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RhumatologueMédecins généralistes et spécialistes👤 Libéral intégral

M. Docteur Jean-Marc METZGER

📍 Strasbourg (67)Libéral💶 Secteur 2RPPS 10002414612
📊 Reconnaissance scientifique : 25/100📝 176 articles publiés📚 HAL (8)🏆 1 DU/DIU

Diplômes

🎓 DES & spécialité ordinale

  • Rhumatologie (SM)

📚 CES (Certificat d'Études Spéciales)

  • CES Médecine appliquée aux sports
  • CES Rhumatologie

🎯 Capacités

  • Médecine appliquée aux sports (C)

🎓 Diplômes

  • DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

🏆 Diplômes complémentaires reconnus

  • CES Médecine du sportCapacité

    Formation à la traumatologie sportive et à la médecine du sport. Très utile pour rhumatos en cabinet libéral qui suivent des sportifs (amateurs ou pros).

    Capacité reconnue par le Conseil de l'Ordre

    Page d'information générale →

Activité de recherche & publications

Source : bases de données publiques (OpenAlex, PubMed).

h-index

25

h articles cités ≥ h fois chacun. Un h de 25 = 25 publications avec 25+ citations.

Citations

2 202

Publications

176

i10-index

46

Thématiques principales

  • Atmospheric Ozone and Climate ×104
  • Atmospheric chemistry and aerosols ×87
  • Atmospheric and Environmental Gas Dynamics ×57
  • Atmospheric aerosols and clouds ×44
  • Spectroscopy and Laser Applications ×18
Voir sur OpenAlex ↗🆔 ORCID 0000-0002-6291-6677

Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.

Bibliographie

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Localisation

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieu de consultation

Tarifs & secteur de conventionnement

🟡 Secteur 2 — Honoraires libresSource CNAM (Annuaire santé Ameli)
✓ OPTAM💳 Carte VitaleLibéral intégral
📊 Comprendre le remboursement

Prendre rendez-vous & contact

🗓 Trouver sur Doctolib📇 Ajouter à mes contacts

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (2)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Top publications · les plus citées

  • 1
    Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner

    European journal of immunology · 2004

    📚 408 citations🎯 RCR 8.01Top 4% NIH🔓 Open Access📄 PDF gratuit ↗
    Lire l'abstract Crossref ↓

    AbstractToll‐like receptors (TLR) recognize bacterial and viral components, but direct interaction of receptor and ligand is unclear. Here, we demonstrate that TLR9 binds directly and sequence‐specifically to single‐stranded unmethylated CpG‐DNA containing a phosphodiester backbone. TLR9‐CpG‐DNA interaction occurs at the acidic pH (6.5–5.0) found in endosomes and lysosomes. By sequence comparison we identified a potential CpG‐DNA binding domain homologous to that described for methyl‐CpG‐DNA binding proteins. Amino acid substitutions in this region abrogated CpG‐DNA binding and led to loss of NF‐κB activation. Furthermore, chloroquine and quinacrine, therapeutic agents for autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus, directly blocked TLR9‐CpG‐DNA interaction but not TLR2‐Pam3Cys binding. Our results demonstrate direct binding of TLR9 to CpG‐DNA and suggest that the therapeutic activity of chloroquine and quinacrine in autoimmune diseases may be due to its activity as a TLR9 antagonist and inhibitor of endosomal acidification.

  • 2
    Biosensor analysis of beta2-glycoprotein I-reactive autoantibodies: evidence for isotype-specific binding and differentiation of pathogenic from infection-induced antibodies

    Clinical chemistry · 2007

    📚 38 citations🎯 RCR 1.19
    Lire l'abstract Crossref ↓

    Abstract Background: For the laboratory diagnosis of the antiphospholipid syndrome (APS) we developed a biosensor with the ability to distinguish between disease-relevant anti-β2-glycoprotein I (β2GPI) autoantibodies (anti-β2GPI) and pathogen-specific β2GPI cross-reactive antibodies that occur transiently during infections. Methods: We used a surface plasmon resonance (SPR) biosensor device. For the detection of anti-β2GPI in serum samples, affinity-purified human β2GPI was covalently attached to a functionalized n-alkanethiol self-assembling monolayer on the biosensor chip. After verifying the specificity of the biosensor system with a panel of monoclonal antibodies to β2GPI, we analyzed sera from healthy donors and patients suffering from APS, systemic lupus erythematosus (SLE), syphilis, or parvovirus B19 infections. The SPR results were compared with β2GPI-specific ELISA. Results: Using the SPR biosensor, we recorded antigen binding curves with response levels in the range of 50–500, resonance units (RU) for anti-β2GPI ELISA-positive APS patient sera. The amplitudes of the antiphospholipid antibody (APL) responses in the biosensor correlated with the overall IgG and IgM anti-β2GPI ELISA titers with a correlation coefficient of 0.87. Moreover, we observed immunoglobulin isotype-specific association and dissociation profiles for APL binding of different APS patient sera to the biosensor-immobilized β2GPI. In contrast to APS patient samples, no significant anti-β2GPI binding (response levels <35 RU) was observed in samples from healthy individuals or from patients suffering from SLE, syphilis, or parvovirus B19 infection. Conclusions: The SPR biosensor system enables specific detection of APS-associated β2GPI-reactive APL and differentiation from β2GPI cross-reactive antibodies that occur frequently during acute infections. The established association/dissociation plot for anti-β2GPI responses in APS patient sera gives additional information regarding the influence of anti-β2GPI IgG and IgM isotype distribution.

  • 3
    Novel biosensor-based analytic device for the detection of anti-double-stranded DNA antibodies

    Clinical chemistry · 2007

    📚 30 citations🔓 Open Access📄 PDF gratuit ↗
    Lire l'abstract Crossref ↓

    AbstractBackground: Patients with systemic lupus erythematosus (SLE) develop a wide variety of serologic manifestations, including double-stranded DNA autoantibodies (anti-dsDNA). The determination of the potentially pathogenic autoantibodies is diagnostically relevant.Methods: We developed a novel surface plasmon resonance (SPR) biosensor chip for studies of dsDNA and anti-dsDNA binding. A synthetic oligonucleotide was coupled to biotinylated human transferrin, hybridized with the complementary antistrand, and ligated with a human recombinant dsDNA fragment 233 bp in length. After surface immobilization of this antigenic construct, diluted sera from SLE patients and healthy donors were analyzed with the resulting SPR biosensor system.Results: This SPR biosensor allowed specific detection of anti-dsDNA. In pilot experiments, sera from SLE patients were distinguished from control sera. We also confirmed the specificity of this biosensor by supplementing anti-dsDNA–positive sera with salmon sperm DNA, which blocked the surface binding of anti-dsDNA in a concentration-dependent manner.Conclusions: An SPR biosensor monitors interactions in real time under homogeneous conditions, providing information about binding kinetics and affinities. Its applicability critically depends on the design of the solid-state surface of the sensor chips. Covalently immobilizing dsDNA as the antigen to the surface in a flow-through cell assured maximal stability for multiple serum injections and regeneration cycles. This technique, which adds a new analytic quality to existing methods, may be beneficial in the diagnosis and clinical monitoring of SLE.

Publications scientifiques (19) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Transversal14

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Lupus3

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Fièvres auto-inflammatoires1

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Génétique1

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SAPL1

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Datasets & protocoles partagés

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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