📇 Rhumatologue · COLOMBES · (92) · Salarié

MME MARIA ROCA

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Auteur de référence en rhumatologie
30 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
136 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 COLOMBES (92)SalariéRPPS 10100659076

📊 Reconnaissance scientifique : 34/100📝 109 articles publiés

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

34 articles ont été cités au moins 34fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease

Journal of pediatric gastroenterology and nutrition · 2022

📚 126 citations🎯 RCR 15.71Top 1% NIH🔓 Open Access

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There is a need for consensus on the recommendations for follow‐up of children and adolescents with celiac disease.Objectives:To gather the current evidence and to offer recommendations for follow‐up and management.Methods:The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essential for follow‐up care. A literature search (January 2010–March 2020) was performed in PubMed or Medline. Relevant publications were identified and potentially eligible studies were assessed. Statements and recommendations were developed and discussed by all coauthors. Recommendations were voted upon: joint agreement was set as at least 85%.Results:Publications (n = 2775) were identified and 164 were included. Using evidence or expert opinion, 37 recommendations were formulated on: The need to perform follow‐up, its frequency and what should be assessed, how to assess adherence to the gluten‐free diet, when to expect catch‐up growth, how to treat anemia, how to approach persistent high serum levels of antibodies against tissue‐transglutaminase, the indication to perform biopsies, assessment of quality of life, management of children with unclear diagnosis for which a gluten‐challenge is indicated, children with associated type 1 diabetes or IgA deficiency, cases of potential celiac disease, which professionals should perform follow‐up, how to improve the communication to patients and their parents/caregivers and transition from pediatric to adult health care.Conclusions:We offer recommendations to improve follow‐up of children and adolescents with celiac disease and highlight gaps that should be investigated to further improve management.

Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

Journal of translational medicine · 2022

📚 100 citations🎯 RCR 8.41Top 3% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Background Triple negative breast cancer (TNBC) is an aggressive disease characterized by high risk of relapse and development of resistance to different chemotherapy agents. Several targeted therapies have been investigated in TNBC with modest results in clinical trials. Among these, PI3K/AKT inhibitors have been evaluated in addition to standard therapies, yielding conflicting results and making attempts on elucidating inherent mechanisms of resistance of great interest. Increasing evidences suggest that PI3K/AKT inhibitors can induce autophagy in different cancers. Autophagy represents a supposed mechanism of drug-resistance in aggressive tumors, like TNBC. We, therefore, investigated if two PI3K/AKT inhibitors, ipatasertib and taselisib, could induce autophagy in breast cancer models, and whether chloroquine (CQ), a well known autophagy inhibitor, could potentiate ipatasertib and taselisib anti-cancer effect in combination with conventional chemotherapy. Methods The induction of autophagy after ipatasertib and taselisib treatment was evaluated in MDAMB231, MDAM468, MCF7, SKBR3 and MDAB361 breast cancer cell lines by assaying LC3-I conversion to LC3-II through immunoblotting and immunofluorescence. Other autophagy-markers as p62/SQSTM1 and ATG5 were evaluated by immunoblotting. Synergistic antiproliferative effect of double and triple combinations of ipatasertib/taselisib plus CQ and/or paclitaxel were evaluated by SRB assay and clonogenic assay. Anti-apoptotic effect of double combination of ipatasertib/taselisib plus CQ was evaluated by increased cleaved-PARP by immunoblot and by Annexin V- flow cytometric analysis. In vivo experiments were performed on xenograft model of MDAMB231 in NOD/SCID mice. Results Our results suggested that ipatasertib and taselisib induce increased autophagy signaling in different breast cancer models. This effect was particularly evident in PI3K/AKT resistant TNBC cells, where the inhibition of autophagy by CQ potentiates the therapeutic effect of PI3K/AKT inhibitors in vitro and in vivo TNBC models, synergizing with taxane-based chemotherapy. Conclusion These data suggest that inhibition of authophagy with CQ could overcome mechanism of drug resistance to PI3K/AKT inhibitors plus paclitaxel in TNBC making the evaluation of such combinations in clinical trials warranted.

Investigating the Effects of COVID-19 Quarantine in Migraine: An Observational Cross-Sectional Study From the Italian National Headache Registry (RICe)

Frontiers in neurology · 2020

📚 40 citations🎯 RCR 2.95Top 17% NIH🔓 Open Access📄 PDF gratuit ↗

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Publications scientifiques (30) — classées par pathologie

Pédiatrie11

Transversal11

Épidémiologie & registres4

Gériatrie2

Case report / série1

Essai clinique1

Revue / méta-analyse1

Revue générale1

Santé mentale / fatigue1

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