Docteur PAUL ARNOLFO

Bibliographie

• Pyomyositis of the obturator internus muscle

  2025

  ArticleJoint Bone Spine

• Musculoskeletal disorders affecting upper and lower limbs in pregnant women: How to manage them?

  2025

  ArticleRevue du Rhumatisme

• Neuralgic amyotrophy of Parsonage and Turner in daily practice: More often mononeuropathic than previously assumed

  2025

  ArticleJoint Bone Spine

• Hemiplegic shoulder pain, a combined approach with suprascapular nerve block and intra-articular corticosteroid injections: a case series

  2025

  ArticleFrontiers in Neurology

• Update on contribution of hip labral tears to hip pain: A narrative review

  2023

  ArticleJoint Bone Spine

• Inadequacies of the Lasègue test, and how the Slump and Bowstring tests are useful for the diagnosis of sciatica

  2021

  ArticleJoint Bone Spine

• Insuffisances du signe de Lasègue, et intérêt du signe de Slump et du signe de la corde de l’arc pour le diagnostic positif des sciatiques radiculaires

  2020

  ArticleRevue du Rhumatisme

• Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

  2020

  ArticleArthritis Research & Therapy

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

• CHU DE NANTES SITE HOTEL DIEU HME

  1 Place ALEXIS RICORDEAU, 44093 Nantes

  ☎ 0240087323Hospitalier🏥 Centre CHU ↗🏥 Voir cet établissement

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (1)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• Spécial hôpitaux - Mal de dos : la prescription nantaise - Le Point

  📰 Le Point · 26/08/2016

  <a href="https://news.google.com/rss/articles/CBMiuwFBVV95cUxOZG9BZjBGelZPelAwSDlTUGpLcHdrM3BPMHBkek5INlV1ajBsYllJMWJ5alhxaE0xVjJNZVNjemdZWF9iNzhnTFVkbnR3VkRUU0RlSTZYUlBDRW9LMEFGLTdRNndwWVlwUHJ2ajEwUzNSZWdrYUkzUTNfWGFfdi0zOUxwWDNuVmRFNXBBdktFS1lkMzh6LUdkdTBoc2FGOU9wNnI3WHV6TDZpTktsTU9SUUpMdzBRNWg5Uk

Top publications · les plus citées

• 1

  Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner

  Journal of clinical medicine · 2019

  📚 16 citations🎯 RCR 1.07🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Calcific tendonitis is a frequent cause of chronic shoulder pain. Its cause is currently poorly known. The objectives of this study were to better characterize the cells and mechanisms involved in depositing apatite crystals in human tendons. Histologic sections of cadaveric calcified tendons were analyzed, and human calcific deposits from patients undergoing lavage of their calcification were obtained to perform infrared spectroscopy and mass spectrometry-based proteomic characterizations. In vitro, the mineralization ability of human rotator cuff cells from osteoarthritis donors was assessed by alizarin red or Von Kossa staining. Calcifications were amorphous areas surrounded by a fibrocartilaginous metaplasia containing hypertrophic chondrocyte-like cells that expressed tissue non-specific alkaline phosphatase (TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which are two key enzymes of the mineralization process. Calcific deposits were composed of apatite crystals associated with proteins involved in bone and cartilage development and endochondral bone growth. In vitro, tenocyte-like cells extracted from the rotator cuff were able to mineralize in osteogenic cultures, and expressed TNAP, type X COLLAGEN, and MMP13, which are hypertrophic chondrocytes markers. The use of a TNAP inhibitor significantly prevented mineral deposits. We provide evidence that tenocytes have a propensity to differentiate into hypertrophic chondrocyte-like cells to produce TNAP-dependent calcium deposits. We believe that these results may pave the way to identifying regulating factors that might represent valuable targets in calcific tendonitis.

• 2

  Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

  Arthritis research & therapy · 2020

  📚 12 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract Background Excessive bone formation in the entheses is one of the features of peripheral spondyloarthritis (SpA). Complex pathological mechanisms connecting inflammation, mechanical stress, and ossification are probably involved. We focused on bone morphogenetic protein (BMP)-2, -4, and -7 as possible mediators of this process. Methods BMP-2, -4, and -7 concentration was measured by ELISA in synovial fluids (SFs) of SpA (n = 56) and osteoarthritic (n = 21) patients. Mouse organotypic ankle cultures were challenged by a pro-inflammatory cocktail. Mouse primary chondrocytes, osteoblasts, or tenocytes were treated with TNF-α, interleukin (IL)-17, or IL-22 and/or subjected to cyclic stretch, or with recombinant BMP-2 or -4. Results In SpA SFs, if BMP-7 was barely detectable, BMP-2 concentration was higher and BMP-4 was lower than in osteoarthritic samples, so that BMP-2/BMP-4 ratio augmented 6.5 folds (p &lt; 0.001). In SpA patients, TNF-α, IL-6, and IL-17 levels correlated this ratio (n = 21). Bmp-2/Bmp-4 ratio was similarly enhanced by cytokine treatment in explant and cell cultures, at mRNA level. In particular, simultaneous application of TNF-α and cyclical stretch induced a 30-fold increase of the Bmp-2/Bmp-4 ratio in chondrocytes (p = 0.027). Blockade of prostaglandin E2 and IL-6 production had almost no effect on the stretch-induced regulation of Bmp-2 or -4. Osteoinductive effects of BMP-4, and to a lesser extend BMP-2, were identified on cultured chondrocytes and tenocytes. Conclusions Our results first settle that BMP factors are locally deregulated in the SpA joint. An unexpected decrease in BMP-4 could be associated to an increase in BMP-2, possibly in response to mechanical and/or cytokine stimulations.

• 3

  Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis

  Clinical case reports · 2022

  📚 9 citations🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract This 38‐year‐old man has a familial BRCA2 mutation. He presented with skin erythema, polyarthritis, dactylitis, and febrile erythema nodosum; a biopsy of a liver metastase revealed acinar cell carcinoma of the pancreas. After FOLFIRINOX, olaparib was initiated, and 24 months after, the patient was PS 0 and asymptomatic.

Publications scientifiques (8) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• Additional file 2 of Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

  Image2020figshare

  Additional file 2: Supplementary figure 2. Connection between IL-6 and PGE2 inflammation pathways and the TNF-α stimulation. TNF-α-treated cultured chondrocytes (10 ng/mL, 24 h) were compared to control cells. (A) Gene e

• Additional file 3 of Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

  Image2020figshare

  Additional file 3: Supplementary figure 3. Comparison of the steady-state level of some osteogenic and chondrogenic markers between cultured osteoblasts, chondrocytes and tenocytes. (A) Bglap2, Alpl, Col1a1 and Col2a1 re

• Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

  Collection2020figshare

  Abstract Background Excessive bone formation in the entheses is one of the features of peripheral spondyloarthritis (SpA). Complex pathological mechanisms connecting inflammation, mechanical stress, and ossification are

• Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

  Collection2020figshare

  Abstract Background Excessive bone formation in the entheses is one of the features of peripheral spondyloarthritis (SpA). Complex pathological mechanisms connecting inflammation, mechanical stress, and ossification are

• Additional file 2 of Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

  Image2020figshare

  Additional file 2: Supplementary figure 2. Connection between IL-6 and PGE2 inflammation pathways and the TNF-α stimulation. TNF-α-treated cultured chondrocytes (10 ng/mL, 24 h) were compared to control cells. (A) Gene e

• Additional file 3 of Enhanced BMP-2/BMP-4 ratio in patients with peripheral spondyloarthritis and in cytokine- and stretch-stimulated mouse chondrocytes

  Image2020figshare

  Additional file 3: Supplementary figure 3. Comparison of the steady-state level of some osteogenic and chondrogenic markers between cultured osteoblasts, chondrocytes and tenocytes. (A) Bglap2, Alpl, Col1a1 and Col2a1 re

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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