Docteur DELPHINE BREGEON

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

• Synthesis of phosphoantigens: scalable accesses to enantiomers of BrHPP and studies on N-HDMAPP synthesis

  2012

  ArticleBioorganic and Medicinal Chemistry Letters

• Thiazolinium salt: an efficient catalyst for the Mukaiyama reaction

  2009

  ArticleTetrahedron Letters

• (S)-Histidine: the ideal precursor for a novel family of chiral aminoacid and peptidic ionic liquids

  2006

  ArticleTetrahedron Letters

• Chiral ionic liquids, a renewal for the chemistry of chiral solvents? Design, synthesis and applications for chiral recognition and asymmetric synthesis

  2005

  ArticleTetrahedron: Asymmetry

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

• CABINET DU DR DELPHINE BREGEON

  25 BOULEVARD GABRIEL GUIST HAU, 44000 Nantes

  ☎ 0240082000Libéral

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• La directrice du groupe scolaire Jean-Zay - Ouest-France

  📰 Ouest-France · 07/07/2018

  <a href="https://news.google.com/rss/articles/CBMirAFBVV95cUxQeUcyelMtd3o3LVBXM1BjWEpyR2JySE1ub2RNaU1YY3ppczUzWFZwOFlKZjN5Vm10cnRIWHJ6UVR2aDRuMHd1c0VOLWlJbHk0c1l1TFRSdWZQMVdaT1NxMzRhUnNna2lwb0taMWozLXEyRzBrOURMUmlsTU9nU2pxYXczdm5JMFIyNE9veklERG4tTU1kcGJzUmZwbTZFRWVOUnk3WDRxdm5zMmdD?oc=5" target="_bl

Top publications · les plus citées

• 1

  Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor control

  Open research Europe · 2021

  📚 8 citations🔓 Open Access

  Lire l'abstract Crossref ↓

  Background: MICA and MICB are tightly regulated stress-induced proteins that trigger the immune system by binding to the activating receptor NKG2D on cytotoxic lymphocytes. MICA and MICB are highly polymorphic molecules with prevalent expression on several types of solid tumors and limited expression in normal/healthy tissues, making them attractive targets for therapeutic intervention. Methods: We have generated a series of anti-MICA and MICB cross-reactive antibodies with the unique feature of binding to the most prevalent isoforms of both these molecules. Results: The anti-MICA and MICB antibody MICAB1, a human IgG1 Fc-engineered monoclonal antibody (mAb), displayed potent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) of MICA/B-expressing tumor cells in vitro . However, it showed insufficient efficiency against solid tumors in vivo , which prompted the development of antibody-drug conjugates (ADC). Indeed, optimal tumor control was achieved with MICAB1-ADC format in several solid tumor models, including patient-derived xenografts (PDX) and carcinogen-induced tumors in immunocompetent MICAgen transgenic mice. Conclusions: These data indicate that MICA and MICB are promising targets for cytotoxic immunotherapy.

• 2

  Synthesis of phosphoantigens: scalable accesses to enantiomers of BrHPP and studies on N-HDMAPP synthesis

  Bioorganic & medicinal chemistry letters · 2012

  📚 3 citations

Publications scientifiques (2) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Partager cette fiche