📇 Rhumatologue ·

M MAX HASSAN

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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

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Top publications · les plus citées

Integrating natural products with modern medicine in the treatment of gouty arthritis: a review

Inflammopharmacology · 2025

📚 8 citations🎯 RCR 3.77🔓 Open Access📄 PDF gratuit ↗

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Abstract Gout is an inflammatory form of arthritis caused by hyperuricemia, a condition in which uric acid levels in the body become excessively high. When this occurs, monosodium urate (MSU) crystals can accumulate in the joints, triggering intense pain, swelling, and inflammation. If left untreated, gout can lead to joint damage and other complications. Diet is a key factor in the development and management of gout since some meals may increase uric acid levels while others can help relieve symptoms. To reduce circulating urate levels, commonly used drugs include allopurinol and febuxostat. However, the intake of these medications is associated with undesirable side effects. As a result, the development of a novel active, safe anti-hyperuricaemic and anti-inflammatory medicine could be extremely beneficial in gout treatment. Natural products have become a source of new medications because of their high efficacy and low side effects, which are based on the presence of complex bioactive components. A rising number of researchers document that traditional medications can reduce serum urate levels. This article is intended to trace which herbal remedies could alleviate hyperuricemia, as well as their mechanism of actions. Graphical abstract

Burden and impact of periodontal diseases on oral health-related quality of life and systemic diseases and conditions: Latin America and the Caribbean Consensus 2024

Brazilian oral research · 2024

📚 7 citations🎯 RCR 2.42Top 21% NIH🔓 Open Access📄 PDF gratuit ↗

Discovery of novel TACE inhibitors using graph convolutional network, molecular docking, molecular dynamics simulation, and Biological evaluation

PloS one · 2024

📚 5 citations🎯 RCR 1.49🔓 Open Access

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The increasing utilization of deep learning models in drug repositioning has proven to be highly efficient and effective. In this study, we employed an integrated deep-learning model followed by traditional drug screening approach to screen a library of FDA-approved drugs, aiming to identify novel inhibitors targeting the TNF-α converting enzyme (TACE). TACE, also known as ADAM17, plays a crucial role in the inflammatory response by converting pro-TNF-α to its active soluble form and cleaving other inflammatory mediators, making it a promising target for therapeutic intervention in diseases such as rheumatoid arthritis. Reference datasets containing active and decoy compounds specific to TACE were obtained from the DUD-E database. Using RDKit, a cheminformatics toolkit, we extracted molecular features from these compounds. We applied the GraphConvMol model within the DeepChem framework, which utilizes graph convolutional networks, to build a predictive model based on the DUD-E datasets. Our trained model was subsequently used to predict the TACE inhibitory potential of FDA-approved drugs. From these predictions, Vorinostat was identified as a potential TACE inhibitor. Moreover, molecular docking and molecular dynamics simulation were conducted to validate these findings, using BMS-561392 as a reference TACE inhibitor. Vorinostat, originally an FDA-approved drug for cancer treatment, exhibited strong binding interactions with key TACE residues, suggesting its repurposing potential. Biological evaluation with RAW 264.7 cell confirmed the computational results, demonstrating that Vorinostat exhibited comparable inhibitory activity against TACE. In conclusion, our study highlights the capability of deep learning models to enhance virtual screening efforts in drug discovery, efficiently identifying potential candidates for specific targets such as TACE. Vorinostat, as a newly identified TACE inhibitor, holds promise for further exploration and investigation in the treatment of inflammatory diseases like rheumatoid arthritis.

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M MAX HASSAN

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal21

Case report / série5

Lupus5

Arthrite juvénile2

Génétique2

JAK inhibiteurs2

Recommandations2

Revue générale2

Biomarqueurs / Auto-Ac1

Biothérapies non-anti-TNF1

Corticothérapie1

csDMARDs1

Économie santé1

Épidémiologie & registres1

Essai clinique1

Pédiatrie1

Pharmacovigilance1

Qualité de vie / PROMs1

Revue / méta-analyse1

SAPL1

Spondyloarthrite1

Vraie vie / RWE1

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