📇 Rhumatologue · ST NAZAIRE CEDEX · (44) · Salarié
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1 raison identifiée
Délais de RDV courts dans la région
129.9 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CH DE SAINT NAZAIRE
CITE SANITAIRE GEORGES CHARPAK 11 BD GEORGES CHARPAK BP 414, 44606 ST NAZAIRE CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2002
AbstractMechanical loading of articular cartilage can produce catabolic and anabolic changes in tissue metabolism. Most previous studies in this area have focussed on aggrecan. Little information concerning load‐induced collagen modifications has been obtained. We have therefore conducted studies where mechanical loads are applied in vitro to full thickness cartilage explants retaining a thin layer of bone, in order to investigate mechanically induced collagen breakdown and consequent turnover, in addition to aggrecan changes and mechanical property alterations. Tissue explant disks were subjected to unconfined compression and either immediately frozen or kept in static culture for 10 days. Mechanical tests of the disks immediately prior to and just after the cyclic loading period were also performed. They showed a weakening of the collagen network and an increased hydraulic permeability due to the cyclic loading. Load‐induced alterations of the extracellular matrix was then clearly evidenced by an increase in denatured collagen in the disks frozen immediately after loading compared to unloaded controls. Loaded disks maintained in culture for 10 additional days following cyclic loading no longer expressed this increase in denatured collagen suggesting that mechanically denatured collagen II had undergone a removal process which could represent turnover or repair, or the beginning of progressive degradation. Indeed matrix fragments of collagen II and glycosaminoglycans were found to be released to post‐loading culture medium in increased quantities compared to unloaded controls. Our data further demonstrates the ability of mechanical load of articular cartilage to modulate turnover and metabolism of collagen and proteoglycan in a complex and multifactorial manner that may be of particular significance in the pathogenesis of osteoarthritis and in the development of pharmacological agents to modulate its progression.© 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
Resuscitation · 2024
Joint bone spine · 2009
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Resuscitation · 2024 · Journal Article
Javaudin F, Papin M, Le Bastard Q, Thibault M, et al.
Joint bone spine · 2009 · Letter
Ottaviani S, Kemiche F, Thibault M, Cerf-Payrastre I, et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2002 · Journal Article
Thibault M, Poole AR, Buschmann MD