Docteur Catherine MARCHAND

Bibliographie

• Behavioral tests that reveal long-term deficits after permanent focal cerebral ischemia in mouse

  2019

  ArticleBehavioural Brain Research

• Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice

  2018

  ArticleMolecular Neurobiology

• Recombinant tissue plasminogen activator enhances microparticle release from mouse brain-derived endothelial cells through plasmin

  2016

  ArticleJournal of the Neurological Sciences

• Prevention of rt-PA induced blood–brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice

  2013

  ArticleExperimental Neurology

• Progesterone Receptors: A Key for Neuroprotection in Experimental Stroke

  2012

  ArticleEndocrinology

• Combined therapy with PJ34, a poly(ADP‐ribose)polymerase inhibitor, reduces tissue plasminogen activator‐induced hemorrhagic transformations in cerebral ischemia in mice

  2012

  ArticleFundamental & Clinical Pharmacology

• Simvastatin in traumatic brain injury: Effect on brain edema mechanisms

  2011

  ArticleCritical Care Medicine

• Long-term histological and behavioural characterisation of a collagenase-induced model of intracerebral haemorrhage in rats

  2010

  ArticleJournal of Neuroscience Methods

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

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  10 Rue DU CHAMP GAILLARD, 78303 Poissy

  ☎ 0139274050Hospitalier🏥 Centre CH ↗🏥 Voir cet établissement

Tarifs & secteur de conventionnement

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Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Addressing the crisis of GP recruitment and retention: a systematic review

  The British journal of general practice : the journal of the Royal College of General Practitioners · 2017

  📚 168 citations🎯 RCR 13.35Top 2% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  BackgroundThe numbers of GPs and training places in general practice are declining, and retaining GPs in their practices is an increasing problem.Aim To identify evidence on different approaches to retention and recruitment of GPs, such as intrinsic versus extrinsic motivational determinants.Design and setting Synthesis of qualitative and quantitative research using seven electronic databases from 1990 onwards (Medline, Embase, Cochrane Library, Health Management Information Consortium [HMIC], Cumulative Index to Nursing and Allied Health Literature (Cinahl), PsycINFO, and the Turning Research Into Practice [TRIP] database).MethodA qualitative approach to reviewing the literature on recruitment and retention of GPs was used. The studies included were English-language studies from Organisation for Economic Cooperation and Development countries. The titles and abstracts of 138 articles were reviewed and analysed by the research team.ResultsSome of the most important determinants to increase recruitment in primary care were early exposure to primary care practice, the fit between skills and attributes, and a significant experience in a primary care setting. Factors that seemed to influence retention were subspecialisation and portfolio careers, and job satisfaction. The most important determinants of recruitment and retention were intrinsic and idiosyncratic factors, such as recognition, rather than extrinsic factors, such as income.ConclusionAlthough the published evidence relating to GP recruitment and retention is limited, and most focused on attracting GPs to rural areas, the authors found that there are clear overlaps between strategies to increase recruitment and retention. Indeed, the most influential factors are idiosyncratic and intrinsic to the individuals.

• 2

  The role of the Quality and Outcomes Framework in the care of long-term conditions: a systematic review

  The British journal of general practice : the journal of the Royal College of General Practitioners · 2017

  📚 106 citations🎯 RCR 5.43Top 7% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  BackgroundImproving care for people with long-term conditions is central to NHS policy. It has been suggested that the Quality and Outcomes Framework (QOF), a primary care pay-for-performance scheme that rewards practices for delivering effective interventions in long-term conditions, does not encourage high-quality care for this group of patients.AimTo examine the evidence that the QOF has improved quality of care for patients with long-term conditions.Design and settingThis was a systematic review of research on the effectiveness of the QOF in the UK.MethodThe authors searched electronic databases for peer-reviewed empirical quantitative research studying the effect of the QOF on a broad range of processes and outcomes of care, including coordination and integration of care, holistic and personalised care, self-care, patient experience, physiological and biochemical outcomes, health service utilisation, and mortality. Because the studies were heterogeneous, a narrative synthesis was carried out.ResultsThe authors identified three systematic reviews and five primary research studies that met the inclusion criteria. The QOF was associated with a modest slowing of both the increase in emergency admissions and the increase in consultations in severe mental illness (SMI), and modest improvements in diabetes care. The nature of the evidence means that the authors cannot be sure that any of these associations is causal. No clear effect on mortality was found. The authors found no evidence that the QOF influences integration or coordination of care, holistic care, self-care, or patient experience.ConclusionThe NHS should consider more broadly what constitutes high-quality primary care for people with long-term conditions, and consider other ways of motivating primary care to deliver it.

• 3

  Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages

  The American journal of sports medicine · 2010

  📚 61 citations🎯 RCR 1.99

  Lire l'abstract Crossref ↓

  Background: Microfracture and drilling elicit a cartilage repair whose quality depends on subchondral bone repair. Alternatively activated (AA) macrophages express arginase-1, release angiogenic factors, and could be potential mediators of trabecular bone repair. Hypothesis: Chitosan–glycerol phosphate (GP)/blood implants elicit arginase-1+ macrophages in vivo through neutrophil-dependent mechanisms and improve trabecular bone repair of drilled defects compared with drilling alone. Study Design: Controlled laboratory study. Methods: Bilateral trochlear cartilage defects were created in 15 rabbits, microdrilled, and treated or not with chitosan-GP/blood implant to analyze AA macrophages, CD-31+ blood vessels, bone, and cartilage repair after 1, 2, or 8 weeks. Neutrophil and macrophage chemotaxis to rabbit subcutaneous implants of autologous blood and chitosan-GP (±blood) was quantified at 1 or 7 days. In vitro, sera from human chitosan-GP/blood and whole blood clots cultured at 37°C were analyzed by proteomics and neutrophil chemotaxis assays. Results: Chitosan-GP/blood clots and whole blood clots released a similar profile of chemotactic factors (PDGF-BB, IL-8/CXCL8, MCP-1/CCL2, and no IL-1β or IL-6), although chitosan clot sera attracted more neutrophils in vitro. Subcutaneous chitosan-GP (±blood) implants attracted more neutrophils ( P < .001) and AA macrophages than whole blood clots in vivo. In repairing subchondral drill holes, chitosan-GP/blood implant attracted more AA macrophages at 1 and 2 weeks and more blood vessels at 2 weeks compared with drilled controls. Treatment elicited a more complete woven bone repair at 8 weeks than controls ( P = .0011) with a more uniform, integrated collagen type II+ cartilage repair tissue. Conclusion and Clinical Relevance: AA macrophages may play a role in the regeneration of subchondral bone, and chitosan-GP can attract and transiently accumulate these cells in the repair tissue. The resulting improved subchondral repair could be advantageous toward enhancing integration of a restored chondral surface to the subchondral bone.

Publications scientifiques (13) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• What are the impacts of setting up new medical schools? A narrative review

  Collection2022figshare

  Abstract Background The growth of the UK’s population together with an aging society with increasingly complex health and social care needs has placed a greater demand on statutory care services. In view of this emerging

• What are the impacts of setting up new medical schools? A narrative review

  Collection2022figshare

  Abstract Background The growth of the UK’s population together with an aging society with increasingly complex health and social care needs has placed a greater demand on statutory care services. In view of this emerging

• Rôle de la MSK1 dans la signalisation intracellulaire menant à la synthèse endothéliale de PAF induite par le VEGF

  Dissertation2005Université de Montréal

  Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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