Mme Docteur Marie LAFFAIRE

Localisation des cabinets

Adresses géocodées via la Base Adresse Nationale (api-adresse.data.gouv.fr). Précision indicative.

Lieux de consultation

• CABINET DE RHUMATOLOGIE DES DOCTEURS BERNARD-GENOT VIVARD ET BAZIN-HENRY

  26 RUE DE LA POLOGNE, 54300 Lunéville

  Libéral
  © OpenStreetMap

  📷 Street View ↗🗺️ Maps ↗OSM ↗

• CABINET DE RHUMATOLOGIE DES DOCTEURS BERNARD-GENOT VIVARD ET BAZIN-HENRY

  POLE MEDICAL KLEBER — 42 RUE DU 8 MAI 1945, 54270 Essey-lès-Nancy

  Libéral
  © OpenStreetMap

  📷 Street View ↗🗺️ Maps ↗OSM ↗

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009

  📚 798 citations🎯 RCR 19.50Top 1% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Purpose Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at codon 132 have been found in 12% of glioblastomas. Patients and Methods IDH1 codon 132 sequencing was performed in a series of 404 patients with glioma (100 grade 2, 121 grade 3, and 183 grade 4 gliomas) and correlated with histology, genomic profile, methylguanyl methyltransferase (MGMT) promoter methylation status, and outcome. Results A total of 155 codon 132 mutations were found, of which 131 were Arg132His (88.5%). The IDH1 mutation was inversely correlated with grade, affecting 77% of grade 2, 55% of grade 3, and 6% of grade 4 gliomas (P < 10 −15 ). The IDH1 mutation was tightly associated with a 1p19q codeleted genotype (P < 10 −14 ) and an MGMT methylated status (P < .001) but mutually exclusive with EGFR amplification (P < 10 −15 ) and loss of chromosome 10 (P < 10 −15 ). The presence (v absence) of IDH1 mutation was associated with a better outcome in grade 2 (150.9 v 60.1 months, respectively; P = .01), grade 3 (81.1 v 19.4 months, respectively; P < .001), and grade 4 gliomas (27.4 v 14 months, respectively; P < .01). After adjustment for grade, age, MGMT status, genomic profile, and treatment, multivariate analysis confirmed that IDH1 mutation was an independent favorable prognostic marker (hazard ratio = 0.297; 95% CI, 0.157 to 0.564, P = .00021). Conclusion This study indicates that IDH1 codon 132 mutation is closely linked to the genomic profile of the tumor and constitutes an important prognostic marker in grade 2 to 4 gliomas.

• 2

  All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2

  Neurology · 2010

  📚 223 citations🎯 RCR 5.32Top 7% NIH
• 3

  Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis

  Neuro-oncology · 2011

  📚 97 citations🎯 RCR 2.21Top 24% NIH🔓 Open Access📄 PDF gratuit ↗

Publications scientifiques (5) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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