M. Docteur LAURENT LACOSTE

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• CABINET DU DR LAURENT LACOSTE

  1TER RUE PIERRE TOUFAIRE, 17300 Rochefort

  ☎ 0546992240Libéral
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Top publications · les plus citées

• 1

  Renal tubular dysgenesis, a not uncommon autosomal recessive disorder leading to oligohydramnios: Role of the Renin-Angiotensin system

  Journal of the American Society of Nephrology : JASN · 2006

  📚 66 citations🎯 RCR 1.74
• 2

  Emergence of homochirality in large molecular systems

  Proceedings of the National Academy of Sciences of the United States of America · 2021

  📚 27 citations🎯 RCR 1.96🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Significance The selection of a single molecular handedness among the two possible configurations of a given molecule, or homochirality, is observed across all living matter and is a mystery in the origin of life. Here, we show that large chemical systems are likely to undergo a spontaneous symmetry breaking toward a homochiral state as the number of chiral species increases. Through an analysis of a large chemical database, we find that there is no need of very large molecules for chiral species to dominate over achiral ones; it already happens when molecules contain about 10 heavy atoms.

• 3

  Active urea transport independent of H+ and Na+ transport in frog skin epithelium

  The American journal of physiology · 1991

  📚 18 citations

  Lire l'abstract Crossref ↓

  We investigated the relationship between H+ secretion (JH), Na+ absorption (JNa), and urea transport (Ju) in skin of frogs (Rana esculenta) adapted to running tap water, NaCl (100 mM), and KCl (100 mM). In addition, cell morphological changes, particularly in the mitochondria-rich cells (MRC), were followed. NaCl adaptation stimulated an active Ju, reduced JNa and JH, and caused a decrease in the apical surface of MRC. After KCl adaptation, JNa and JH were increased and highly correlated, with a twofold increase in Ju, whereas the numerous MRC developed infoldings on their apical membranes. No correlation was found between JH and Ju. Clamping the skins in a range of +/- 50 mV or changing the external pH from 7.4 to 5.4 (at high cellular buffering power) had no effect on Ju. Depolarization of the basolateral membranes (serosal KCl-Ringer) had no effect on Ju. Ju was reversibly blocked by acidification of the cells by oxygen-free solution and sulfhydryl reagents (Hg2+, p-chloromercuribenzenesulfonic acid, and N-ethylmaleimide). Diethylstilbestrol, a proton transport blocker, had no effect on Ju. Apical addition of amiloride and derivatives (phenamil and ethylisopropyl amiloride) reversibly blocked Ju, whereas ouabain had no effect. We conclude that a cation (Na+ or H+)-dependent process is unlikely to exist in R. esculenta skin. A primary active transport in a two-step process is the simplest hypothesis to account for the energy-dependent Ju that develops in NaCl-adapted frogs.

Publications scientifiques (7) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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