Docteur Thibault DAUVERGNE

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• CABINET DU DR Thibault DAUVERGNE

  56 AVENUE DE BEAUGAILLARD, 37550 Saint-Avertin

  Libéral

• CHRU TROUSSEAU - CHAMBRAY

  Avenue DE LA REPUBLIQUE, 37170 Chambray-lès-Tours

  ☎ 0247474747Hospitalier🏥 Voir cet établissement

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study

  American journal of respiratory and critical care medicine · 2017

  📚 132 citations🎯 RCR 5.83Top 6% NIH🩺 Clinique

  Lire l'abstract Crossref ↓

  Abstract Rationale Sevoflurane improves gas exchange, and reduces alveolar edema and inflammation in preclinical studies of lung injury, but its therapeutic effects have never been investigated in acute respiratory distress syndrome (ARDS). Objectives To assess whether sevoflurane would improve gas exchange and inflammation in ARDS. Methods We did a parallel, open-label single-center randomized controlled trial at three intensive care units from a French university hospital between April 2014 and February 2016. Adult patients were randomized within 24 hours of moderate-to-severe ARDS onset to receive either intravenous midazolam or inhaled sevoflurane for 48 hours. The primary outcome was the PaO2/FiO2 ratio on Day 2. Secondary endpoints included alveolar and plasma levels of cytokines and soluble form of the receptor for advanced glycation end-products, and safety. Investigators who did the analyses were masked to group allocation. Analysis was by intention to treat. Measurements and Main Results Twenty-five patients were assigned to the sevoflurane group and 25 to the midazolam group. On Day 2, PaO2/FiO2 ratio was higher in the sevoflurane group than in the midazolam group (mean ± SD, 205 ± 56 vs. 166 ± 59, respectively; P = 0.04). There was a significant reduction over time in cytokines and soluble form of the receptor for advanced glycation end-products levels in the sevoflurane group, compared with the midazolam group, and no serious adverse event was observed with sevoflurane. Conclusions In patients with ARDS, use of inhaled sevoflurane improved oxygenation and decreased levels of a marker of epithelial injury and of some inflammatory markers, compared with midazolam. Clinical trial registered with www.clinicaltrials.gov (NCT 02166853).

• 2

  Fat-free mass at admission predicts 28-day mortality in intensive care unit patients: the international prospective observational study Phase Angle Project

  Intensive care medicine · 2016

  📚 106 citations🎯 RCR 5.47Top 7% NIH🩺 Clinique
• 3

  Molecular mechanisms underlying the enhanced analgesic effect of oxycodone compared to morphine in chemotherapy-induced neuropathic pain

  PloS one · 2014

  📚 40 citations🎯 RCR 1.75🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (4) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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