance upon sCD40L, but not IL-6, stimulation, indicating that regulation by IL-6 requires another signaling effector. These data define the molecular basis for the regulation of low-affinity autoreactive B cells during TLR4 stimulation; they explain how autoreactive but not naive B cells are repressed by IL-6 and sCD40L; and they identify B cell defects in lupus-prone mice that lead to TLR4-induced autoantibody production.

• 2

  High protein requirements of juvenile Atlantic wolffish, Anarhichas lupus: Effects of dietary protein levels on growth, health, and welfare

  Journal of fish biology · 2025

  📚 5 citations🎯 RCR 2.67🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  AbstractThe objective of the present study was to investigate the optimal dietary protein requirement and the effect of varying protein levels on the growth and health of juvenile, wild‐caught Atlantic wolffish, Anarhichas lupus, a promising candidate for cold‐water aquaculture diversification. Six iso‐energetic (ca. 18.3 MJ kg−1), fish meal‐based experimental diets were formulated with crude protein levels ranging from 35% to 60%, with graded increments of 5% in a 12‐week feeding trial in a recirculating aquaculture system (RAS). Weight gain, specific growth rate (SGR), and condition factor (K) were evaluated in response to dietary protein levels. Liver, muscle, and blood parameters were assessed for possible changes in protein and lipid metabolism and welfare. Overall growth was highly variable throughout the experiment on all diets, as expected for a wild population. The feed with highest in protein (60%) inclusion resulted in the highest growth rates, with an average weight gain of 37.4% ± 33.8% and an SGR of 0.31% ± 0.2% day−1. This was closely followed by feeds with 55% and 50% protein inclusion with an average weight gain of 22.9% ± 34.8% and 28.5% ± 38.3%, respectively, and an SGR of 0.18% ± 0.3% day−1 and 0.22% ± 0.3% day−1, respectively. Fish fed the high protein diets generally had increased hepatic lipid deposition (17%–18%) and reduced free fatty acid levels (3.1–6.8 μmol L−1) in the plasma relative to fish that were fed the lower protein diets (35%–45%). No effects of diet were found on plasma protein levels or muscle protein content. Furthermore, stress parameters such as plasma cortisol and glucose levels were unaffected by diet, as were plasma ghrelin levels. Overall, these results suggest that a high protein inclusion in the diet for Atlantic wolffish is required to sustain growth with a minimum protein level of 50%.

• 3

  Insights into thermal sensitivity: Effects of elevated temperature on growth, metabolic rate, and stress responses in Atlantic wolffish (Anarhichas lupus)

  Journal of fish biology · 2025

  📚 4 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  AbstractThe Atlantic wolffish (Anarhichas lupus) is a cold‐water fish with potential for aquaculture diversification. To unveil the mechanisms underlying the compromised growth in Atlantic wolffish when reared at higher temperatures, we investigated the relationship between temperature, growth rate, aerobic capacity, stress biomarkers, and gut barrier function. Juveniles acclimated to 10°C were maintained at 10°C (control) or exposed to 15°C for either 24 h (acute exposure) or 50 days (chronic exposure). Fish exposed to 15°C exhibited reduced growth, higher standard, and maximum metabolic rates compared to those at 10°C. In the chronically exposed group at 15°C, metabolic rates were lower than those of acutely exposed fish. The absolute aerobic scope exhibited no significant variation in temperatures; however, the factorial scope showed a notable reduction at 15°C in both acute and chronic exposed groups, aligning with a correlated decrease in individual growth rates. Chronic warming led to increased plasma glucose levels, indicating energy mobilization, but cortisol levels were unaffected. Furthermore, chronic warming resulted in reduced intestinal barrier function, as evidenced by increased ion permeability and a negative potential in the serosa layer. We conclude that warming elevates metabolic rates while reducing intestinal barrier function, thus increasing energy expenditure, collectively, limiting energy available for growth at this temperature from increased allostatic load. Thus, juvenile wolffish maintaining their aerobic scope under thermal stress experience slower growth. This research provides insights for improving the welfare and resilience of wolffish in aquaculture at elevated temperatures and understanding their response to increased environmental temperatures.

Publications scientifiques (6) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• SPI science prospects

  Preprint2002arXiv

  With the launch of ESA's INTEGRAL satellite in october 2002, a gamma-ray observatory will become available to the scientific community that combines imaging and spectroscopic capacities in the 20 keV to 10 MeV energy ran

• The INTEGRAL/SPI view of A0535+26 during the giant outburst of February 2011

  Preprint2015arXiv

  A0535+26 is a slowly rotating pulsar accreting from the wind of a massive Be star, and that exhibits two cyclotron absorption lines in its X-ray spectrum, at about 45 and 100 keV, respectively. Unlike similar sources, no

• INTEGRAL reloaded: spacecraft, instruments and ground system

  Preprint2021arXiv

  ESA's INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) was launched on 17 Oct 2002 at 06:41 CEST. Since then, it has been providing long, uninterrupted observations (up to about 47 hr, or 170 ksec, per satellit

• Falling film evaporation on a single tube and on a tube bundle

  Dissertation2004Lausanne, EPFL

  This study is a contribution for the improvement of horizontal falling film heat exchangers. This type of evaporator has the potential to be widely used in the petrochemical industry, for the sea water desalination, or i

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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