Mme Docteur LAURENCE FERRIERES

Bibliographie

• The serum levels of FGF23, sclerostin, osteoprotegerin do not explain the inverse relationship between coronary calcifications and bone mineral density evaluated using computed tomography

  2025

  ArticleFrontiers in Cardiovascular Medicine

• No impact of anti-Rank ligand and PTH analogs on cardiovascular risk in postmenopausal osteoporosis: a systematic literature review and meta-analysis

  2020

  ArticleArchives of Osteoporosis

• Whipple’s disease: diagnosis and predictive factors of relapse

  2020

  ArticleEuropean Journal of Gastroenterology & Hepatology

• High-power tunable low-noise coherent source at 1.06µm based on a surface-emitting semiconductor laser

  2018

  ArticleApplied optics

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

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Top publications · les plus citées

• 1

  No impact of anti-Rank ligand and PTH analogs on cardiovascular risk in postmenopausal osteoporosis: a systematic literature review and meta-analysis

  Archives of osteoporosis · 2020

  📚 13 citations
• 2

  Whipple's disease: diagnosis and predictive factors of relapse

  European journal of gastroenterology & hepatology · 2020

  📚 5 citations

  Lire l'abstract Crossref ↓

  Background Whipple’s disease is a very rare disease needing a long-term treatment. The most frequent symptoms are recurrent arthralgia or arthritis, chronic diarrhea, abdominal pain, and weight loss. Objectives In this article, we have highlighted the main clinical features and diagnostic procedures that lead to the diagnosis and comment on the clinical response, treatment, and the factors of relapse. Methods Subjects were recruited from the Internal Medicine and Rheumatologic Departments of an University Hospital from November 1997 to January 2016. Overall, 12 subjects were finally diagnosed. Results Mean age was 54.3 years (age range: 30–81), with more male patients (58.3%). Almost all patients had articular symptoms and impaired general condition (91.7%); and a majority had digestive symptoms (75%). Regardless of the symptoms, the most efficient diagnostic tools were the PCR screening on the gastrointestinal biopsies and saliva (83.3 and 72.7% positive results, respectively). More than half of the patients relapsed (55.6%). The relapsing patients were older [63.2 (44–81)] and mostly male with a majority (60%) of digestive symptoms and a delayed diagnosis. Conclusions In current practice, it is highly difficult to diagnose Whipple’s disease. In order to decrease the delay between the first symptoms and the diagnosis, effective tools such as saliva and stools PCR should be used because higher delays of diagnosis lead to a higher number of relapses.

• 3

  The serum levels of FGF23, sclerostin, osteoprotegerin do not explain the inverse relationship between coronary calcifications and bone mineral density evaluated using computed tomography

  Frontiers in cardiovascular medicine · 2025

  📚 1 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  BackgroundOsteoporotic patients are at a higher risk of stroke or myocardial infarction compared to non-osteoporotic patients, and conversely, individuals who have experienced a myocardial infarction or stroke are at increased risk for low bone mineral density (BMD) or osteoporotic fractures. Some studies suggest that the relationship between osteoporosis and vascular calcification may stem from the dysregulation of common factors that are implicated in both bone remodeling and the formation of calcified vascular plaques.ObjectivesOur primary endpoint was to evaluate the correlation between bone mineral density and calcification score. Our secondary endpoint was to analyse the association between potential shared serum biomarkers and the calcification score or bone status.MethodsWe conducted a retrospective study between May and October 2015 in 94 patients who had undergone a thoracic CT scan, to assess their coronary risk by calculating an Agatston score. The scans were re-analysed to obtain volumetric bone mineral densities (vBMD). We measured osteoprotegerin, FGF23 and sclerostin in frozen serums from these patients.ResultsPatients with a calcium score of 0 had a significantly higher vBMD than patients with a calcium score > 0 (187.7 vs. 162.1, p 0.03). This relationship persisted after adjusting for age, sex, BMI and sedentarity (p 0.036). There was no significant relationship between FGF23, osteoprotegerin, or sclerostin levels and the calcium score or vBMD.ConclusionLower vertebral thoracic bone mineral density is significantly associated with an increased risk of vascular calcification. However, this relationship is not explained by the serum levels of FGF23, sclerostin, or osteoprotegerin.

Publications scientifiques (4) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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