M. Docteur FLORENCE MERLE-VINCENT

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• CABINET DU DR FLORENCE MERLE-VINCENT

  CENTRE DE RHUMATOLOGIE NORD ISERE — 40 AVENUE DES ALPES, 38300 Bourgoin-Jallieu

  ☎ 0428350103Libéral
  80 m116 m166 m171 m

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Top publications · les plus citées

• 1

  Anti-tumor necrosis factor alpha therapy in fifteen patients with AA amyloidosis secondary to inflammatory arthritides: a followup report of tolerability and efficacy

  Arthritis and rheumatism · 2003

  📚 159 citations🎯 RCR 4.66Top 9% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  AbstractObjectiveBecause anti–tumor necrosis factor α (anti‐TNF) has emerged as a highly effective treatment for numerous inflammatory arthritides, which are a common cause of AA amyloidosis, we retrospectively evaluated the safety and efficacy of anti‐TNF in a nationwide study.MethodsThe rheumatology departments of all French teaching hospitals were contacted by mail to obtain the files of patients with histologically proven secondary AA amyloidosis and renal involvement who were treated with anti‐TNF. Efficacy was assessed as a sustained decrease in 24‐hour proteinuria and a stable/improved glomerular filtration rate (GFR).ResultsAmong the 15 patients studied, the 24‐hour proteinuria was 4.5 ± 3.6 gm (mean ± SD), creatininemia was 178.4 ± 74.9 μmoles/liter, and GFR was 46 ± 23 ml/minute before starting anti‐TNF. Ten patients received infliximab, 4 received etanercept, and 1 received both types of treatment. The mean followup was 10.4 months. No severe adverse events were recorded; one episode of herpes zoster in the first branch of the trigeminal nerve occurred after one infusion of infliximab. Amyloidosis progressed in 7 patients and was stabilized in 5 patients. Three patients (receiving infliximab alone, infliximab plus methotrexate [MTX], or etanercept plus MTX) experienced rapid, dramatic, and sustained decreases in proteinuria (≥80%), with the GFR increasing 15–78%.ConclusionAnti‐TNF was well‐tolerated and safe in the 15 patients with AA amyloidosis and renal involvement. The pathogenic role of TNF in AA amyloidosis, the sustained proteinuria decrease in 3 patients, and the stabilization of renal parameters in 5 other patients make anti‐TNF a promising candidate to treat AA amyloidosis secondary to inflammatory arthritides.

• 2

  Measurement of radiographic joint space width in the tibiofemoral compartment of the osteoarthritic knee: comparison of standing anteroposterior and Lyon schuss views

  Arthritis and rheumatism · 2003

  📚 145 citations🎯 RCR 4.64Top 9% NIH🩺 Clinique

  Lire l'abstract Crossref ↓

  AbstractObjectiveTo evaluate progression of joint space narrowing in radiographs of osteoarthritic (OA) knees imaged in both the standing anteroposterior (AP) and the Lyon schuss positions, using alternative methods to measure joint space width (JSW).MethodsStanding AP (extended view) and Lyon schuss (posteroanterior [PA] view, with 20–30° of flexion) radiographic images of 58 OA knees were obtained twice (at baseline and 2 years later). With both methods, fluoroscopy was used to align the anterior and posterior margins of the medial or lateral tibial plateau with the central x‐ray beam. Minimum JSW, mean JSW, and joint space area (JSA) of the medial or lateral femorotibial joint space were measured using a new digital image analysis system. The effects of knee flexion versus extension and parallel versus nonparallel tibial plateau alignment were evaluated with respect to the reproducibility of JSW in repeated examinations (intraclass correlation coefficient [ICC]), the mean of within‐knee standard deviations of repeated measurements (SDm), and the sensitivity to changes in JSW in serial radiographs (standardized response mean [SRM]).ResultsThe performance of the new software, as assessed by the reproducibility of repeated measurements of minimum JSW on the same image, was excellent in both the standing AP (ICC = 0.98) and Lyon schuss radiographs (2 SDm = 0.5 mm, ICC = 0.98). The reproducibility in different radiographs of the same knee was not evaluated. However, over 2 years, the mean (± SD) decrease in the minimum JSW of OA knees was 0.17 ± 0.75 mm in standing AP radiographs (P not significant) and 0.24 ± 0.50 mm in Lyon schuss views (P = 0.007), with SRMs of 0.23 and 0.48, respectively. The quality of alignment of the tibial plateau was satisfactory (<1 mm between anterior and posterior margins of the medial tibial plateau) in 66% of the pairs of Lyon schuss radiographs and in 57% of the pairs of standing AP radiographs. In the Lyon schuss radiographs, SRM was highly dependent on tibial plateau alignment. Minimum JSW was more sensitive to change than was mean JSW or JSA, in paired Lyon schuss radiographs that exhibited satisfactory alignment.ConclusionCompared with the standing AP radiograph, PA imaging of the knee in 20–30° flexion (the schuss position) increases the reproducibility of radiographic JSW measurements in OA knees and the sensitivity to change in JSW in serial radiographs. Sensitivity to change in minimum JSW is notably increased by aligning the medial tibial plateau with the central x‐ray beam in the Lyon schuss radiograph.

• 3

  Factors predicting patient satisfaction 2 years after total knee arthroplasty for osteoarthritis

  Joint bone spine · 2011

  📚 89 citations🎯 RCR 4.54Top 9% NIH

Publications scientifiques (8) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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