📇 Rhumatologue · NANCY CEDEX · (54) · Hospitalier

M FRANCOIS ZHU

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Auteur de référence en rhumatologie
25 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
146.3 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 NANCY CEDEX (54)HospitalierRPPS 10101748761

Publications actives

2ans d'exercice (thèse 2024)·56 publications sur 5 ans

📊 Reconnaissance scientifique : 24/100📝 118 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg

European journal of nutrition · 2024

📚 13 citations🎯 RCR 2.73Top 18% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Background Postmenopausal osteoporosis (PMO) is a chronic condition characterized by decreased bone strength. This study aims to investigate the effects and mechanisms of the combination of Butyricicoccus pullicaecorum (Bp) and 3-hydroxyanthranilic acid (3-HAA) on PMO. Methods The effects of Bp and 3-HAA on PMO were evaluated in ovariectomized (OVX) rats by assessing stereological parameters, femur microstructure, and autophagy levels. The T helper (Th) 17/Regulatory T (Treg) cells of rats were detected using flow cytometric analysis. Furthermore, the impact of Bp and 3-HAA on the gut microbiota of rats was assessed using 16S rRNA gene sequencing. The correlation between the gut microbiota of rats and Th17/Treg immune factors, as well as femoral stereo parameters, was separately assessed using Spearman rank correlation analysis. Results Bp and 3-HAA treatments protected OVX rats by promoting osteogenesis and inhibiting autophagy. Compared to the Sham group, OVX rats showed an increase in Th17 cells and a decrease in Treg cells. Bp and 3-HAA reversed these changes. Enterorhabdus and Pseudomonas were significantly enriched in OVX rats. Bp and 3-HAA regulated the gut microbiota of OVX rats, enriching pathways related to nutrient metabolism and immune function. There was a correlation between the gut microbiota and the Th17/Treg, as well as femoral stereo parameters. The concurrent administration of Bp and 3-HAA medication facilitated the enrichment of gut microbiota associated with the improvement of PMO. Conclusion The combination therapy of Bp and 3-HAA can prevent PMO by modulating the gut microbiota and restoring Th17/Treg immune homeostasis.

Analysis of the relationships between interferon-stimulated genes and anti-SSA/Ro 60 antibodies in primary Sjögren's syndrome patients via multiomics and machine learning methods

International immunopharmacology · 2025

📚 3 citations

Safety and efficacy of direct versus conventional transfer to angiography suite in patients with severe acute stroke treated with thrombectomy (DIRECT ANGIO) in France: a multicentre, open-label, blinded-endpoint, randomised controlled trial

The Lancet. Neurology · 2026

📚 1 citations🩺 Clinique🔓 Open Access

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M FRANCOIS ZHU

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Thèses universitaires

Activité de recherche & publications

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (25) — classées par pathologie

Transversal12

Goutte3

IA en rhumatologie2

Pharmacovigilance2

Essai clinique1

Gériatrie1

Lupus1

Microbiote1

Ostéoporose1

Pédiatrie1

SAPL1

Sjögren1

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