Docteur ALICE TISON
✨ Profil synthétique
IA · 05/05/2026Le Docteur Alice Tison est une rhumatologue hospitalière à Brest, avec une production scientifique significative dans le domaine de la rhumatologie. Ses recherches portent notamment sur les thérapies et les biomarqueurs du cancer, les troubles des glandes salivaires, ainsi que le traitement et les études sur l'arthrite rhumatoïde. Avec un h-index de 11 et 56 publications, elle démontre une activité de recherche régulière.
Expertises présumées
- Sjögren
- Biothérapies non-anti-TNF
- Corticothérapie
- JAK inhibiteurs
- Épidémiologie des maladies rhumatismales
- Vasculite
- Arthrite rhumatoïde
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
11
h articles cités ≥ h fois chacun. Un h de 11 = 11 publications avec 11+ citations.
Citations
1 133
Publications
56
i10-index
11
Thématiques principales
- Cancer Immunotherapy and Biomarkers ×18
- Salivary Gland Disorders and Functions ×8
- Rheumatoid Arthritis Research and Therapies ×7
- Colorectal Cancer Treatments and Studies ×7
- Vasculitis and related conditions ×6
Affiliations FR : Inserm · Université de Bretagne Occidentale · Centre Hospitalier Régional Universitaire de Brest
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
Practical management of rheumatic immune-related adverse events occurring with immune checkpoint inhibitors: A narrative review
2026ArticleJoint Bone Spine
Usefulness of 18F-FDG PET-CT in detecting subclinical arteritis and cancer associated with polymyalgia rheumatica
2026ArticleJoint Bone Spine
Baricitinib in early polymyalgia rheumatica (BACHELOR): a randomised, double-blind, placebo-controlled, parallel-group trial
2025ArticleThe Lancet Rheumatology
Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease
2025ArticleRheumatology and Therapy
Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study
2024ArticleRheumatology
Immune Checkpoint Inhibitor-induced Polymyalgia Rheumatica
2024ArticleRheumatic Disease Clinics of North America
Detection of hypophosphatasia in hospitalised adults in rheumatology and internal medicine departments: a multicentre study over 10 years
2024ArticleRMD Open : Rheumatic & Musculoskeletal Diseases
Association of Combined Anti‐Ro52 / TRIM21 and Anti‐Ro60 / SSA Antibodies With Increased Sjögren Disease Severity Through Interferon Pathway Activation
2024ArticleArthritis & rheumatology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Lieu de consultation
CHRU BREST SITE HOPITAL CAVALE BLANCHE
Boulevard TANGUY PRIGENT, 29609 Brest
☎ 0298223333Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Articles de presse (1)
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
- Jeunes chercheurs. Les trois lauréats 2018 - Le Télégramme
📰 Le Télégramme · 28/04/2018
<a href="https://news.google.com/rss/articles/CBMisAFBVV95cUxQZzNPbnNuR0c2bW5iM3c1TjVXbXRxYzRVQzdkWDBpbGx6NGpNelMwWEhhbGJaYWRBS2dUS1RxUGpycFpSak5FWk1laGh2eWdwY213a3pIU01hdnhoaTJDRzNPd1prR1hRaE5kdDVmTTlmU2NpX3Y3eFRBdVVZNjJaQ0o5ZndzSVk4MWExS3ZGbDRIU2FBdnZHTTdyNUJ1RTVNaGxSZUN1NWIzVEZfaFFzMg?oc=5" targe
Top publications · les plus citées
- 1Safety and Efficacy of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease: A Nationwide, Multicenter Cohort Study
Arthritis & rheumatology (Hoboken, N.J.) · 2019
Lire l'abstract Crossref ↓
ObjectiveImmune checkpoint inhibitors (ICIs) for cancer therapy frequently induce immune‐related adverse effects (IRAEs). Therefore, most patients with preexisting autoimmune diseases have been excluded from clinical trials of ICIs. This study was undertaken to evaluate the safety and efficacy of ICIs in patients with preexisting autoimmune disease and cancer.MethodsA retrospective cohort study was conducted from January 2017 to January 2018 via 3 French national networks of experts in oncology and autoimmunity. Adults with preexisting autoimmune disease who were receiving ICIs were assessed for the occurrence of flare of preexisting autoimmune disease, other IRAEs, and cancer response.ResultsThe study included 112 patients who were followed up for a median of 8 months. The most frequent preexisting autoimmune diseases were psoriasis (n = 31), rheumatoid arthritis (n = 20), and inflammatory bowel disease (n = 14). Twenty‐four patients (22%) were receiving immunosuppressive therapy at ICI initiation. Autoimmune disease flare and/or other IRAE(s) occurred in 79 patients (71%), including flare of preexisting autoimmune disease in 53 patients (47%) and/or other IRAE(s) in 47 patients (42%), with a need for immunosuppressive therapy in 48 patients (43%) and permanent discontinuation of ICI in 24 patients (21%). The median progression‐free survival was shorter in patients receiving immunosuppressive therapy at ICI initiation (3.8 months versus 12 months; P = 0.006), confirmed by multivariable analysis. The median progression‐free survival was shorter in patients who experienced a flare of preexisting autoimmune disease or other IRAE, with a trend toward better survival in the subgroup without immunosuppressant use or ICI discontinuation.ConclusionOur findings indicate that flares or IRAEs occur frequently but are mostly manageable without ICI discontinuation in patients with a preexisting autoimmune disease. Immunosuppressive therapy at baseline is associated with poorer outcomes.
- 2Immune-checkpoint inhibitor use in patients with cancer and pre-existing autoimmune diseases
Nature reviews. Rheumatology · 2022
📚 138 citations🎯 RCR 8.98Top 3% NIH - 3Baseline co-medications may alter the anti-tumoural effect of checkpoint inhibitors as well as the risk of immune-related adverse events
European journal of cancer (Oxford, England : 1990) · 2021
Publications scientifiques (25) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal13
▼
Transversal13
▼- Spondylodiscitis Caused by Tropheryma whipplei: Report of 2 Cases
The Journal of rheumatology · 2026 · Journal Article
Preuss P, Tison A, Cormier G, Puéchal X
- Usefulness of 18F-FDG PET-CT in detecting subclinical arteritis and cancer associated with polymyalgia rheumatica
Joint bone spine · 2026 · Journal Article
Le Madec A, Querellou S, Binard A, Saraux A, et al.
- B-Cell involvement in immune checkpoint inhibitor-induced lichen planus: A comparative analysis with non-drug-related lichen planus
The Journal of investigative dermatology · 2025 · Journal Article
Tison A, Legoupil D, Le Rochais M, Hémon P, et al.
- What can imaging teach us about immune checkpoint inhibitor-induced arthritis?
The Lancet. Rheumatology · 2025 · Journal Article
Tison A, Bass AR
- Immune Checkpoint Inhibitor-induced Polymyalgia Rheumatica
Rheumatic diseases clinics of North America · 2024 · Journal Article
Liew DFL, Mackie SL, Tison A, Sattui SE, et al.
📚 6 cit.🎯 RCR 1.80 - Detection of hypophosphatasia in hospitalised adults in rheumatology and internal medicine departments: a multicentre study over 10 years
RMD open · 2024 · Multicenter Study
Larid G, Vix J, Preuss P, Robin F, et al.
📚 6 cit.🎯 RCR 2.37🔬→🩺 Translationnel - Immune checkpoint inhibitor rechallenge in patients who previously experienced immune-related inflammatory arthritis: a multicentre observational study
RMD open · 2023 · Observational Study
Ladouceur A, Barnetche T, Mouterde G, Tison A, et al.
📚 5 cit.🩺 Clinique - Immune-checkpoint inhibitor use in patients with cancer and pre-existing autoimmune diseases
Nature reviews. Rheumatology · 2022 · Journal Article
Tison A, Garaud S, Chiche L, Cornec D, et al.
📚 138 cit.🎯 RCR 8.98🔬→🩺 Translationnel - Baseline co-medications may alter the anti-tumoural effect of checkpoint inhibitors as well as the risk of immune-related adverse events
European journal of cancer (Oxford, England : 1990) · 2021 · Journal Article
Kostine M, Mauric E, Tison A, Barnetche T, et al.
📚 80 cit.🎯 RCR 4.14🔬→🩺 Translationnel - Publisher Correction: Rheumatological features of Whipple disease
Scientific reports · 2021 · Published Erratum
Tison A, Preuss P, Leleu C, Robin F, et al.
- Rheumatological features of Whipple disease
Scientific reports · 2021 · Journal Article
Tison A, Preuss P, Leleu C, Robin F, et al.
📚 19 cit.🎯 RCR 1.65🔬→🩺 Translationnel - Reply
Arthritis & rheumatology (Hoboken, N.J.) · 2020 · Letter
Tison A, Kostine M, Cornec D
- Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple Disease
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019 · Letter
Tison A, Saraux A
📚 8 cit.
Épidémiologie & registres3
▼
Épidémiologie & registres3
▼- Oral glucocorticoid treatment for checkpoint inhibitor-associated inflammatory arthritis does not affect cancer progression-free survival: a RADIOS Registry study
Annals of the rheumatic diseases · 2026 · Journal Article
Jannat-Khah DP, Reid P, Cappelli LC, Suarez-Almazor ME, et al.
- Prevalence and Significance of the Presence of Anti-transglutaminase and Anti-endomysium Antibodies in Patients with Early Inflammatory Joint Disease
Rheumatology and therapy · 2025 · Journal Article
Bettacchioli E, Cornec D, Gardien P, Quenehervé L, et al.
📚 2 cit. - Safety and Efficacy of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease: A Nationwide, Multicenter Cohort Study
Arthritis & rheumatology (Hoboken, N.J.) · 2019 · Evaluation Study
Tison A, Quéré G, Misery L, Funck-Brentano E, et al.
📚 245 cit.🎯 RCR 9.65🔬→🩺 Translationnel
Revue générale3
▼
Revue générale3
▼- Practical management of rheumatic immune-related adverse events occurring with immune checkpoint inhibitors: A narrative review
Joint bone spine · 2026 · Journal Article
Tison A, Escoda T, Kostine M, Cornec D, et al.
📚 1 cit. - Rheumatic immune-and nonimmune-related adverse events in phase 3 clinical trials assessing PD-(L)1 checkpoint inhibitors for lung cancer: A systematic review and meta-analysis
Joint bone spine · 2022 · Journal Article
Veccia A, Kostine M, Tison A, Dipasquale M, et al.
📚 6 cit.🔬→🩺 Translationnel - Immune-checkpoint inhibitors to treat cancers in specific immunocompromised populations: a critical review
Expert review of anticancer therapy · 2018 · Journal Article
Babey H, Quéré G, Descourt R, Le Calloch R, et al.
📚 12 cit.
Sjögren3
▼
Sjögren3
▼- Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study
Rheumatology (Oxford, England) · 2025 · Journal Article
Tison A, Jousse-Joulin S, Consigny M, Moog P, et al.
- Association of Combined Anti-Ro52/TRIM21 and Anti-Ro60/SSA Antibodies With Increased Sjögren Disease Severity Through Interferon Pathway Activation
Arthritis & rheumatology (Hoboken, N.J.) · 2024 · Journal Article
Bettacchioli E, Saraux A, Tison A, Cornec D, et al.
📚 24 cit.🎯 RCR 4.97🔬→🩺 Translationnel - B cells in Sjögren's syndrome: from pathophysiology to therapeutic target
Rheumatology (Oxford, England) · 2021 · Journal Article
Mielle J, Tison A, Cornec D, Le Pottier L, et al.
📚 34 cit.🎯 RCR 2.41
Biothérapies non-anti-TNF2
▼
Biothérapies non-anti-TNF2
▼- [(18)F]FDG PET/CT for therapeutic assessment of Abatacept in early-onset polymyalgia rheumatica
European journal of nuclear medicine and molecular imaging · 2024 · Journal Article
Allard B, Devauchelle-Pensec V, Saraux A, Nowak E, et al.
📚 2 cit. - Abatacept in early polymyalgia rheumatica (ALORS): a proof-of-concept, randomised, placebo-controlled, parallel-group trial
The Lancet. Rheumatology · 2023 · Randomized Controlled Trial
Saraux A, Le Henaff C, Dernis E, Carvajal-Alegria G, et al.
📚 19 cit.🎯 RCR 2.63🩺 Clinique
Corticothérapie1
▼
Corticothérapie1
▼- Oral glucocorticoid treatment for checkpoint inhibitor-associated inflammatory arthritis does not affect cancer progression-free survival: a RADIOS Registry study
Annals of the rheumatic diseases · 2026 · Journal Article
Jannat-Khah DP, Reid P, Cappelli LC, Suarez-Almazor ME, et al.
JAK inhibiteurs1
▼
JAK inhibiteurs1
▼- Baricitinib in early polymyalgia rheumatica (BACHELOR): a randomised, double-blind, placebo-controlled, parallel-group trial
The Lancet. Rheumatology · 2025 · Clinical Trial, Phase II
Saraux A, Carvajal Alegria G, Dernis E, Roux C, et al.
📚 14 cit.🎯 RCR 5.85🩺 Clinique
Pharmacovigilance1
▼
Pharmacovigilance1
▼- Safety and Efficacy of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Disease: A Nationwide, Multicenter Cohort Study
Arthritis & rheumatology (Hoboken, N.J.) · 2019 · Evaluation Study
Tison A, Quéré G, Misery L, Funck-Brentano E, et al.
📚 245 cit.🎯 RCR 9.65🔬→🩺 Translationnel
Revue / méta-analyse1
▼
Revue / méta-analyse1
▼- Rheumatic immune-and nonimmune-related adverse events in phase 3 clinical trials assessing PD-(L)1 checkpoint inhibitors for lung cancer: A systematic review and meta-analysis
Joint bone spine · 2022 · Journal Article
Veccia A, Kostine M, Tison A, Dipasquale M, et al.
📚 6 cit.🔬→🩺 Translationnel
