Mme Docteur Elsa DENOIX

Bibliographie

• Unexpected diagnosis of COVID-19-associated disorders by SARS-CoV-2-specific serology

  2020

  ArticleJournal of Clinical Virology

• Primary Hyperparathyroidism in Sickle Cell Disease: An Unknown Complication of the Disease in Adulthood

  2020

  ArticleJournal of Clinical Medicine

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

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• CABINET DU DR Elsa DENOIX

  CLINIQUE TRENEL — 575 RUE DU DOCTEUR TRENEL, 69560 Sainte-Colombe

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Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  What are the predictors of clinical success after percutaneous vertebroplasty for osteoporotic vertebral fractures?

  European radiology · 2018

  📚 12 citations🎯 RCR 1.13
• 2

  Unexpected diagnosis of COVID-19-associated disorders by SARS-CoV-2-specific serology

  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020

  📚 7 citations🔓 Open Access📄 PDF gratuit ↗
• 3

  Primary Hyperparathyroidism in Sickle Cell Disease: An Unknown Complication of the Disease in Adulthood

  Journal of clinical medicine · 2020

  📚 6 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Primary hyperparathyroidism (pHPT) is the third most common endocrine disorder and usually affects patients between 60 and 70 years of age. To our knowledge, this condition has never been studied in young patients with sickle cell disease (SCD). Our objective was to describe the clinical and biological characteristics of pHPT in adult patients with SCD and its management. We conducted a retrospective study that included SCD patients who were diagnosed with pHPT in four SCD referral centers. pHPT was defined by the presence of elevated serum calcium levels with inappropriate normal or increased parathyroid hormone (PTH) serum levels or histopathological evidence of parathyroid adenoma or hyperplasia. Patients with severe renal impairment (GFR <30 mL/min) were excluded. Twenty-eight patients (18 women, 64%; 22 homozygous genotype, 79%) were included. The median age at pHPT diagnosis was 41 years (interquartile range –IQR- 31.5–49.5). The median serum calcium and PTH concentration were, respectively, 2.62 mmol/L (IQR 2.60–2.78) and 105 pg/mL (IQR 69–137). Bone mineral density (BMD) revealed very low BMD (≤−2.5 SD) in 44% of patients explored (vs. 12.5% among 32 SCD patients matched for SCD genotype, sex, age, and BMI, p = 0.03). Fourteen patients (50%) received surgical treatment, which was successful in all cases, but four of these patients (29%) presented with pHPT recurrence after a median time of 6.5 years. Three of these patients underwent a second cervical surgery that confirmed the presence of a new parathyroid adenoma. These results suggest that SCD is a condition associated with pHPT in young subjects. SCD patients with pHPT have a high risk of very low BMD. A diagnosis of pHPT should be suspected in the presence of mild hypercalcemia or low BMD in SCD patients.

Publications scientifiques (3) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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