📇 Rhumatologue · TARBES · (65) · Salarié
Chargement de la fiche…
Chargement de la fiche…
MonRhumato.fr utilise des cookies pour mesurer l'audience (statistiques) et améliorer le site. Aucune donnée de santé identifiable n'est jamais collectée. Politique de confidentialité.
Votre choix est conservé 13 mois (durée max CNIL). Vous pouvez le modifier à tout moment via Préférences cookies.
2 raisons identifiées
Auteur de référence en rhumatologie
46 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
122.6 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CDS MUNICIPAL LOUIS LARENG
45 PL DU FOIRAIL, 65000 TARBES
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018
Climacteric : the journal of the International Menopause Society · 2020
Arthritis & rheumatology (Hoboken, N.J.) · 2024
ObjectiveFibroblast‐like synoviocytes (FLSs) contribute to inflammation and joint damage in rheumatoid arthritis (RA). However, the regulatory mechanisms of FLSs in relapse and remission of RA remain unknown. Identifying FLS heterogeneity and their underlying pathogenic roles may lead to discovering novel disease‐modifying antirheumatic drugs.MethodsCombining single‐cell RNA sequencing (scRNA‐seq) and spatial transcriptomics, we sequenced six matched synovial tissue samples from three patients with relapse RA and three patients in remission. We analyzed the differences in the transcriptomes of the FLS subsets between the relapse and remitted phases. We validated several key signaling pathways using quantitative real‐time PCR (qPCR) and multiplex immunohistochemistry (mIHC). We further targeted the critical signals in vitro and in vivo using the collagen‐induced arthritis (CIA) model in rats.ResultsLining and sublining FLS subsets were identified using scRNA‐seq. Differential analyses indicated that the fibroblast growth factor (FGF) pathway was highly activated in the lining FLSs from patients with relapse RA for which mIHC confirmed the increased expression of FGF10. Although the type I interferon pathway was also activated in the lining FLSs, in vitro stimulation experiment suggested that it was independent of the FGF10 pathway. FGF10 knockdown by small interfering RNA in FLSs significantly reduced the expression of receptor activator of NF‐κB ligand. Moreover, recombinant FGF10 protein enhanced bone erosion in the primary human‐derived pannus cell culture, whereas the FGF receptor (FGFR) 1 inhibitor attenuated this process. Finally, administering an FGFR1 inhibitor displayed a therapeutic effect in a CIA rat model.ConclusionThe FGF pathway is a critical signaling pathway in relapse RA. Targeted tissue‐specific inhibition of FGF10/FGFR1 may provide new opportunities to treat patients with relapse RA.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Frontiers in immunology · 2026 · Published Erratum
Zheng L, A X, Ma S, Xu B, et al.
Frontiers in immunology · 2026 · Journal Article
A X, Xin P, Zheng L, Xu B, et al.
Frontiers in immunology · 2026 · Published Erratum
Zheng L, A X, Ma S, Xu B, et al.
Frontiers in immunology · 2025 · Journal Article
Zheng L, A X, Ma S, Xu B, et al.
Chinese medicine · 2025 · Journal Article
Bian Y, Li F, A X, Xiang Z, et al.
Frontiers in immunology · 2025 · Journal Article
A X, Xin P, Zheng L, Xu B, et al.
Scientific reports · 2025 · Journal Article
M C S, B K, A U, K C S
BMC veterinary research · 2025 · Journal Article
A S, S AP, J M, P C, et al.
Cureus · 2025 · Journal Article
N M, A NT, Muruganandan R, Vellingiri K
European journal of pharmacology · 2025 · Journal Article
N P, M M G, C RR, D P, et al.
Arthritis & rheumatology (Hoboken, N.J.) · 2024 · Journal Article
Meng X, Chen Z, Li T, Nie Z, et al.
Biomacromolecules · 2024 · Journal Article
Kabir A, B M, A N, Selvaraj V, et al.
Journal of autoimmunity · 2024 · Journal Article
Martin CS, Crastin A, Sagmeister MS, Kalirai MS, et al.
Brain research bulletin · 2024 · Journal Article
Kang B, Ma J, Shen J, Zhao C, et al.
Journal of biomolecular structure & dynamics · 2024 · Journal Article
Kannan P, A HB, N MP, D TK, et al.
Case reports in rheumatology · 2024 · Case Reports
Wang S, A A, Feinstein D, Traisak P, et al.
Zhonghua yi xue za zhi · 2023 · English Abstract
Lyu YK, Li ZA, A XR, Ma JD, et al.
American journal of translational research · 2023 · Journal Article
A R, Mu R, Wu Q, Ga L, et al.
Journal of clinical medicine · 2021 · Journal Article
A G, Yano S, Sheik AM, Yu A, et al.
Osteoarthritis and cartilage open · 2021 · Journal Article
A D, A T, T J, O R, et al.
Journal of biomedical physics & engineering · 2020 · Journal Article
A A, R N, G C
Climacteric : the journal of the International Menopause Society · 2020 · Journal Article
Luo Y, Ma Y, Qiao X, Zeng R, et al.
Prostaglandins & other lipid mediators · 2018 · Journal Article
G S, G L S, Pushpan CK, Nambisan B, et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017 · Journal Article
Mathew LE, Rajagopal V, A H
Journal of orthopaedic case reports · 2016 · Case Reports
R M, D VV, A LG, P G, et al.
The open orthopaedics journal · 2015 · Journal Article
H N, A P S, S B, A U, et al.
The open rheumatology journal · 2014 · Journal Article
F E A, N K, H A, F L, et al.
European journal of pharmacology · 2013 · Journal Article
Ma B, Li X, Zhang Q, Wu D, et al.
PloS one · 2013 · Journal Article
Ma B, Liu J, Zhang Q, Ying H, et al.
Rheumatology international · 2012 · Journal Article
Leonel D, Lucia C, A M, Martha-Alicia H, et al.
The open orthopaedics journal · 2012 · Journal Article
M M, H G, S H, A J, et al.
Zhonghua yi xue za zhi · 2011 · Comparative Study
Zeng Y, Cao L, Liu Y, Peng GF, et al.
International journal of biomedical science : IJBS · 2007 · Journal Article
A Z, Cd K, Ad V, T K, et al.
Archives of osteoporosis · 2025 · Journal Article
N BV, A MS, A DR, H SG, et al.
Journal of bone and mineral metabolism · 2023 · Journal Article
Anna G, Anne-Lise F, Clémence D, Jean-Michel P, et al.
Cureus · 2025 · Journal Article
Muraleedharan A, Chaubey S, A S, Yadav A
Revue de l'infirmiere · 2016 · English Abstract
A M
Clinical rheumatology · 2025 · Journal Article
A K, M EA, M H, H A, et al.
Arthritis & rheumatology (Hoboken, N.J.) · 2026 · Journal Article
Xin P, Li W, A X, Shen J, et al.
Cureus · 2024 · Case Reports
Ravichandran S, Kumar J, Chandrasekaran ND, Irfan S, et al.
Frontiers in pharmacology · 2023 · Journal Article
Ran L, Xu B, Han HH, Wang JY, et al.
JMIR research protocols · 2025 · Journal Article
M A, Ahmad A, A A, Raj LS, et al.
Pain medicine (Malden, Mass.) · 2023 · Randomized Controlled Trial
Xu H, Zhao C, Guo G, Li Y, et al.
Brain and behavior · 2022 · Journal Article
Kang BX, Ma J, Shen J, Xu H, et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2018 · Journal Article
Cao W, Qian G, Luo W, Liu X, et al.
Indian pediatrics · 2005 · Case Reports
A SE, Moses PD, George R
Pain medicine (Malden, Mass.) · 2023 · Randomized Controlled Trial
Xu H, Zhao C, Guo G, Li Y, et al.