Docteur Félicie VERDIER
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Lieu de consultation
CH LES FEUGRAIS CHI ELBEUF
76503 Elbeuf
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Ruk is ubiquitinated but not degraded by the proteasome
European journal of biochemistry · 2002
Lire l'abstract Crossref ↓
The regulator of ubiquitous kinase (Ruk) protein, also known as CIN85 or SETA, is an adaptor‐type protein belonging to the CD2AP/CMS family. It was found in complexes with many signaling proteins, including phosphoinositol (PtdIns) 3‐kinase (EC 2.7.1.137), Cbl, GRB2, p130Cas and Crk. Functional analysis of these interactions, implicated Ruk in the regulation of apoptosis, receptor endocytosis and cytoskeletal rearrangements. We have recently demonstrated that overexpression of Ruk induces apoptotic death in neurons, which could be reversed by activated forms of PtdIns 3‐kinase and PKB/Akt. Furthermore, Ruk was shown to be a negative regulator of PtdIns 3‐kinase activity through binding to its P85 regulatory subunit [Gout, I., Middleton, G., Adu, J., Ninkina, N. N., Drobot, L. B., Filonenko, V., Matsuka, G., Davies, A.M., Waterfield, M. & Buchman, V. L. (2000) Embo J.19, 4015–4025]. Here, we report for the first time, that all three isoforms of Ruk (L, M and S) are ubiquitinated. Specific interaction between the E3 ubiquitin ligase Cbl and all three Ruk isoforms was demonstrated by coexpression studies in Hek293 cells. The interaction of Ruk M and S isoforms with Cbl was found to be mediated via heterodimerization with Ruk L. The use of proteosomal and lysosomal inhibitors clearly indicated that ubiquitination of Ruk L does not lead to its degradation. Based on this study, we propose a possible mechanism for the regulation of Ruk function by ubiquitination.
- 2Popliteal lymph node response to procainamide and isoniazid. Role of beta-naphthoflavone, phenobarbitone and S9-mix pretreatment
Toxicology letters · 1993
📚 15 citations - 3
Publications scientifiques (6) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal6
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Transversal6
▼- [Outcome of 30 congenital atrio-ventricular blocks]
Archives des maladies du coeur et des vaisseaux · 2005 · English Abstract
Verdier F, Jimenez M, Chevalier JM, Thambo JB, et al.
- Lack of induction of autoantibody responses following immunization with cytomegalovirus (CMV) glycoprotein B (gB) in healthy CMV-seronegative subjects
Vaccine · 2004 · Clinical Trial
Schleiss MR, Bernstein DI, Passo M, Parker S, et al.
📚 9 cit.🩺 Clinique - Ruk is ubiquitinated but not degraded by the proteasome
European journal of biochemistry · 2002 · Comparative Study
Verdier F, Valovka T, Zhyvoloup A, Drobot LB, et al.
📚 19 cit. - The popliteal lymph node assay in 1996
Toxicology · 1997 · Journal Article
Descotes J, Patriarca C, Vial T, Verdier F
📚 12 cit. - Popliteal lymph node response to procainamide and isoniazid. Role of beta-naphthoflavone, phenobarbitone and S9-mix pretreatment
Toxicology letters · 1993 · Comparative Study
Patriarca C, Verdier F, Brouland JP, Descotes J
📚 15 cit. - Popliteal lymph node assay as a tool to predict drug-induced GvH-like reactions
Developments in biological standardization · 1992 · Journal Article
Descotes J, Verdier F, Brouland JP, Patriarca C
📚 1 cit.