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5 raisons identifiées
Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Auteur de référence en rhumatologie
30 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (4 thèses dirigées)
Expérience confirmée
16 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
134 rhumatos / 100 000 hab. — département bien doté
16ans d'exercice (thèse 2010)
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
✨ Génération du profil synthétique IA en cours…
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Traitements de l'hypertension pulmonaire : Optimisation et Innovation Thérapeutique
2026Doctorant·e : Antoine Le Bozec
Étude du BMP-9 et du PlGF dans la physiopathologie du syndrome hépatopulmonaire : À la recherche de cibles thérapeutiques
2024Doctorant·e : Fabien Robert
Marqueurs pronostiques et stratification du risque dans l’HTAP
2021Doctorant·e : Athénaïs Boucly
Transplantation pulmonaire et cardio-pulmonaire dans l'hypertension pulmonaire : État des lieux et perspectives d'optimisation
Doctorant·e : Pauline Pradère
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
69
69 articles ont été cités au moins 69fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
17 198
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
551
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
191
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Inserm · Inserm · Université Paris-Saclay
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Benefit and risk associated with interleukin-6 receptor inhibitor administration during severe COVID-19: a retrospective multicentric study
2026ArticleScientific Reports
Pulmonary hypertension in patients with Noonan syndrome
2025ArticleEuropean Respiratory Journal
Evolving paradigms in pulmonary hypertension: Highlights of the 6th French Pulmonary Hypertension Network Meeting
2025ArticleRespiratory Medicine and Research
Cardiopulmonary Hemodynamic Determinants of Long-Term Survival in Sickle Cell Disease: Insights from the ETENDARD Study
2025ArticleAmerican Journal of Respiratory and Critical Care Medicine
Sickle Cell Diastolic Cardiomyopathy and Mortality Risk: A Novel Echocardiographic Framework for Prognostic Stratification
2025ArticleAmerican Journal of Hematology
Bone Morphogenetic Protein-9 Controls Pulmonary Vascular Growth and Remodeling
2025ArticleProceedings of the National Academy of Sciences of the United States of America
Initial therapy in patients with pulmonary arterial hypertension and cardiovascular comorbidities
2025ArticleEuropean Respiratory Journal
Impact of A Multidisciplinary Team Discussion for Genetic Lung Fibrosis
2025ArticleRespirology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
GHU APHP UPS SITE KREMLIN BICETRE APHP
78 AV DU GENERAL LECLERC, 94275 LE KREMLIN BICETRE CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
The New England journal of medicine · 2025
American journal of respiratory and critical care medicine · 2024
Abstract Rationale Hepatopulmonary syndrome (HPS) is a severe complication of liver diseases characterized by abnormal dilation of pulmonary vessels, resulting in impaired oxygenation. Recent research highlights the pivotal role of liver-produced BMP-9 (bone morphogenetic protein-9) in maintaining pulmonary vascular integrity. Objectives This study aimed to investigate the involvement of BMP-9 in human and experimental HPS. Methods Circulating BMP-9 levels were measured in 63 healthy control subjects and 203 patients with cirrhosis with or without HPS. Two animal models of portal hypertension were employed: common bile duct ligation with cirrhosis and long-term partial portal vein ligation without cirrhosis. Additionally, the therapeutic effect of low-dose BMP activator FK506 was investigated, and the pulmonary vascular phenotype of BMP-9–knockout rats was analyzed. Measurements and Main Results Patients with HPS related to compensated cirrhosis exhibited lower levels of circulating BMP-9 compared with patients without HPS. Patients with severe cirrhosis exhibited consistently low levels of BMP-9. HPS characteristics were observed in animal models, including intrapulmonary vascular dilations and an increase in the alveolar-arterial gradient. HPS development in both rat models correlated with reduced intrahepatic BMP-9 expression, decreased circulating BMP-9 level and activity, and impaired pulmonary BMP-9 endothelial pathway. Daily treatment with FK506 for 2 weeks restored the BMP pathway in the lungs, alleviating intrapulmonary vascular dilations and improving gas exchange impairment. Furthermore, BMP-9–knockout rats displayed a pulmonary HPS phenotype, supporting its role in disease progression. Conclusions The study findings suggest that portal hypertension–induced loss of BMP-9 signaling contributes to HPS development.
American journal of respiratory and critical care medicine · 2025
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Science translational medicine · 2026 · Journal Article
Jones RJ, De Bie EMDD, Deliu N, Ng AYKC, et al.
Journal of hepatology · 2026 · Letter
Thévenot T, Sitbon O, Savale L
American journal of respiratory cell and molecular biology · 2026 · Journal Article
Savale L, Guignabert C
Communications medicine · 2026 · Journal Article
Labarthe A, Varet S, Savale L, Montani D, et al.
American journal of respiratory and critical care medicine · 2026 · Journal Article
Savale L, D'humières T, Bartolucci P, Humbert M
The European respiratory journal · 2025 · Journal Article
Grynblat J, Farges M, Magro P, Savale L, et al.
Respiratory medicine and research · 2025 · Journal Article
Boucly A, Beauvais A, Lacoste-Palasset T, Jevnikar M, et al.
Respiratory medicine and research · 2025 · Journal Article
Chemla D, Beurnier A, Gerges C, Jaïs X, et al.
American journal of respiratory and critical care medicine · 2025 · Journal Article
Savale L, d'Humières T, Boucly A, Habibi A, et al.
Current opinion in pulmonary medicine · 2025 · Journal Article
Aguado B, Grynblat J, Budhram B, Ghigna MR, et al.
Annals of the rheumatic diseases · 2025 · Journal Article
Boucly A, Mitrovic S, Carmagnat M, Savale L, et al.
Proceedings of the National Academy of Sciences of the United States of America · 2025 · Journal Article
Berrebeh N, Mbouamboua Y, Thuillet R, Ottaviani M, et al.
American journal of respiratory and critical care medicine · 2025 · Letter
Olsson KM, Savale L, Guignabert C, Park DH, et al.
The New England journal of medicine · 2025 · Journal Article
Humbert M, McLaughlin VV, Badesch DB, Ghofrani HA, et al.
Archives of cardiovascular diseases · 2025 · Journal Article
Valdeolmillos E, Boucly A, Humbert M, Sitbon O, et al.
JHEP reports : innovation in hepatology · 2025 · Journal Article
Robert F, Benchenouf F, Ha MN, Cuomo A, et al.
Circulation. Cardiovascular interventions · 2025 · Clinical Trial, Phase III
Gerges C, Jevnikar M, Brenot P, Savale L, et al.
Respiratory medicine and research · 2024 · Journal Article
Boucly A, Bertoletti L, Fauvel C, Dewavrin MG, et al.
Respiratory medicine and research · 2024 · Journal Article
Pham T, Morin L, Savale L, Colle R, et al.
American journal of respiratory and critical care medicine · 2024 · Journal Article
Robert F, Certain MC, Baron A, Thuillet R, et al.
BJA open · 2026 · Journal Article
Nourian MM, Delaporte A, Wingert T, Boulos NM, et al.
Journal of the American College of Cardiology · 2025 · Journal Article
Bertoletti L, Escal J, Boucly A, Turquier S, et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026 · Journal Article
DuBrock HM, Savale L, Sitbon O, Raevens S, et al.
Pulmonary circulation · 2025 · Journal Article
Kolaitis NA, Barnes H, Levine DJ, Castillo H, et al.
ERJ open research · 2025 · Journal Article
Cuomo A, Normand C, Thuillet R, Jaffrezic T, et al.
The European respiratory journal · 2025 · Letter
Jevnikar M, Brenot P, Kularatne M, Rodière A, et al.
JAMA network open · 2025 · Journal Article
Harrois A, Jouffroy R, Ayed S, Bruel C, et al.
Respirology (Carlton, Vic.) · 2025 · Journal Article
Franco G, Ba I, Nathan N, Guerin C, et al.
CJC pediatric and congenital heart disease · 2025 · Journal Article
Valdeolmillos E, Fournier E, Sakhi H, Vignaud P, et al.
Journal of the American College of Cardiology · 2025 · Journal Article
Bertoletti L, Escal J, Boucly A, Turquier S, et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026 · Journal Article
DuBrock HM, Savale L, Sitbon O, Raevens S, et al.
Journal of psychosomatic research · 2024 · Journal Article
Gasnier M, Lecoq AL, Pham T, Morin L, et al.
Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study
Abstract Purpose At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation. Materials, patients and methods We aimed at assessing the relevance
Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study
Abstract Purpose At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation. Materials, patients and methods We aimed at assessing the relevance
International registry of congenital porto-systemic shunts: a multi-centre, retrospective and prospective registry of neonates, children and adults with congenital porto-systemic shunts
Abstract Background Congenital portosystemic shunts (CPSS) are rare vascular malformations associated with the risk of life-threatening systemic conditions, which remain underdiagnosed and often are identified after cons
Cardiovascular and connective tissue disorder features in FLNA-related PVNH patients: progress towards a refined delineation of this syndrome
Abstract Background FLNA Loss-of-Function (LoF) causes periventricular nodular heterotopia type 1 (PVNH1), an acknowledged cause of seizures of various types. Neurological symptoms are inconstant, and cardiovascular (CV)
Cardiovascular and connective tissue disorder features in FLNA-related PVNH patients: progress towards a refined delineation of this syndrome
Abstract Background FLNA Loss-of-Function (LoF) causes periventricular nodular heterotopia type 1 (PVNH1), an acknowledged cause of seizures of various types. Neurological symptoms are inconstant, and cardiovascular (CV)
Additional file 1 of Cardiovascular and connective tissue disorder features in FLNA-related PVNH patients: progress towards a refined delineation of this syndrome
Additional file 1: Data S1. Cohort 1.
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).