Docteur ADRIANA MAGIRESCU

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• CH ARRONDISSEMENT DE MONTREUIL

  140 Chemin DEPARTEMENTAL 191, 62180 Rang-du-Fliers

  ☎ 0321894545Hospitalier🏥 Centre CH ↗🏥 Voir cet établissement
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• Des médecins du CHAM consultent à Étaples, les habitants n’ont plus à se déplacer - La Voix du Nord

  📰 La Voix du Nord · 30/11/2023

  <a href="https://news.google.com/rss/articles/CBMiywFBVV95cUxQbVRJd1Q3UXlTbWwwTFhWV3h3VjhWcjBRMGhnaGxjYmRFMndLTnBEMFpRbTNrblRYRmNqbElLQ2RSMkVPMXFKX0hLQzZ5NzNnMFJBekNwbFY1ci1mRUI1bERsVUxQeVlJVmxiMHFNSndJRzE1ZkQ0ZjNDVmtIX2J4dlRqQU9FRG9uS0VDd1pmMTFsdGJ5MmdoRnYtWHo1TVBLVl96WjRRdEVJQkxwT25UUjRkZ3RMaF83MH

Top publications · les plus citées

• 1

  Role and Therapeutic Potential for Targeting Fibroblast Growth Factor 10/FGFR1 in Relapsed Rheumatoid Arthritis

  Arthritis & rheumatology (Hoboken, N.J.) · 2024

  📚 31 citations🎯 RCR 5.26Top 7% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  ObjectiveFibroblast‐like synoviocytes (FLSs) contribute to inflammation and joint damage in rheumatoid arthritis (RA). However, the regulatory mechanisms of FLSs in relapse and remission of RA remain unknown. Identifying FLS heterogeneity and their underlying pathogenic roles may lead to discovering novel disease‐modifying antirheumatic drugs.MethodsCombining single‐cell RNA sequencing (scRNA‐seq) and spatial transcriptomics, we sequenced six matched synovial tissue samples from three patients with relapse RA and three patients in remission. We analyzed the differences in the transcriptomes of the FLS subsets between the relapse and remitted phases. We validated several key signaling pathways using quantitative real‐time PCR (qPCR) and multiplex immunohistochemistry (mIHC). We further targeted the critical signals in vitro and in vivo using the collagen‐induced arthritis (CIA) model in rats.ResultsLining and sublining FLS subsets were identified using scRNA‐seq. Differential analyses indicated that the fibroblast growth factor (FGF) pathway was highly activated in the lining FLSs from patients with relapse RA for which mIHC confirmed the increased expression of FGF10. Although the type I interferon pathway was also activated in the lining FLSs, in vitro stimulation experiment suggested that it was independent of the FGF10 pathway. FGF10 knockdown by small interfering RNA in FLSs significantly reduced the expression of receptor activator of NF‐κB ligand. Moreover, recombinant FGF10 protein enhanced bone erosion in the primary human‐derived pannus cell culture, whereas the FGF receptor (FGFR) 1 inhibitor attenuated this process. Finally, administering an FGFR1 inhibitor displayed a therapeutic effect in a CIA rat model.ConclusionThe FGF pathway is a critical signaling pathway in relapse RA. Targeted tissue‐specific inhibition of FGF10/FGFR1 may provide new opportunities to treat patients with relapse RA.

• 2

  The Effectiveness of Tuina in Relieving Pain, Negative Emotions, and Disability in Knee Osteoarthritis: A Randomized Controlled Trial

  Pain medicine (Malden, Mass.) · 2023

  📚 30 citations🎯 RCR 6.74Top 5% NIH🩺 Clinique

  Lire l'abstract Crossref ↓

  AbstractObjectiveTo evaluate the effectiveness of Tuina in relieving the pain, negative emotions, and disability of patients with knee osteoarthritis (KOA).DesignSingle-center, parallel, randomized controlled trial.SettingShanghai Guanghua Integrated Chinese and Western Medicine Hospital, Shanghai, China.SubjectsAdult patients with KOA who were able to speak Chinese and self-report symptoms were eligible.MethodsA total of 104 patients were randomly allocated to receive the 6-week treatment of Tuina (Tuina group) or celecoxib (celecoxib group). Data on pain, negative emotions, and disability were collected at baseline, at week 2, 4, and 6, and follow-up (1 month after the last treatment). The primary outcomes were the pressure pain thresholds. The secondary outcomes were: (1) numerical rating scale at rest and with movement; (2) Hamilton Anxiety Scale; (3) Hamilton Depression Scale; (4) Western Ontario and McMaster Universities Osteoarthritis Index; and (5) clinical effective rate. The adverse events of the trial were evaluated.ResultsIn total, 99 patients completed the follow-up. Generalized linear mixed models were constructed to analyse the between-group differences. Statistically significant differences were found in the interaction effects (P &amp;lt; .05). In evaluating the group effect, statistical differences were found at week 6 and follow-up (P &amp;lt; .05). Further, all variables showed a time effect (P &amp;lt; .05). A statistical difference in the clinical effective rate was found between the Tuina and celecoxib groups (P &amp;lt; .05).ConclusionsTuina produced superior effects for pain, negative emotions, and disability over time, as compared to celecoxib in patients with KOA.

• 3

  Gut microbiota alterations in critically ill older patients: a multicenter study

  BMC geriatrics · 2022

  📚 28 citations🎯 RCR 2.68Top 19% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract Background Aging generates changes in the gut microbiota, affecting its functionality. Little is known about gut microbiota in critically ill older adults. The objective of this study was to describe the profile of gut microbiota in a cohort of critically ill older adults. Methods This observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients over 18 years old who were admitted to the intensive care unit were enrolled. Fecal microbiota profiles were determined from 155 individuals, over 60 years old (n = 72) and under 60 years old (n = 83). Gut microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene. Alpha and beta diversity, operational taxonomic units and the interaction of gut microbiota with variables under study were analyzed. Amplicon sequence variants (ASVs) specifically associated with age were recovered by including gender, discharge condition, BMI, ICU stay and antibiotics as covariates in a linear mixed model. Results In older adults, sepsis, malnutrition, antibiotic prescription and severity (APACHE and SOFA scores) were higher than in the group under 60 years of age. Alpha diversity showed lower gut microbiota diversity in those over 60 years of age (p &lt; 0.05); beta diversity evidenced significant differences between the groups (PERMANOVA = 1.19, p = 0.038). The microbiota of the adults under 60 years old showed greater abundance of Murdochiella, Megasphaera, Peptoniphilus and Ezakiella, whereas those over 60 years old Escherichia-Shigella and Hungatella were more abundant. Conclusion The gut microbial community was altered by different factors; however, age significantly explained the variability in critically ill patients. A lower presence of beneficial genera and a higher abundance of pathogens was observed in adults over 60 years old.

Publications scientifiques (50) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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