Docteur ROGER GUILLEMINOT-LARUELLE
Diplômes
🎓 DES & spécialité ordinale
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Lieu de consultation
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Anti-cathepsin D immunotherapy triggers both innate and adaptive anti-tumour immunity in breast cancer
British journal of pharmacology · 2026
Lire l'abstract Crossref ↓
Abstract Background and Purpose Triple‐negative breast cancer (TNBC) has poorer outcomes than other breast cancers (BC), including HER2 + BC. Cathepsin D (CathD) is a poor prognosis marker overproduced by BC cells, hypersecreted in the tumour microenvironment with tumour‐promoting activity. Here, we characterized the immunomodulatory activity of the anti‐CathD antibody F1 and its improved Fab‐aglycosylated version (F1M1) in immunocompetent mouse models of TNBC (C57BL/6 mice harbouring E0771 cell grafts) and HER2‐amplified BC (BALB/c mice harbouring TUBO cell grafts). Experimental Approach CathD expression was evaluated by western blotting and immunofluorescence, and antibody binding to CathD by ELISA. Antibody anti‐tumour efficacy was investigated in mouse models. Immune cell recruitment and activation were assessed by immunohistochemistry, immunophenotyping, and RT‐qPCR. Key Results F1 and F1M1 antibodies remodelled the tumour immune landscape. Both antibodies promoted innate antitumour immunity by preventing the recruitment of immunosuppressive M2‐polarized tumour‐associated macrophages (TAMs) and by activating natural killer cells in the tumour microenvironment of both models. This translated into a reduction of T‐cell exhaustion markers in the tumour microenvironment that could be locally supported by enhanced activation of anti‐tumour antigen‐presenting cell (M1‐polarized TAMs and cDC1 cells) functions. Both antibodies inhibited tumour growth in the highly‐immunogenic E0771 model, but only marginally in the immune‐excluded TUBO model, indicating that anti‐CathD immunotherapy is more relevant for BC with a high immune cell infiltrate, as often observed in TNBC. Conclusion and implication Anti‐CathD antibody‐based therapy triggers the anti‐tumour innate and adaptive immunity in preclinical models of BC and is a promising immunotherapy for immunogenic TNBC. LINKED ARTICLES This article is part of a themed issue Immunotherapy in Cancer. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v183.6/issuetoc
- 2ESKD, Major Cardiovascular Events, and Death Associated With Systemic Inflammation
Kidney international reports · 2026
📚 1 citations🔓 Open Access - 3Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection
Immunity · 2026
📚 1 citations🔓 Open Access
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal33
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Transversal33
▼- Differential modulation of the sGC-cGMP pathway by sGC stimulators and activators in human lung cells
Biochemical pharmacology · 2026 · Journal Article
Montero P, Bayarri MA, Roger I, Escrivá J, et al.
- ASO Visual Abstract: Comparative Analysis of PIPAC Nozzle Designs: Ex Vivo Evaluation of Aerosol Distribution, Penetration and Tissue Concentration
Annals of surgical oncology · 2026 · Journal Article
Karam E, Kockelmann F, Romdhane V, Barbey S, et al.
- Distinct plasma proteome in severe pulmonary hypertension associated with chronic lung disease
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026 · Journal Article
Bosacoma A, Garcia AR, Lozano JJ, Sidorova J, et al.
- Comparative Analysis of PIPAC Nozzle Designs: Ex Vivo Evaluation of Aerosol Distribution, Penetration, and Tissue Concentration
Annals of surgical oncology · 2026 · Journal Article
Karam E, Kockelmann F, Romdhane V, Barbey S, et al.
- Prognostic value of PREVENT, PCE, and social determinants of health for cardiovascular mortality in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study
BMC public health · 2026 · Journal Article
Downie CG, Joo J, Hashemian M, Zhu F, et al.
- Al-MOF CAU-10 for Sorption-Enhanced CO(2)-to-Methanol Reaction: Role of the Hydrophilic/Hydrophobic Balance
ACS applied materials & interfaces · 2026 · Journal Article
Duplessis-Kergomard J, Bihl F, Rey D, Paris M, et al.
- Nociceptor neurons shape antiviral immunity
Journal of neuroinflammation · 2026 · Journal Article
Thomas I, Roger A, Rafei M, Gee K, et al.
- Biallelic variants in CHCHD4 are associated with combined OXPHOS defect leading to mitochondrial disease
HGG advances · 2026 · Journal Article
Mantecon M, Chhuon C, Roger K, Guerrera IC, et al.
- A finely annotated dataset for the automated acoustic identification of European Orthoptera and Cicadidae
Scientific data · 2026 · Journal Article
Funosas D, Massol E, Bas Y, Schmidt S, et al.
- Small cavitand macrocycles from direct C-C coupling of s-aryl tetrazine units
Chemical communications (Cambridge, England) · 2026 · Journal Article
Mboyi CD, Sabbadin H, Penouilh MJ, Bonnin Q, et al.
- Use of Paracervical Blocks for Patients Who Undergo Intrauterine Device Insertion
JAMA network open · 2026 · Journal Article
Roger JM, Costello J, Young H, Malave-Mendez TI, et al.
- Understanding the Impact of Hypoxia on Pulmonary Artery Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension Patients
International journal of molecular sciences · 2026 · Journal Article
Roger Y, Sardiné-Rama A, Bosacoma A, Gómez I, et al.
- ESKD, Major Cardiovascular Events, and Death Associated With Systemic Inflammation
Kidney international reports · 2026 · Journal Article
Halimi JM, Maisons V, de Fréminville JB, Roger S, et al.
📚 1 cit. - Insights into the role of the mechanosensitive Piezo1 channel and signaling mechanisms in CNS functions and diseases
Neuroscience and biobehavioral reviews · 2026 · Journal Article
Zhang M, Ge Y, Wang Z, Li H, et al.
- Evaluating the semi-chronic effects of household air pollution exposure on cardiopulmonary health under two different ventilation conditions
Scientific reports · 2026 · Journal Article
Aristizabal S, Snyder EM, Pope ZC, Senerat AM, et al.
- Targeting the Keap1-Nrf2 Axis in COPD: Comparative analysis of electrophilic and peptide-based Nrf2 activators in airway and immune cells
European journal of pharmacology · 2026 · Journal Article
Roger I, Estornut C, Montero P, Aparici M, et al.
- Nociceptor neurons control pollution-mediated neutrophilic asthma
eLife · 2026 · Journal Article
Wang JC, Kulle A, Crosson T, Reza Nikpoor A, et al.
- An estrogen receptor/E2F1/CDKN3 axis protects from UV-induced skin cancers in females
EMBO reports · 2026 · Journal Article
Lukowicz C, Winkler C, Roger C, Fowler JC, et al.
- Evaluating the efficacy of smoke management technologies in laparoscopic sleeve gastrectomy: insights from a prospective, single-centre comparative study
Scientific reports · 2026 · Journal Article
Demtröder CRD, Göhler D, Oelschlägel K, Jahn-Wolf C, et al.
- From Hearing Patterns to Functional Outcomes: Quantifying Audiometric Profiles for Precision Hearing Care
Audiology & neuro-otology · 2026 · Journal Article
Morvan P, Campi M, Staerman G, Roger P, et al.
- The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxia
Cell communication and signaling : CCS · 2026 · Journal Article
Duret T, Elmallah M, Heraud-Meley A, Tessier C, et al.
- Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection
Immunity · 2026 · Journal Article
Roger A, Fohrer T, Mardelle U, Thomas I, et al.
📚 1 cit. - Revisiting subclavian access in the ultrasound era: are we comparing sites or techniques? Author's reply
Critical care (London, England) · 2026 · Letter
Boulet N, Gavoille A, Roger C, Parienti JJ, et al.
- Multimorbidity in Atrial Fibrillation: Impact on Outcomes
Journal of the American Heart Association · 2026 · Journal Article
Manemann SM, Alonso A, Noseworthy PA, Siontis KC, et al.
- Assessing the Potential of the MTG-FCI Geostationary Mission for the Detection of Methane Plumes
Environmental science & technology · 2026 · Journal Article
Zhou S, Gorroño J, Roger J, Irakulis-Loitxate I, et al.
- Association of Area Deprivation Index in Kidney Cancer Mortality
Urology practice · 2026 · Journal Article
Viganò S, Tylecki A, Bertini A, Finocchiaro A, et al.
- Determinants of virological outcomes in kidney transplant recipients treated with maribavir for refractory cytomegalovirus infection
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026 · Journal Article
Kasriel N, Alain S, Benotmane I, Kamar N, et al.
📚 1 cit. - Anti-cathepsin D immunotherapy triggers both innate and adaptive anti-tumour immunity in breast cancer
British journal of pharmacology · 2026 · Journal Article
David T, Mallavialle A, Faget J, Alcaraz LB, et al.
📚 12 cit.🎯 RCR 12.00 - Strain-specific variation in virulence and host-immune modulation across the Cryptococcus gattii species complex
International journal of medical microbiology : IJMM · 2026 · Journal Article
Bellet V, Brochon L, Chable de la Héronnière F, Krasteva D, et al.
- Advancing reef recovery through insights into coral nutrition
iScience · 2026 · Journal Article
Matthews JL, Ferrier-Pagès C, Moorhead J, Peixoto RS, et al.
- Leveraging health records to identify diagnoses associated with recurrent pregnancy loss across two medical centers
iScience · 2026 · Journal Article
Roger J, Xie F, Costello JM, Tang AS, et al.
- Functionalization of Silicon Surfaces Using SI-ATRP and Click Chemistry for Anchoring Asymmetric Catalysts
Langmuir : the ACS journal of surfaces and colloids · 2026 · Journal Article
Bechara R, Roger P, Barroca-Aubry N, Aureau D, et al.
- Impaired thymic function is independently associated with an increased risk of posttransplant infections in kidney recipients
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026 · Journal Article
Aubert O, Kergaravat C, Katerinis I, Boudhabhay I, et al.
Case report / série3
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Case report / série3
▼- Peritonitis due to Gardnerella vaginalis in a male patient undergoing peritoneal dialysis: A case report
Nephrologie & therapeutique · 2026 · Journal Article
Mourre E, Berrada Y, Roger T, Lamy T, et al.
- Flow-Controlled Ventilation in Laparoscopic Surgery: A Case Series
A&A practice · 2026 · Journal Article
Ballout G, Roger M, Bergé R, Risco R, et al.
- Antipsychotics switching, a specific risk of thromboembolic events? A case report
Therapie · 2026 · Letter
Roger A, Sablé C, Bidouze L, Piquet V, et al.
Essai clinique3
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Essai clinique3
▼- Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU)
BMJ open · 2026 · Journal Article
Dépret F, Chousterman B, Roger C, Garnier M, et al.
🩺 Clinique - Mental Imagery to Enhance Procedural Skills in Peripheral Venous Catheterization: A Randomized Simulation Study in Medical Students
Perspectives on medical education · 2026 · Journal Article
Boulet N, Nairv H, Mezzarobba M, Saadi L, et al.
🩺 Clinique - Temporal Evaluation of the Metabolic Vulnerability Index and Its Components in a Heart Failure Clinical Trial Population
The journal of applied laboratory medicine · 2026 · Journal Article
Rafi R, Downie CG, Kuku KO, Remaley AT, et al.
Épidémiologie & registres2
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Épidémiologie & registres2
▼- Risk factors for enterococcal bacteraemia in urology: a multicentre cohort study
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026 · Journal Article
Roger PM, Ferre A, Abram B, Normand G, et al.
- Prevalence and associated risk factors of Mycoplasma genitalium infection in women in Western Cameroon: A cross sectional study
Indian journal of dermatology, venereology and leprology · 2026 · Journal Article
Sethi S, Boris GDE, Sharma N, Kanaujia R, et al.
Pharmacovigilance2
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Pharmacovigilance2
▼- Tissue differences and changes in the resident bacteriome composition of the Pacific oyster Magallana gigas in relation to trace metal contamination
Ecotoxicology and environmental safety · 2026 · Journal Article
Roger M, Le Monier P, Bruzac S, Noël C, et al.
- Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026 · Journal Article
Massonnaud CR, Peiffer-Smadja N, Poignard P, Jamard S, et al.
🩺 Clinique
Gériatrie1
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Gériatrie1
▼- Heart failure in the elderly: epidemiology, mechanisms, and management
European heart journal · 2026 · Journal Article
de Boer RA, Abdellatif M, Bauersachs J, Roger VL
IA en rhumatologie1
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IA en rhumatologie1
▼- A deep learning approach to assess transendothelial cell trafficking performance
Scientific reports · 2026 · Journal Article
Schumacher TM, Gottloeber EM, Koziel E, Sacma M, et al.
Qualité de vie / PROMs1
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Qualité de vie / PROMs1
▼- Longitudinal Assessment of Health-Related Quality of Life in Adults with CKD
Kidney360 · 2026 · Journal Article
Ng O, Teixeira-Pinto A, Kieu A, van Zwieten A, et al.
Revue générale1
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Revue générale1
▼- Longitudinally Extensive Transverse Myelitis in Autoimmune Connective Tissue Diseases: A Comprehensive Review
Cureus · 2026 · Journal Article
R GS, K N
Risque cardio-vasculaire1
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Risque cardio-vasculaire1
▼- Prognostic value of jugular, pulmonary and inferior vena cava ultrasound in decompensated heart failure in primary care
International journal of cardiology. Cardiovascular risk and prevention · 2026 · Journal Article
Cendrós V, Navas E, Miranzo E, Muñoz MÁ, et al.
Santé mentale / fatigue1
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Santé mentale / fatigue1
▼- The therapeutic potential of compounds from natural products for alleviating depression by targeting P2X7 receptor-mediated proinflammatory signaling pathways
Frontiers in immunology · 2026 · Journal Article
Bai XY, Wang GL, Zhang Y, Cheng Q, et al.
Vascularites des gros vaisseaux1
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Vascularites des gros vaisseaux1
▼- A Silent Vasculitis With a Loud Presentation: Takayasu Arteritis Causing Intracerebral Hemorrhage
Cureus · 2026 · Case Reports
R S, Nanda M S, Adalarasan S, Subramanian Y, et al.