Docteur Nicolas ROSINE

Bibliographie

• T cells in the pathogenesis of axial spondyloarthritis

  2023

  ArticleJoint Bone Spine

• Characterization of Blood Mucosal Associated Invariant T ( MAIT ) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis

  2022

  ArticleArthritis & rheumatology

• Adult-Onset Still's Disease or Systemic-Onset Juvenile Idiopathic Arthritis and Spondyloarthritis: Overlapping Syndrome or Phenotype Shift?

  2022

  ArticleRheumatology

• Erratum to: Adult-onset Still's Disease or Systemic-Onset Juvenile Idiopathic Arthritis and Spondyloarthritis: Overlapping Syndrome or Phenotype Shift?

  2022

  ArticleRheumatology

• Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo

  2020

  ArticleAnnals of the Rheumatic Diseases

• Efficacité et sécurité de l’anakinra dans la goutte associée à une insuffisance rénale chronique de stade 4 ou 5 ou à une transplantation rénale : étude rétrospective multicentrique

  2019

  ArticleRevue du Rhumatisme

• Increase In Il-31 Serum Levels Is Associated With Reduced Structural Damage In Early Axial Spondyloarthritis

  2018

  ArticleScientific Reports

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

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• GHSIF SITE MELUN-SENART

  270 Avenue MARC JACQUET, 77000 Melun

  ☎ 0181741717Hospitalier🏥 Voir cet établissement
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Top publications · les plus citées

• 1

  Innate Cells: The Alternative Source of IL-17 in Axial and Peripheral Spondyloarthritis?

  Frontiers in immunology · 2020

  📚 40 citations🎯 RCR 2.67Top 19% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Spondyloarthritis (SpA) is a chronic inflammatory rheumatism characterized by inflammation of sacroiliac joints, peripheral joints, and spine. The Assessment of SpondyloArthritis Society describes three disease forms: axial (axSpA), peripheral, and enthesitic SpA. Each may be associated with extra-articular manifestations: psoriasis, inflammatory bowel disease, and acute anterior uveitis. Genome-wide association studies performed in axSpA and psoriatic arthritis (PsA) have shown a shared genetic background, especially the interleukin 23 (IL-23)/IL-17 pathway, which suggests pathophysiological similarities. The convincing positive results of clinical trials assessing the effect of secukinumab and ixekizumab (anti-IL-17A monoclonal antibodies) in axSpA and PsA have reinforced the speculated crucial role of IL-17 in SpA. Nevertheless, and obviously unexpectedly, the differential efficacy of anti-IL-23–targeted treatments between axSpA (failure) and PsA (success) has profoundly disrupted our presumed knowledge of disease pathogeny. The cells able to secrete IL-17, their dependence on IL-23, and their respective role according to the clinical form of the disease is at the heart of the current debate to potentially explain these observed differences in efficacy of IL-23/IL-17–targeted therapy. In fact, IL-17 secretion is usually mainly related to T helper 17 lymphocytes. Nevertheless, several innate immune cells express IL-23 receptor and can produce IL-17. To what extent these alternative cell populations can produce IL-17 independent of IL-23 and their respective involvement in axSpA and PsA are the crucial scientific questions in SpA. From this viewpoint, this is a nice example of a reverse path from bedside to bench, in which the results of therapeutic trials allow for reflecting more in depth on the pathophysiology of a disease. Here we provide an overview of each innate immunity-producing IL-17 cell subset and their respective role in disease pathogeny at the current level of our knowledge.

• 2

  Characterization of Blood Mucosal-Associated Invariant T Cells in Patients With Axial Spondyloarthritis and of Resident Mucosal-Associated Invariant T Cells From the Axial Entheses of Non-Axial Spondyloarthritis Control Patients

  Arthritis & rheumatology (Hoboken, N.J.) · 2022

  📚 34 citations🎯 RCR 2.80Top 18% NIH🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  ObjectiveThe importance of interleukin‐17A (IL‐17A) in the pathogenesis of axial spondyloarthritis (SpA) has been demonstrated by the success of IL‐17A blockade. However, the nature of the cell populations that produce this important proinflammatory cytokine remains poorly defined. We undertook this study to characterize the major IL‐17A–producing blood cell populations in the peripheral blood of patients with axial SpA, with a focus on mucosal‐associated invariant T (MAIT) cells, a population known to be capable of producing IL‐17.MethodsWe evaluated IL‐17A production from 5 sorted peripheral blood cell populations, namely, MAIT cells, γδ T cells, CD4+ T cells, CD8+ T cells, and neutrophils, before and after stimulation with phorbol myristate acetate, the calcium ionophore A23187, and β‐1,3‐glucan. Expression of IL‐17A transcripts and protein were determined using nCounter and ultra‐sensitive Simoa technology, respectively. MAIT cells from the axial entheses of non‐axial SpA control patients (n = 5) were further characterized using flow cytometric immunophenotyping and quantitative polymerase chain reaction, and the production of IL‐17 was assessed following stimulation.ResultsOn a per‐cell basis, MAIT cells from peripheral blood produced the most IL‐17A compared to CD4+ T cells (P < 0.01), CD8+ T cells (P < 0.0001), and γδ T cells (P < 0.0001). IL‐17A was not produced by neutrophils. Gene expression analysis also revealed significantly higher expression of IL17A and IL23R in MAIT cells. Stimulation of peripheral blood MAIT cells with anti‐CD3/CD28 and IL‐7 and/or IL‐18 induced strong expression of IL17F. MAIT cells were present in the normal, unaffected entheses of control patients who did not have axial SpA and showed elevated AHR, JAK1, STAT4, and TGFB1 transcript expression with inducible IL‐17A protein. IL‐18 protein expression was evident in spinal enthesis digests.ConclusionBoth peripheral blood MAIT cells and resident MAIT cells in normal axial entheses contribute to the production of IL‐17 and may play important roles in the pathogenesis of axial SpA.

• 3

  Effectiveness and safety of anakinra in gout patients with stage 4-5 chronic kidney disease or kidney transplantation: A multicentre, retrospective study

  Joint bone spine · 2018

  📚 34 citations🎯 RCR 1.38

Publications scientifiques (16) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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