📇 Rhumatologue · LE KREMLIN BICETRE CEDEX · (94) · Hospitalier

M LAURENT SAVALE

Pourquoi vous devez consulter ce praticien

5 raisons identifiées

Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
30 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (4 thèses dirigées)
Expérience confirmée
16 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
134 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LE KREMLIN BICETRE CEDEX (94)HospitalierRPPS 10001630630

EnseignementExpérience confirmée

16ans d'exercice (thèse 2010)

📊 Reconnaissance scientifique : 69/100📝 551 articles publiés🇫🇷 Publications académiques françaises (8)🎓 4 thèses dirigées

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death

The New England journal of medicine · 2025

📚 69 citations🎯 RCR 28.08🩺 Clinique

Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome

American journal of respiratory and critical care medicine · 2024

📚 22 citations🎯 RCR 4.85Top 8% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract Rationale Hepatopulmonary syndrome (HPS) is a severe complication of liver diseases characterized by abnormal dilation of pulmonary vessels, resulting in impaired oxygenation. Recent research highlights the pivotal role of liver-produced BMP-9 (bone morphogenetic protein-9) in maintaining pulmonary vascular integrity. Objectives This study aimed to investigate the involvement of BMP-9 in human and experimental HPS. Methods Circulating BMP-9 levels were measured in 63 healthy control subjects and 203 patients with cirrhosis with or without HPS. Two animal models of portal hypertension were employed: common bile duct ligation with cirrhosis and long-term partial portal vein ligation without cirrhosis. Additionally, the therapeutic effect of low-dose BMP activator FK506 was investigated, and the pulmonary vascular phenotype of BMP-9–knockout rats was analyzed. Measurements and Main Results Patients with HPS related to compensated cirrhosis exhibited lower levels of circulating BMP-9 compared with patients without HPS. Patients with severe cirrhosis exhibited consistently low levels of BMP-9. HPS characteristics were observed in animal models, including intrapulmonary vascular dilations and an increase in the alveolar-arterial gradient. HPS development in both rat models correlated with reduced intrahepatic BMP-9 expression, decreased circulating BMP-9 level and activity, and impaired pulmonary BMP-9 endothelial pathway. Daily treatment with FK506 for 2 weeks restored the BMP pathway in the lungs, alleviating intrapulmonary vascular dilations and improving gas exchange impairment. Furthermore, BMP-9–knockout rats displayed a pulmonary HPS phenotype, supporting its role in disease progression. Conclusions The study findings suggest that portal hypertension–induced loss of BMP-9 signaling contributes to HPS development.

Severe Hypoxemia and Pulmonary Capillary Dilatations in Pulmonary Arterial Hypertension Patients Treated with Sotatercept

American journal of respiratory and critical care medicine · 2025

📚 12 citations🎯 RCR 4.56

Cookies & analyse de trafic

M LAURENT SAVALE

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Direction de thèses

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (30) — classées par pathologie

Transversal20

Épidémiologie & registres2

Recommandations2

Biomarqueurs / Auto-Ac1

Case report / série1

Essai clinique1

Génétique1

IRM ostéo-articulaire1

Revue / méta-analyse1

Revue générale1

Santé mentale / fatigue1

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