Professeur PIERRE MIOSSEC
Diplômes
🎓 DES & spécialité ordinale
- Rhumatologie (SM)
📚 CES (Certificat d'Études Spéciales)
- CES Rhumatologie
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Thèses universitaires
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Direction de thèses
🎓 6 thèses dirigéesInteractions entre cellules et facteurs solubles dans les maladies articulaires chroniques : compréhension et ciblage thérapeutique
2018Doctorant·e : Samira Filali
Biomolécules. Pharmacologie. Thérapeutique🎓 LyonIL - 17 et réponse inflammatoire systémique : focus sur le foie et le muscle
2018Doctorant·e : Audrey Beringer
Immunologie🎓 LyonIL-17/Th17 au cours de l'inflammation chronique : ciblage des interactions cellulaires
2016Doctorant·e : Melissa Noack
Immunologie🎓 LyonIL-17/Th17 au cours de l'inflammation chronique : ciblage des interactions cellulaires
2016Doctorant·e : Mélissa Noack
Biologie. Immunologie🎓 LyonChangement de l’homéostasie du Zinc et du Cadmium par l’inflammation chronique et nouvelles options thérapeutiques pour le traitement de l’arthrite
2016Doctorant·e : Paola Bonaventura
Immunologie🎓 LyonEffects of Interleukine-17A (Il-17A) and tumor necrosis factor alpha (TNF-α) on osteoblastic differentiation
2014Doctorant·e : Bilal Osta
Immunologie🎓 Lyon 1
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
74
h articles cités ≥ h fois chacun. Un h de 74 = 74 publications avec 74+ citations.
Citations
24 284
Publications
459
i10-index
246
Thématiques principales
- Rheumatoid Arthritis Research and Therapies ×185
- Psoriasis: Treatment and Pathogenesis ×81
- Systemic Lupus Erythematosus Research ×68
- Monoclonal and Polyclonal Antibodies Research ×51
- T-cell and B-cell Immunology ×48
Affiliations FR : Université Claude Bernard Lyon 1 · Hospices Civils de Lyon
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
Definition of clinical immunology around the globe
2025ArticleFrontiers in Immunology
Effects of pro-inflammatory cytokines and cell interactions on cell area and cytoskeleton of rheumatoid arthritis synoviocytes and immune cells
2023ArticleEuropean Journal of Cell Biology
Evaluation of the Performance of an Indirect Immunofluorescence Assay for the Detection of Anti-MDA5 Antibodies
2022ArticleBiomedicines
Synovial Extracellular Vesicles: Structure and Role in Synovial Fluid Tribological Performances
2022ArticleInternational Journal of Molecular Sciences
Morphological and Mechanical Characterization of Extracellular Vesicles and Parent Human Synoviocytes under Physiological and Inflammatory Conditions
2022ArticleInternational Journal of Molecular Sciences
Impact of Host Immune Status on Discordant Anti-SARS-CoV-2 Circulating B Cell Frequencies and Antibody Levels
2021ArticleInternational Journal of Molecular Sciences
Gastroenterological safety of IL-17 inhibitors: a systematic literature review
2021ArticleExpert Opinion on Drug Safety
Biological Applications and Toxicity Minimization of Semiconductor Quantum Dots
2020ArticleTrends in Biotechnology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Lieu de consultation
HOPITAL EDOUARD HERRIOT - HCL
5 Place D'ARSONVAL, 69437 Lyon 3e Arrondissement
☎ 0472117311Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)
Ageing research reviews · 2019
📚 139 citations🎯 RCR 7.09Top 4% NIH🩺 Clinique🔓 Open Access - 2The IL-23-IL-17 pathway as a therapeutic target in axial spondyloarthritis
Nature reviews. Rheumatology · 2019
📚 99 citations🎯 RCR 4.38Top 9% NIH - 3Evolving concepts of the pathogenesis of rheumatoid arthritis with focus on the early and late stages
Current opinion in rheumatology · 2020
📚 60 citations🎯 RCR 3.71Top 12% NIHLire l'abstract Crossref ↓
Purpose of review To provide an overview of recently published work covering key mechanisms involved in the pathogenesis of rheumatoid arthritis (RA), with focus on the early and late stages. Recent findings Present understanding of RA pathogenesis has been mainly focused on the inflammatory process at the established phase of the disease, but recent work has shed light on important molecular and cellular mechanisms involved both at the early and late/refractory stages. In early RA, the involvement of anticitrullinated protein antibodies in RA induction has been identified with a critical role of the IL-23/Th17 axis in the control of their pathogenicity. At the late stage, RA may be viewed as a cell-autonomous genetic and epigenetic disease, characterized by altered cell death pathways in synoviocytes after long-term exposure to inflammation. An improved knowledge of these cell-intrinsic altered pathways is the basis for the targeting of pathogenic synoviocytes, as a new therapeutic alternative against resistance to current treatment targeting the immune system. Summary We summarize these pathological pathways, and their understanding will facilitate the design of new diagnostic tools and therapeutic strategies combining the targeting of pathogenic synoviocytes with current immune-targeted therapies.
Publications scientifiques (50) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal40
▼
Transversal40
▼- Rheumatoid arthritis: revisiting pathogenesis for prevention, stratification, and repair
Current opinion in immunology · 2026 · Journal Article
Coutant F, Miossec P
- Understanding Cardiovascular Events With JAK Inhibitors: Similarities and Differences of the Vascular Effects Between Different JAK Inhibitors on Endothelial Cells Exposed to Inflammatory Cytokines
ACR open rheumatology · 2025 · Journal Article
Zavoriti A, Miossec P
📚 1 cit. - Understanding the effects of Janus kinase inhibitors on the cardiovascular system in comparison to main biological DMARDs in rheumatoid arthritis
Autoimmunity reviews · 2025 · Journal Article
Zavoriti A, Miossec P
📚 2 cit. - IFNγ production during cell interactions distinguishes localized from diffuse pigmented villonodular synovitis and rheumatoid arthritis
Arthritis research & therapy · 2025 · Journal Article
Noack M, Miossec P
📚 1 cit. - Definition of clinical immunology around the globe
Frontiers in immunology · 2025 · Journal Article
Crispín JC, Cantaert T, Pinzon-Charry A, Mavilio D, et al.
- Neutralizing and enhancing monoclonal antibodies in SARS-CoV-2 convalescent patients: lessons from early variant infection and impact on shaping emerging variants
Emerging microbes & infections · 2024 · Journal Article
Coutant F, Touret F, Pin JJ, Alonzo M, et al.
📚 4 cit. - [IL-17A and IL-17F: from discovery to target of biologics - an illustrative example of translational research]
Biologie aujourd'hui · 2024 · Journal Article
Robert M, Miossec P
📚 1 cit. - Differential effects of interleukin-17A and 17F on cell interactions between immune cells and stromal cells from synovium or skin
Scientific reports · 2023 · Journal Article
Tout I, Noack M, Miossec P
📚 10 cit.🎯 RCR 1.37 - Cryofibrinogen-Characteristics and Association with Cryoglobulin: A Retrospective Study Out of a Series of 1,712 Samples over 7 Years
Thrombosis and haemostasis · 2023 · Journal Article
Sarda-Kolopp MN, Miossec P
📚 4 cit. - Heterogeneous effects of S100 proteins during cell interactions between immune cells and stromal cells from synovium or skin
Clinical and experimental immunology · 2023 · Journal Article
Noack M, Miossec P
📚 2 cit. - Effects of pro-inflammatory cytokines and cell interactions on cell area and cytoskeleton of rheumatoid arthritis synoviocytes and immune cells
European journal of cell biology · 2023 · Journal Article
Filali S, Noack M, Géloën A, Pirot F, et al.
📚 10 cit.🎯 RCR 1.16 - Editorial: Insights in inflammation: 2022
Frontiers in immunology · 2023 · Editorial
Ghezzi P, Lucas R, Mader S, Miossec P, et al.
📚 1 cit. - Evaluation of the Performance of an Indirect Immunofluorescence Assay for the Detection of Anti-MDA5 Antibodies
Biomedicines · 2022 · Journal Article
Nombel A, Pin JJ, Fabien N, Miossec P, et al.
📚 2 cit. - Morphological and Mechanical Characterization of Extracellular Vesicles and Parent Human Synoviocytes under Physiological and Inflammatory Conditions
International journal of molecular sciences · 2022 · Journal Article
Filali S, Darragi-Raies N, Ben-Trad L, Piednoir A, et al.
📚 6 cit.🔬→🩺 Translationnel - Synovial Extracellular Vesicles: Structure and Role in Synovial Fluid Tribological Performances
International journal of molecular sciences · 2022 · Journal Article
Ben-Trad L, Matei CI, Sava MM, Filali S, et al.
📚 14 cit.🎯 RCR 1.73 - Monoclonal antibodies from B cells of patients with anti-MDA5 antibody-positive dermatomyositis directly stimulate interferon gamma production
Journal of autoimmunity · 2022 · Journal Article
Coutant F, Bachet R, Pin JJ, Alonzo M, et al.
📚 33 cit.🎯 RCR 2.94 - The role of B cells and their interactions with stromal cells in the context of inflammatory autoimmune diseases
Autoimmunity reviews · 2022 · Journal Article
Tout I, Miossec P
📚 14 cit.🎯 RCR 1.13🔬→🩺 Translationnel - The Th17 Pathway in Vascular Inflammation: Culprit or Consort?
Frontiers in immunology · 2022 · Journal Article
Robert M, Miossec P, Hot A
📚 33 cit.🎯 RCR 3.01🔬→🩺 Translationnel - Synoviocytes from pigmented villonodular synovitis are less sensitive to cadmium-induced cell death than synoviocytes from rheumatoid arthritis
Scientific reports · 2022 · Journal Article
Farese H, Noack M, Miossec P
📚 9 cit.🎯 RCR 1.16 - Practical Details for the Detection and Interpretation of Cryoglobulins
Clinical chemistry · 2022 · Journal Article
Kolopp-Sarda MN, Miossec P
📚 10 cit.🎯 RCR 1.20 - Addition of Fibroblast-Stromal Cell Markers to Immune Synovium Pathotypes Better Predicts Radiographic Progression at 1 Year in Active Rheumatoid Arthritis
Frontiers in immunology · 2021 · Journal Article
Zhang XP, Ma JD, Mo YQ, Jing J, et al.
📚 9 cit. - Key points to consider for an improved detection and characterization of cryoglobulins
Autoimmunity reviews · 2021 · Letter
Kolopp-Sarda MN, Miossec P
- Impact of Host Immune Status on Discordant Anti-SARS-CoV-2 Circulating B Cell Frequencies and Antibody Levels
International journal of molecular sciences · 2021 · Journal Article
Coutant F, Pin JJ, Morfin-Sherpa F, Ferry T, et al.
📚 3 cit. - Importance of lymphocyte-stromal cell interactions in autoimmune and inflammatory rheumatic diseases
Nature reviews. Rheumatology · 2021 · Journal Article
Noack M, Miossec P
📚 42 cit.🎯 RCR 2.32 - Extensive Phenotype of Human Inflammatory Monocyte-Derived Dendritic Cells
Cells · 2021 · Journal Article
Coutant F, Pin JJ, Miossec P
📚 14 cit. - Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor
Cellular & molecular immunology · 2021 · Journal Article
Robert M, Miossec P
📚 46 cit.🎯 RCR 3.47🔬→🩺 Translationnel - High oligoclonality of immunoglobulins in SARS-CoV2 positive patients
Annals of the rheumatic diseases · 2021 · Letter
Kolopp-Sarda M, Miossec P
📚 1 cit. - Cryoglobulinemic vasculitis: pathophysiological mechanisms and diagnosis
Current opinion in rheumatology · 2021 · Journal Article
Kolopp-Sarda MN, Miossec P
📚 29 cit.🎯 RCR 2.82 - Synergy Between Cytokines and Risk Factors in the Cytokine Storm of COVID-19: Does Ongoing Use of Cytokine Inhibitors Have a Protective Effect?
Arthritis & rheumatology (Hoboken, N.J.) · 2020 · Editorial
Miossec P
📚 5 cit. - IgG subclasses in cryoglobulins: link to composition and clinical manifestations
Arthritis research & therapy · 2020 · Journal Article
Kolopp-Sarda MN, Azevedo PM, Miossec P
📚 5 cit. - Reply
Arthritis & rheumatology (Hoboken, N.J.) · 2020 · Letter
Kolopp-Sarda MN, Miossec P
- Joint Destruction Is Associated With All Types of Cardiovascular Events in French Rheumatoid Patients: A Real-Life Study With Very Long Follow-Up
Frontiers in medicine · 2020 · Journal Article
Robert M, Hot A, Mifsud F, Ndongo-Thiam N, et al.
📚 2 cit. - Synergistic Interaction Between High Bioactive IL-17A and Joint Destruction for the Occurrence of Cardiovascular Events in Rheumatoid Arthritis
Frontiers in immunology · 2020 · Journal Article
Robert M, Hot A, Mifsud F, Ndongo-Thiam N, et al.
📚 12 cit. - Reduced skeletal muscle independently predicts 1-year aggravated joint destruction in patients with rheumatoid arthritis
Therapeutic advances in musculoskeletal disease · 2020 · Journal Article
Lin JZ, Liu Y, Ma JD, Mo YQ, et al.
📚 16 cit.🔬→🩺 Translationnel - Understanding the cytokine storm during COVID-19: Contribution of preexisting chronic inflammation
European journal of rheumatology · 2020 · Journal Article
Miossec P
📚 16 cit.🔬→🩺 Translationnel - Contribution of Hepatitis C Infection to a Large Cohort of Cryoglobulin-Positive Patients: Detection and Characteristics
Frontiers in immunology · 2020 · Journal Article
Kolopp-Sarda MN, Miossec P
📚 6 cit. - Biological Applications and Toxicity Minimization of Semiconductor Quantum Dots
Trends in biotechnology · 2020 · Journal Article
Filali S, Pirot F, Miossec P
📚 59 cit.🎯 RCR 3.69 - Interleukin-17 and lupus: enough to be a target? For which patients?
Lupus · 2020 · Journal Article
Robert M, Miossec P
📚 36 cit.🎯 RCR 1.90🔬→🩺 Translationnel - Evolving concepts of the pathogenesis of rheumatoid arthritis with focus on the early and late stages
Current opinion in rheumatology · 2020 · Journal Article
Coutant F, Miossec P
📚 60 cit.🎯 RCR 3.71🔬→🩺 Translationnel - Cryoglobulins Today: Detection and Immunologic Characteristics of 1,675 Positive Samples From 13,439 Patients Obtained Over Six Years
Arthritis & rheumatology (Hoboken, N.J.) · 2019 · Journal Article
Kolopp-Sarda MN, Nombel A, Miossec P
📚 27 cit.🎯 RCR 1.29🔬→🩺 Translationnel
Anti-IL-174
▼
Anti-IL-174
▼- Role of a new truncated CD74 isoform in increased IL-17 secretion from stromal-immune cell interactions
Clinical and experimental immunology · 2025 · Journal Article
Noack M, Bailly M, Durix L, Pin JJ, et al.
📚 1 cit. - Gastroenterological safety of IL-17 inhibitors: a systematic literature review
Expert opinion on drug safety · 2022 · Journal Article
Caron B, Jouzeau JY, Miossec P, Petitpain N, et al.
📚 27 cit.🎯 RCR 2.67🔬→🩺 Translationnel - Local and systemic effects of IL-17 in joint inflammation: a historical perspective from discovery to targeting
Cellular & molecular immunology · 2021 · Journal Article
Miossec P
📚 43 cit.🎯 RCR 2.99 - The IL-23-IL-17 pathway as a therapeutic target in axial spondyloarthritis
Nature reviews. Rheumatology · 2019 · Journal Article
Sieper J, Poddubnyy D, Miossec P
📚 99 cit.🎯 RCR 4.38🔬→🩺 Translationnel
Anti-IL-233
▼
Anti-IL-233
▼- Structural cell heterogeneity underlies the differential contribution of IL-17A, IL-17F and IL-23 to joint versus skin chronic inflammation
Autoimmunity reviews · 2024 · Journal Article
Robert M, Miossec P
📚 11 cit.🎯 RCR 2.36 - Synoviocytes and skin fibroblasts show opposite effects on IL-23 production and IL-23 receptor expression during cell interactions with immune cells
Arthritis research & therapy · 2022 · Journal Article
Noack M, Miossec P
📚 9 cit. - The IL-23-IL-17 pathway as a therapeutic target in axial spondyloarthritis
Nature reviews. Rheumatology · 2019 · Journal Article
Sieper J, Poddubnyy D, Miossec P
📚 99 cit.🎯 RCR 4.38🔬→🩺 Translationnel
csDMARDs1
▼
csDMARDs1
▼- Effects of Methotrexate Alone or Combined With Arthritis-Related Biotherapies in an in vitro Co-culture Model With Immune Cells and Synoviocytes
Frontiers in immunology · 2019 · Journal Article
Noack M, Miossec P
📚 12 cit.🔬→🩺 Translationnel
Économie santé1
▼
Économie santé1
▼- Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)
Ageing research reviews · 2019 · Journal Article
Biver E, Berenbaum F, Valdes AM, Araujo de Carvalho I, et al.
📚 139 cit.🎯 RCR 7.09🩺 Clinique
JAK inhibiteurs1
▼
JAK inhibiteurs1
▼- Understanding Cardiovascular Events With JAK Inhibitors: Tofacitinib Reduces Synovial and Vascular Inflammation but not the Prothrombotic Effects of Inflammatory Cytokines on Endothelium
ACR open rheumatology · 2025 · Journal Article
Zavoriti A, Miossec P
📚 7 cit.🎯 RCR 3.11🔬→🩺 Translationnel
Microbiote1
▼
Microbiote1
▼- Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)
Ageing research reviews · 2019 · Journal Article
Biver E, Berenbaum F, Valdes AM, Araujo de Carvalho I, et al.
📚 139 cit.🎯 RCR 7.09🩺 Clinique
Recommandations1
▼
Recommandations1
▼- Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)
Ageing research reviews · 2019 · Journal Article
Biver E, Berenbaum F, Valdes AM, Araujo de Carvalho I, et al.
📚 139 cit.🎯 RCR 7.09🩺 Clinique
Revue générale1
▼
Revue générale1
▼- Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features
Frontiers in immunology · 2022 · Research Support, Non-U.S. Gov't
Robert M, Farese H, Miossec P
📚 29 cit.🎯 RCR 3.82🔬→🩺 Translationnel
Datasets & protocoles partagés
Effect of exogenous IL-17 on IL-6 production by RA synovium
Image2011figshare<b>Copyright information:</b>Taken from "IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis"Arthritis Research 2001;3(3):168-177.Published online 26 Jan 2001PMCI
Link between changes in IL-6 and osteoprotegerin (OPG) production by rheumatoid arthritis (RA) synoviocytes and clinical response
Image2011figshare<b>Copyright information:</b>Taken from "Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical response"Arthritis Research & Therapy 2004;7(1):R14
Effect of exogenous IL-17 on type I collagen metabolism by RA bone explants
Image2011figshare<b>Copyright information:</b>Taken from "IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis"Arthritis Research 2001;3(3):168-177.Published online 26 Jan 2001PMCI
Respective contribution of endogenous IL-17 to synovium and bone destruction
Image2011figshare<b>Copyright information:</b>Taken from "IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis"Arthritis Research 2001;3(3):168-177.Published online 26 Jan 2001PMCI
Effects of IL-1β, tumor necrosis factor alpha (TNF-α) and IL-17 used alone and in combination on c-mRNA expression
Image2011figshare<b>Copyright information:</b>Taken from "Increased AP-1 and NF-κB activation and recruitment with the combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes"A
Quantification of the effects of individual cytokines and their combinations on TF nuclear translocation
Image2011figshare<b>Copyright information:</b>Taken from "Increased AP-1 and NF-κB activation and recruitment with the combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes"A
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
