📇 Rhumatologue · PARIS CEDEX 12 · (75) · Hospitalier

M DJILLALI SAHALI

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5 raisons identifiées

Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
29 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (5 thèses dirigées)
Expérience confirmée
35 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS CEDEX 12 (75)HospitalierRPPS 10000487545

EnseignementExpérience confirmée

35ans d'exercice (thèse 1991)

📊 Reconnaissance scientifique : 7/100📝 25 articles publiés🇫🇷 Publications académiques françaises (8)🎓 5 thèses dirigées

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Kidney diseases associated with anti-vascular endothelial growth factor (VEGF): an 8-year observational study at a single center

Medicine · 2014

📚 130 citations🎯 RCR 4.42Top 9% NIH🩺 Clinique🔓 Open Access

c-mip impairs podocyte proximal signaling and induces heavy proteinuria

Science signaling · 2010

📚 85 citations🎯 RCR 2.19Top 24% NIH🔓 Open Access

Lire l'abstract Crossref ↓

Overexpression of the protein c-mip in mice produces phenotypes similar to various idiopathic kidney disorders.

A novel approach to investigation of the pathogenesis of active minimal-change nephrotic syndrome using subtracted cDNA library screening

Journal of the American Society of Nephrology : JASN · 2002

📚 85 citations🎯 RCR 1.77🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

ABSTRACT. Clinical and experimental observations suggest that minimal-change nephrotic syndrome (MCNS) results from T cell dysfunction, via unknown mechanisms. For the identification of genes that are potentially involved in MCNS, a subtractive cDNA library was constructed from cDNA from T cell-enriched peripheral blood mononuclear cells obtained from the same patient during relapse versus remission (“relapse minus remission”). This library was screened by differential hybridization with forward (“relapse minus remission”) and reverse (“remission minus relapse”) subtractive cDNAs probes, as well as unsubtracted probes from relapse and remission, and irrelevant nephrotic syndrome (membranous nephropathy). A total of 84 transcripts were isolated, of which 12 matched proteins of unknown function and 30 were unknown clones. Among the 42 known transcripts, at least 18 are closely involved in the T cell receptor-mediated complex signaling cascade, including genes encoding components of the T cell receptor and proteins associated with the cytoskeletal scaffold, as well as transcription factors. In particular, it was demonstrated that the expression levels of Fyb/Slap, L-plastin, and grancalcin were increased during relapse, suggesting that the integration of proximal signaling after T cell engagement involves the preferential recruitment of these cytoskeleton-associated proteins in MCNS. Because very low levels of interleukin-12 receptor β2 mRNA were detected in relapse samples, the interleukin-12 signaling pathway might be defective, suggesting that, in MCNS, T cell activation evolves toward a T helper 2 phenotype. Therefore, the combination of subtractive cloning and differential screening constitutes an efficient approach to the identification of genes that are likely to be involved in the pathophysiologic processes of MCNS.

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M DJILLALI SAHALI

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Direction de thèses

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (29) — classées par pathologie

Transversal26

Biothérapies non-anti-TNF1

Case report / série1

Pédiatrie1

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