Docteur Léa CHAUVEAU

Thèses universitaires

• Neuroimagerie des altérations du lobe temporal médian : avancées pour la compréhension, l'évaluation et la prévention de la maladie d'Alzheimer 22017004

  2024

  Neuroimaging of medial temporal lobe alterations : advances in understanding, assessing, and preventing Alzheimer's disease

  Sciences de la vie et de la santé🎓 Normandie

  Direction : Robin de Flores, Gaël Chételat

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• EEG Brain Rhythms During Resting‐State Wakefulness and Sleep in Elderly Expert Meditators

  2025

  ArticleJournal of Sleep Research

• Effects of an 18-month meditation training on dynamic functional connectivity states in older-adults: Secondary analyses from the Age-Well randomized controlled trial

  2025

  ArticleImaging Neuroscience

• Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study

  2025

  ArticleFrontiers in Aging Neuroscience

• Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well

  2025

  ArticleBiological Psychiatry Global Open Science

• Depressive symptoms in older adults are associated with changes in stress-related markers, functional connectivity and brain volume

  2025

  ArticleAlzheimer's Research and Therapy

• Effect of an 18-Month Meditation Training on Telomeres in Older Adults: A Secondary Analysis of the Age-Well Randomized Controlled Trial

  2025

  ArticleBiological Psychiatry Global Open Science

• Decoding meditation mechanisms underlying brain preservation and psycho-affective health in older expert meditators and older meditation-naive participants

  2024

  ArticleScientific Reports

• Respective influence of beta-amyloid and APOE ε4 genotype on medial temporal lobe subregions in cognitively unimpaired older adults

  2023

  ArticleNeurobiology of Disease

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Medial Temporal Lobe Subregional Atrophy in Aging and Alzheimer's Disease: A Longitudinal Study

  Frontiers in aging neuroscience · 2021

  📚 53 citations🎯 RCR 4.20Top 10% NIH🔓 Open Access

  Lire l'abstract Crossref ↓

  Medial temporal lobe (MTL) atrophy is a key feature of Alzheimer's disease (AD), however, it also occurs in typical aging. To enhance the clinical utility of this biomarker, we need to better understand the differential effects of age and AD by encompassing the full AD-continuum from cognitively unimpaired (CU) to dementia, including all MTL subregions with up-to-date approaches and using longitudinal designs to assess atrophy more sensitively. Age-related trajectories were estimated using the best-fitted polynomials in 209 CU adults (aged 19–85). Changes related to AD were investigated among amyloid-negative (Aβ−) (n = 46) and amyloid-positive (Aβ+) (n = 14) CU, Aβ+ patients with mild cognitive impairment (MCI) (n = 33) and AD (n = 31). Nineteen MCI-to-AD converters were also compared with 34 non-converters. Relationships with cognitive functioning were evaluated in 63 Aβ+ MCI and AD patients. All participants were followed up to 47 months. MTL subregions, namely, the anterior and posterior hippocampus (aHPC/pHPC), entorhinal cortex (ERC), Brodmann areas (BA) 35 and 36 [as perirhinal cortex (PRC) substructures], and parahippocampal cortex (PHC), were segmented from a T1-weighted MRI using a new longitudinal pipeline (LASHiS). Statistical analyses were performed using mixed models. Adult lifespan models highlighted both linear (PRC, BA35, BA36, PHC) and nonlinear (HPC, aHPC, pHPC, ERC) trajectories. Group comparisons showed reduced baseline volumes and steeper volume declines over time for most of the MTL subregions in Aβ+ MCI and AD patients compared to Aβ− CU, but no differences between Aβ− and Aβ+ CU or between Aβ+ MCI and AD patients (except in ERC). Over time, MCI-to-AD converters exhibited a greater volume decline than non-converters in HPC, aHPC, and pHPC. Most of the MTL subregions were related to episodic memory performances but not to executive functioning or speed processing. Overall, these results emphasize the benefits of studying MTL subregions to distinguish age-related changes from AD. Interestingly, MTL subregions are unequally vulnerable to aging, and those displaying non-linear age-trajectories, while not damaged in preclinical AD (Aβ+ CU), were particularly affected from the prodromal stage (Aβ+ MCI). This volume decline in hippocampal substructures might also provide information regarding the conversion from MCI to AD-dementia. All together, these findings provide new insights into MTL alterations, which are crucial for AD-biomarkers definition.

• 2

  Anterior-temporal network hyperconnectivity is key to Alzheimer's disease: from ageing to dementia

  Brain : a journal of neurology · 2025

  📚 10 citations🎯 RCR 4.25🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract Curing Alzheimer's disease remains hampered by an incomplete understanding of its pathophysiology and progression. Exploring dysfunction in medial temporal lobe networks, particularly the anterior-temporal (AT) and posterior-medial (PM) systems, might provide key insights, because these networks exhibit alterations in functional connectivity along the entire Alzheimer's continuum, potentially influencing disease propagation. However, the specific changes in each network and their clinical relevance across stages are not yet fully understood. This requires consideration of commonly used biomarkers, clinical progression, individual variability and age confounds. Here, we leveraged monocentric longitudinal data from 261 participants spanning the adult lifespan and the Alzheimer's continuum. The sample included cognitively unimpaired adults aged 19–85 years (n = 209; 8 of 64 older adults >60 years of age were amyloid-β-positive) and amyloid-β-positive patients fulfilling diagnostic criteria for mild cognitive impairment (MCI, n = 26; 18 progressed to Alzheimer-dementia within 7 years) or Alzheimer's-type dementia (n = 26). Participants underwent structural and resting-state functional MRI, florbetapir and 18F-fluorodeoxyglucose-PET and global cognitive assessments, with up to three visits over a maximum period of 47 months. Network connectivity was assessed using seed-based analyses with the perirhinal and parahippocampal cortices as seeds, within data-driven masks reflecting the AT and PM networks. Generalized additive and linear mixed models were run to assess age-specific effects and Alzheimer's-related alterations. In this context, we explored various markers of pathological and clinical severity, including cerebral amyloid uptake, glucose metabolism, hippocampal volume, global cognition, diagnostic staging and time to dementia onset. Our findings revealed distinct patterns of connectivity linked to normal ageing or Alzheimer's disease. Advancing age throughout adulthood was associated with lower PM connectivity and more subtle changes in AT connectivity, and Alzheimer's disease was characterized by AT hyperconnectivity without global changes in PM connectivity. Specifically, AT connectivity was higher in MCI and Alzheimer-dementia patients compared with older controls and was positively associated with amyloid burden, glucose hypometabolism, hippocampal atrophy and global cognitive deficits in older adults, ranging from unimpaired to demented. Additionally, higher AT connectivity was correlated with faster progression to Alzheimer-dementia in MCI patients. This comprehensive approach allowed us to reveal that excessive connectivity within the AT network is linked intrinsically to the pathological and clinical progression of Alzheimer's disease. These insights might guide future research to a better understanding of cascading events leading to the disease and hold promise for developing prognostic tools and therapeutic interventions targeting these specific network alterations.

• 3

  Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study

  Frontiers in aging neuroscience · 2025

  📚 5 citations🎯 RCR 2.16🔓 Open Access

  Lire l'abstract Crossref ↓

  IntroductionAllostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer’s disease (AD) in a healthy elderly population and with a multimodal approach.MethodsAt baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.ResultsAL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.DiscussionAL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (β-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.

Publications scientifiques (11) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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