Docteur Carole METZGER

Localisation

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieux de consultation

• CLINIQUE DE MEUDON LA FORET

  3-5 — 3 Avenue DE VILLACOUBLAY, 92360 Meudon

  ☎ 0141281000Hospitalier🏥 Voir cet établissement
  © OpenStreetMap

  📷 Street View ↗🗺️ Maps ↗OSM ↗

• GHU APHP CUP SITE COCHIN PORT ROYAL

  27 Rue DU FAUBOURG SAINT JACQUES, 75679 Paris 14e Arrondissement

  ☎ 0158414141Hospitalier🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Changes in Bone Quality after Treatment with Etelcalcetide

  Clinical journal of the American Society of Nephrology : CJASN · 2023

  📚 22 citations🎯 RCR 4.60Top 9% NIH🔓 Open Access

  Lire l'abstract Crossref ↓

  Introduction Secondary hyperparathyroidism is associated with osteoporosis and fractures. Etelcalcetide is an intravenous calcimimetic for the control of hyperparathyroidism in patients on hemodialysis. Effects of etelcalcetide on the skeleton are unknown. Methods In a single-arm, open-label, 36-week prospective trial, we hypothesized that etelcalcetide improves bone quality and strength without damaging bone–tissue quality. Participants were 18 years or older, on hemodialysis ≥1 year, without calcimimetic exposure within 12 weeks of enrollment. We measured pretreatment and post-treatment areal bone mineral density by dual-energy X-ray absorptiometry, central skeleton trabecular microarchitecture by trabecular bone score, and peripheral skeleton volumetric bone density, geometry, microarchitecture, and estimated strength by high-resolution peripheral quantitative computed tomography. Bone–tissue quality was assessed using quadruple-label bone biopsy in a subset of patients. Paired t tests were used in our analysis. Results Twenty-two participants were enrolled; 13 completed follow-up (mean±SD age 51±14 years, 53% male, and 15% White). Five underwent bone biopsy (mean±SD age 52±16 years and 80% female). Over 36 weeks, parathyroid hormone levels declined 67%±9% (P < 0.001); areal bone mineral density at the spine, femoral neck, and total hip increased 3%±1%, 7%±2%, and 3%±1%, respectively (P < 0.05); spine trabecular bone score increased 10%±2% (P < 0.001); and radius stiffness and failure load trended to a 7%±4% (P = 0.05) and 6%±4% increase (P = 0.06), respectively. Bone biopsy demonstrated a decreased bone formation rate (mean difference −25±4 µm3/µm2 per year; P < 0.01). Conclusions Treatment with etelcalcetide for 36 weeks was associated with improvements in central skeleton areal bone mineral density and trabecular quality and lowered bone turnover without affecting bone material properties. Clinical Trial registry name and registration number: The Effect of Etelcalcetide on CKD-MBD (Parsabiv-MBD), NCT03960437

• 2

  Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease

  Frontiers in endocrinology · 2023

  📚 22 citations🎯 RCR 2.73Top 18% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Introduction Due to a lack of spatial-temporal resolution at the single cell level, the etiologies of the bone dysfunction caused by diseases such as normal aging, osteoporosis, and the metabolic bone disease associated with chronic kidney disease (CKD) remain largely unknown. Methods To this end, flow cytometry and scRNAseq were performed on long bone cells from Sost-cre/Ai9 + mice, and pure osteolineage transcriptomes were identified, including novel osteocyte-specific gene sets. Results Clustering analysis isolated osteoblast precursors that expressed Tnc , Mmp13 , and Spp1 , and a mature osteoblast population defined by Smpd3 , Col1a1 , and Col11a1 . Osteocytes were demarcated by Cd109 , Ptprz1 , Ramp1, Bambi, Adamts14 , Spns2, Bmp2 , WasI , and Phex . We validated our in vivo scRNAseq using integrative in vitro promoter occupancy via ATACseq coupled with transcriptomic analyses of a conditional, temporally differentiated MSC cell line. Further, trajectory analyses predicted osteoblast-to-osteocyte transitions via defined pathways associated with a distinct metabolic shift as determined by single-cell flux estimation analysis (scFEA). Using the adenine mouse model of CKD, at a time point prior to major skeletal alterations, we found that gene expression within all stages of the osteolineage was disturbed. Conclusion In sum, distinct populations of osteoblasts/osteocytes were defined at the single cell level. Using this roadmap of gene assembly, we demonstrated unrealized molecular defects across multiple bone cell populations in a mouse model of CKD, and our collective results suggest a potentially earlier and more broad bone pathology in this disease than previously recognized.

• 3

  Efficacy of a single, image-guided corticosteroid injection for glenohumeral arthritis

  Journal of shoulder and elbow surgery · 2021

  📚 16 citations🎯 RCR 1.81

Publications scientifiques (11) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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