Docteur DAVID PERARD

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• GCS MEDIPOLE LYON-VILLEURBANNE - SIEGE

  158 Rue LEON BLUM, 69100 Villeurbanne

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• CABINET DU DR DAVID PERARD

  GCS MEDIPOLE LYON-VILLEURBANNE — 158 RUE LEON BLUM, 69100 Villeurbanne

  Libéral

• CABINET DU DR DAVID PERARD

  CEABOS — 5BIS AVENUE ANTOINE DUTRIEVOZ, 69100 Villeurbanne

  Libéral

• CABINET DU DR DAVID PERARD

  CLINIQUE DU PARC — 155 BOULEVARD DE STALINGRAD, 69006 Lyon

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• CABINET DU DR DAVID PERARD

  46 AVENUE CONDORCET, 69100 Villeurbanne

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Clonal haematopoiesis of indeterminate potential and cardiovascular events in systemic lupus erythematosus (HEMATOPLUS study)

  Rheumatology (Oxford, England) · 2022

  📚 37 citations🎯 RCR 2.52Top 20% NIH🩺 Clinique🔓 Open Access

  Lire l'abstract Crossref ↓

  Abstract Objective The detection of somatic mutations among the genes of myeloid cells in asymptomatic patients—defining clonal haematopoiesis of indeterminate potential (CHIP)—is associated with a predisposition to cardiovascular events (CVEs) in the general population. We aimed to determine whether CHIP was associated with CVEs in SLE patients. Methods The study is an ancillary study of the randomized, double-blind, placebo-controlled, multicentre PLUS trial conducted from June 2007 through August 2010 at 37 centres in France, involving 573 SLE patients. The search for somatic mutations by high-throughput sequencing of 53 genes involved in clonal haematopoiesis was performed on genomic DNA collected at PLUS inclusion. CHIP prevalence was assessed in SLE and in a retrospective cohort of 479 patients free of haematological malignancy. The primary outcome was an incident CVE in SLE. Results Screening for CHIP was performed in 438 SLE patients [38 (29–47) years, 91.8% female]. Overall, 63 somatic mutations were identified in 47 patients, defining a CHIP prevalence of 10.7% in SLE. Most SLE patients (78.7%) carried a single mutation. Most variants (62.5%) were located in the DNMT3A gene. CHIP frequency was related to age and to age at SLE diagnosis, and was associated with a lower frequency of aPLs. CHIP occurred >20 years earlier (P < 0.00001) in SLE than in controls. The detection of CHIP at inclusion was not found to be associated with occurrence of CVEs during follow-up [HR = 0.42 (0.06–3.21), P = 0.406]. Conclusion The prevalence of CHIP is relatively high in SLE for a given age, but was not found to be associated with incident CVEs. Trial registration ClinicalTrials.gov, https://clinicaltrials.gov, NCT05146414.

• 2

  Soluble CD163 and incident cardiovascular events in patients with systemic lupus erythematosus: An observational cohort study

  Journal of internal medicine · 2022

  📚 4 citations🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (2) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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