📇 Rhumatologue · BOURGES CEDEX · (18) · Salarié

M PATRICK VINCENT

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3 raisons identifiées

Praticien-chercheur
15 articles scientifiques publiés — formation continue solide
Expérience confirmée
34 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
73 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 BOURGES CEDEX (18)SalariéRPPS 10001984573

Expérience confirmée

34ans d'exercice (thèse 1992)

📊 Reconnaissance scientifique : 29/100📝 130 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Thèses universitaires

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

A metamaterial for directive emission

Physical review letters · 2002

📚 186 citations🎯 RCR 4.89Top 8% NIH

Evaluation of 16S rRNA gene PCR sensitivity and specificity for diagnosis of prosthetic joint infection: a prospective multicenter cross-sectional study

Journal of clinical microbiology · 2014

📚 140 citations🎯 RCR 7.21Top 4% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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ABSTRACT There is no standard method for the diagnosis of prosthetic joint infection (PJI). The contribution of 16S rRNA gene PCR sequencing on a routine basis remains to be defined. We performed a prospective multicenter study to assess the contributions of 16S rRNA gene assays in PJI diagnosis. Over a 2-year period, all patients suspected to have PJIs and a few uninfected patients undergoing primary arthroplasty (control group) were included. Five perioperative samples per patient were collected for culture and 16S rRNA gene PCR sequencing and one for histological examination. Three multicenter quality control assays were performed with both DNA extracts and crushed samples. The diagnosis of PJI was based on clinical, bacteriological, and histological criteria, according to Infectious Diseases Society of America guidelines. A molecular diagnosis was modeled on the bacteriological criterion (≥1 positive sample for strict pathogens and ≥2 for commensal skin flora). Molecular data were analyzed according to the diagnosis of PJI. Between December 2010 and March 2012, 264 suspected cases of PJI and 35 control cases were included. PJI was confirmed in 215/264 suspected cases, 192 (89%) with a bacteriological criterion. The PJIs were monomicrobial (163 cases [85%]; staphylococci, n = 108; streptococci, n = 22; Gram-negative bacilli, n = 16; anaerobes, n = 13; others, n = 4) or polymicrobial (29 cases [15%]). The molecular diagnosis was positive in 151/215 confirmed cases of PJI (143 cases with bacteriological PJI documentation and 8 treated cases without bacteriological documentation) and in 2/49 cases without confirmed PJI (sensitivity, 73.3%; specificity, 95.5%). The 16S rRNA gene PCR assay showed a lack of sensitivity in the diagnosis of PJI on a multicenter routine basis.

The mechanism of neutropenia in Felty's syndrome

British journal of haematology · 1974

📚 82 citations🎯 RCR 3.58

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Summary. Neutrophil kinetics were studied in 17 patients with Felty's syndrome using an in vitro diisopropylfluorophosphate‐32P technique. Excessive margination of neutrophils was present in all patients, and was solely responsible for the neutro‐penia in 12. Five patients had a total blood neutrophil pool which was so low that they would have been neutropenic even with a normal ratio of marginated to circulating cells; in these the production rate was subnormal. In no case was neutropenia due to shortened nueutrophil survival. There was no correlation between either the degree of marrow cellularity, or serum lysozyme levels, and the measured neutrophil production rate. Two patients studied before and after splenectomy showed improvement in kinetic abnormalities following operation. We conclude that the principal mechanism responsible for the neutropenia in Felty's syndronie is excessive margination of cells. In about one third of patients neutrophil production is subnormal in addition, but excessive neutrophil destruction is an uncommon finding. Conventional laboratory investigations are of little or no help in defining the mechanism in an individual patient. The value of splenectomy still has to be established, although short‐term improvement in kinetic parameters may occur.

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M PATRICK VINCENT

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Thèses universitaires

Activité de recherche & publications

Publications académiques en France

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Publications scientifiques (15) — classées par pathologie

Transversal5

Essai clinique4

Case report / série1

Économie santé1

Lupus1

Pédiatrie1

Revue / méta-analyse1

Revue générale1

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