Mme Docteur ALINE CHARPENTIER

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Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieu de consultation

• CABINET DU DR ALINE CHARPENTIER

  9 AVENUE DU PARC, 90000 Belfort

  Libéral
  197 m197 m197 m197 m

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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• Belfort. Aline et Jérémy - L'Est Républicain

  📰 L'Est Républicain · 26/11/2017

  <a href="https://news.google.com/rss/articles/CBMimgFBVV95cUxPckw3d19KZkh0MkhTYmQyVlZ2X2xYYmx0WXlERnh0SXBBamhLUE15Yk91UF85UWR1OGpWZHN2LUhDU3NWSlNFRFBwM2w5N2xnVXlLTV92WjRxaDg2RFVFSHVVc0ZiSnV3VjNCSEx1Tm5oVDJkaGRCQnNfeVBxcVg3Q1BjZVUzY0hYRVhIRF9BclhxVVRUZzZZODR3?oc=5" target="_blank">Belfort. Aline et J

Top publications · les plus citées

• 1

  Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF

  Cell communication and signaling : CCS · 2023

  📚 43 citations🎯 RCR 5.90Top 6% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract Background Osteoarthritis is an age-related disease that currently faces a lack of symptomatic treatment. Inflammation, which is mainly sustained by pro-inflammatory cytokines such as IL-1b, TNF, and IL-6, plays an important role in osteoarthritis progression. In this context, pro-inflammatory cytokines are widely used to mimic the inflammatory component of osteoarthritis in vitro. However, the therapeutic failures of clinical trials evaluating anti-cytokines drugs highlight the lack of overall understanding of the effects of these cytokines on chondrocytes. Methods Here, we generated a comprehensive transcriptomic and proteomic dataset of osteoarthritic chondrocytes treated with these cytokines to describe their pro-inflammatory signature and compare it to the transcriptome of non-osteoarthritic chondrocytes. Then, the dysregulations highlighted at the molecular level were functionally confirmed by real-time cellular metabolic assays. Results We identified dysregulation of metabolic-related genes in osteoarthritic chondrocytes but not in non-osteoarthritic chondrocytes. A metabolic shift, toward increased glycolysis at the expense of mitochondrial respiration, was specifically confirmed in osteoarthritic chondrocytes treated with IL-1b or TNF. Conclusion These data show a strong and specific association between inflammation and metabolism in osteoarthritic chondrocytes, which was not found in non-osteoarthritic chondrocytes. This indicates that the link between inflammation and metabolic dysregulation may be exacerbated during chondrocyte damage in osteoarthritis.

• 2

  Biomarker variation in patients successfully treated with tocilizumab for severe coronavirus disease 2019 (COVID-19): results of a multidisciplinary collaboration

  Clinical and experimental rheumatology · 2020

  📚 25 citations🎯 RCR 1.17
• 3

  Predictive factors of mortality in patients treated with tocilizumab for acute respiratory distress syndrome related to coronavirus disease 2019 (COVID-19)

  Microbes and infection · 2020

  📚 13 citations🔓 Open Access

Publications scientifiques (5) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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