Docteur Alexandre MERCIER

Bibliographie

• Skeletal Muscle and Circulating microRNAs Adaptations to 12‐Week HIIT With or Without L‐Citrulline in Obese Older Adults

  2026

  ArticleJournal of Cachexia, Sarcopenia and Muscle

• Clustering reveals diagnostic overlap between Still’s disease and a hyperinflammatory subset of seronegative rheumatoid arthritis

  2026

  ArticleScientific Reports

• Evaluation of circulating microRNA signature in patients with erosive hand osteoarthritis: The HOAmiR study

  2024

  ArticleOsteoarthritis and Cartilage

• Dysregulation of MicroRNAs in Adult Osteogenesis Imperfecta: The miROI Study

  2023

  ArticleJournal of Bone and Mineral Research

• Technologies de l'industrie 4.0 applicables à la chasse aux gaspillages du lean manufacturing

  2023

  Congrès18ème colloque national S.mart

• Réponse sérologique après vaccination contre le coronavirus chez les patients atteints de rhumatisme inflammatoire chronique traités par DMARDs : étude de cohorte et revue systématique avec méta-analyse

  2022

  ArticleRevue du Rhumatisme

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Livres & ouvrages

• 📕

  La Lutte anti-contrefaçon médicamenteuse en France

  2014 · 51 p.

Source : Google Books — filtre catégories médicales/santé/sciences.

Lieu de consultation

• HOPITAL EDOUARD HERRIOT - HCL

  5 Place D'ARSONVAL, 69437 Lyon 3e Arrondissement

  ☎ 0472117311Hospitalier🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Rapid Turnover of Hepatitis B Virus Covalently Closed Circular DNA Indicated by Monitoring Emergence and Reversion of Signature-Mutation in Treated Chronic Hepatitis B Patients

  Hepatology (Baltimore, Md.) · 2021

  📚 78 citations🎯 RCR 5.05Top 8% NIH🩺 Clinique🔓 Open Access

  Lire l'abstract Crossref ↓

  Background and Aims Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) plays a pivotal role in the establishment and persistence of HBV infection. Understanding the turnover time of preexisting cccDNA pools would be helpful in designing strategies to clear HBV by fully blocking the de novo generation of cccDNA. Approach and Results In this study, we retrospectively monitored the emergence and reversion of the rtM204I/V mutant, a signature lamivudine resistance (LAMR) mutation serving as a biomarker of cccDNA turnover in liver biopsies and longitudinal serum samples from two clinical trials. Methodologies were optimized to differentially isolate and sequence HBV virion DNA, cccDNA, and HBV RNA from clinical samples. A strong correlation was observed between LAMR composition of cccDNA with that of serum and intrahepatic HBV RNA in paired liver and serum samples (r = 0.96 and 0.90, respectively), suggesting that serum HBV RNA can serve as a surrogate marker of cccDNA genetic composition when liver biopsies are unavailable. LAMR mutations emerged and increased from undetectable to 40%‐90% within 16‐28 weeks in serum HBV RNA from telbivudine‐treated patients experiencing virological breakthrough. Similarly, in lamivudine‐resistant patients who switched to interferon therapy, serum HBV‐RNA population bearing 100% LAMR mutations fully reversed back to wild type within 24‐48 weeks. Conclusions The genetic composition dynamics of serum HBV RNA and biopsy cccDNA in treated HBV patients indicates that cccDNA turnover occurs relatively rapidly (several months), offering a possibility of HBV cure with finite therapy through completely blocking cccDNA replenishment.

• 2

  Both Php4 function and subcellular localization are regulated by iron via a multistep mechanism involving the glutaredoxin Grx4 and the exportin Crm1

  The Journal of biological chemistry · 2009

  📚 68 citations🎯 RCR 1.69🔓 Open Access📄 PDF gratuit ↗
• 3

  Evidence of prescription of antidepressants for non-psychiatric conditions in primary care: an analysis of guidelines and systematic reviews

  BMC family practice · 2013

  📚 51 citations🎯 RCR 2.22Top 24% NIH🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (10) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• Software Campus 2.0 (TU München)

  Report2026Hannover : Technische Informationsbibliothek

  Ausgewiesenes Ziel des Qualifizierungsprogramms ”Software Campus 2.0” ist die Fortführung der gemeinsamen Elitenförderung zur Aus- und Weiterbildung für hochqualifizierte Master- und Promotionsstudierende im Fach Informa

• Hidden State Poisoning Attacks against Mamba-based Language Models

  Preprint2026arXiv

  State space models (SSMs) like Mamba offer efficient alternatives to Transformer-based language models, with linear time complexity. Yet, their adversarial robustness remains critically unexplored. This paper studies the

• JaccDiv: A Metric and Benchmark for Quantifying Diversity of Generated Marketing Text in the Music Industry

  Preprint2025arXiv

  Online platforms are increasingly interested in using Data-to-Text technologies to generate content and help their users. Unfortunately, traditional generative methods often fall into repetitive patterns, resulting in mo

• CLASP: Defending Hybrid Large Language Models Against Hidden State Poisoning Attacks

  Preprint2026arXiv

  State space models (SSMs) like Mamba have gained significant traction as efficient alternatives to Transformers, achieving linear complexity while maintaining competitive performance. However, Hidden State Poisoning Atta

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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