Docteur Francois CAPON

Thèses universitaires

• La synoviolyse laser co2 sous arthroscopie gazeuse : etude experimentale

  1990
  Médecine🎓 Lille 2

  Direction : Bernard Duquesnoy

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• A Diferrous Dithiolate as a Model of the Elusive H ox inact State of the [FeFe] Hydrogenases: An Electrochemical and Theoretical Dissection of Its Redox Chemistry

  2015

  ArticleInorganic Chemistry

• New Fe I -Fe I Complex Featuring a Rotated Conformation Related to the [2 Fe] H Subsite of [Fe-Fe] Hydrogenase

  2013

  ArticleChemistry - A European Journal

• Electrochemical and Theoretical Investigations of the Role of the Appended Base on the Reduction of Protons by [Fe 2 (CO) 4 (? 2 -PNP R )(?-S(CH 2 ) 3 S] (PNP R ={Ph 2 PCH 2 } 2 NR, R=Me, Ph)

  2012

  ArticleChemistry - A European Journal

• Electrochemical and Theoretical Studies of the Impact of the Chelating Ligand on the Reactivity of [Fe 2 (CO) 4 (? 2 -LL)(?-pdt)] + Complexes with Different Substrates (LL = I Me -CH 2 -I Me , dppe; I Me = 1-Methylimidazol-2-ylidene)

  2012

  ArticleOrganometallics

• Oxidatively Induced Reactivity of [Fe 2 (CO) 4 (κ 2 -dppe)(μ-pdt)]: an Electrochemical and Theoretical Study of the Structure Change and Ligand Binding Processes

  2011

  ArticleInorganic Chemistry

• Diiron Complexes with a [2Fe3S] Core Related to the Active Site of [FeFe]H2ases

  2011

  ArticleEuropean Journal of Inorganic Chemistry

• Diiron species containing a cyclic P Ph 2 N Ph 2 diphosphine related to the [FeFe]H 2 ases active site

  2011

  ArticleChemical Communications

• Tuning of electron transfer in diiron azo-bridged complexes relevant to hydrogenases

  2010

  ArticleInternational Journal of Hydrogen Energy

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Livres & ouvrages

• 📕

  LA SYNOVIOLYSE LASER CO2 SOUS ARTHROSCOPIE GAZEUSE

  ETUDE EXPERIMENTALE

  1990

Source : Google Books — filtre catégories médicales/santé/sciences.

Lieu de consultation

• CHU ANGERS SITE LARREY

  4 Rue LARREY, 49933 Angers

  ☎ 0241353637Hospitalier🏥 Centre CHU ↗🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Searching for psoriasis susceptibility genes in Italy: genome scan and evidence for a new locus on chromosome 1

  The Journal of investigative dermatology · 1999

  📚 135 citations🎯 RCR 2.98Top 16% NIH🔓 Open Access📄 PDF gratuit ↗
• 2

  Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

  eLife · 2017

  📚 57 citations🎯 RCR 2.00🔓 Open Access

  Lire l'abstract Crossref ↓

  Pharmacological targeting of transcription factors holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have yielded limited success to date. Transcription factors typically engage in complex interaction networks, likely masking the effects of specifically inhibiting single protein-protein interactions. Here, we used a combination of genomic, proteomic and biophysical methods to discover a suite of protein-protein interactions involving the SOX18 transcription factor, a known regulator of vascular development and disease. We describe a small-molecule that is able to disrupt a discrete subset of SOX18-dependent interactions. This compound selectively suppressed SOX18 transcriptional outputs in vitro and interfered with vascular development in zebrafish larvae. In a mouse pre-clinical model of breast cancer, treatment with this inhibitor significantly improved survival by reducing tumour vascular density and metastatic spread. Our studies validate an interactome-based molecular strategy to interfere with transcription factor activity, for the development of novel disease therapeutics.

• 3

  Small-Molecule Inhibitors of the SOX18 Transcription Factor

  Cell chemical biology · 2017

  📚 44 citations🎯 RCR 1.50🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (7) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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