Mme Docteur MARIE-PIERRE PETIT

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• SELARL RHUMATO DE CHASLES

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Top publications · les plus citées

• 1

  A school-based exercise intervention elicits substantial bone health benefits: a 2-year randomized controlled trial in girls

  Pediatrics · 2003

  📚 183 citations🎯 RCR 6.06Top 6% NIH🩺 Clinique

  Lire l'abstract Crossref ↓

  Objective. Childhood weight-bearing physical activity is recognized as an important determinant of peak bone mass, and physical activity intervention may represent a feasible strategy for primary prevention of osteoporosis. Previous school-based exercise interventions have all been of <10 months in duration. We implemented a high-impact, circuit-based, jumping intervention (10 minutes, 3 times a week) over 2 school years and compared changes in bone mineral content (BMC) over 20 months (2 school years) in 9.9 ± 0.6-year-old intervention girls (N = 32) and controls (10.3 ± 0.4 years, N = 43).Methods. We measured BMC for the total body, lumbar spine, proximal femur (and femoral neck and trochanteric subregions), and lean and fat mass by dual-energy radiograph absorptiometry (Hologic QDR 4500), and height, sitting height, leg length, and weight at baseline and 20 months. We assessed Tanner stage, general physical activity, and calcium intake by questionnaire.Results. Girls were Tanner breast stage 1 to 3 at baseline. There were no significant differences in baseline or 20-month change in body size or composition, average physical activity, or calcium intake between groups. There were substantially greater gains in lumbar spine (41.7% vs 38.0%) and femoral neck (24.8% vs 20.2%) BMC in intervention than in control girls (P < .05, analysis of covariance; covariates were baseline BMC and height, change in height, physical activity, and final Tanner stage).Conclusion. Three brief sessions of high-impact exercise per week implemented over 2 consecutive years within the elementary school curriculum elicited a substantial bone mineral accrual advantage in pubertal girls.

• 2

  Community-based exercise program reduces risk factors for falls in 65- to 75-year-old women with osteoporosis: randomized controlled trial

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2002

  📚 131 citations🎯 RCR 4.61Top 9% NIH🩺 Clinique
• 3

  Bone strength measured by peripheral quantitative computed tomography and the risk of nonvertebral fractures: the osteoporotic fractures in men (MrOS) study

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011

  📚 89 citations🎯 RCR 3.50Top 13% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract Many fractures occur in individuals without osteoporosis defined by areal bone mineral density (aBMD). Inclusion of other aspects of skeletal strength may be useful in identifying at-risk subjects. We used surrogate measures of bone strength at the radius and tibia measured by peripheral quantitative computed tomography (pQCT) to evaluate their relationships with nonvertebral fracture risk. Femoral neck (FN) aBMD, measured by dual-energy X-ray absorptiometry (DXA), also was included. The study population consisted of 1143 white men aged 69+ years with pQCT measures at the radius and tibia from the Minneapolis and Pittsburgh centers of the Osteoporotic Fractures in Men (MrOS) study. Principal-components analysis and Cox proportional-hazards modeling were used to identify 21 of 58 pQCT variables with a major contribution to nonvertebral incident fractures. After a mean 2.9 years of follow-up, 39 fractures occurred. Men without incident fractures had significantly greater bone mineral content, cross-sectional area, and indices of bone strength than those with fractures by pQCT. Every SD decrease in the 18 of 21 pQCT parameters was significantly associated with increased fracture risk (hazard ration ranged from 1.4 to 2.2) independent of age, study site, body mass index (BMI), and FN aBMD. Using area under the receiver operation characteristics curve (AUC), the combination of FN aBMD and three radius strength parameters individually increased fracture prediction over FN aBMD alone (AUC increased from 0.73 to 0.80). Peripheral bone strength measures are associated with fracture risk and may improve our ability to identify older men at high risk of fracture. © 2011 American Society for Bone and Mineral Research.

Publications scientifiques (15) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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