📇 Rhumatologue · PERPIGNAN CEDEX 9 · (66) · Salarié
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Praticien-chercheur
6 articles scientifiques publiés — formation continue solide
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
138.3 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
PLATE FORME SAMU SDIS 66
1 R DU LIEUTENANT GOURBAULT BP 19935, 66962 PERPIGNAN CEDEX 9
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Arthritis & rheumatology (Hoboken, N.J.) · 2018
ObjectiveUp to one‐third of patients with T cell large granular lymphocyte (T‐LGL) leukemia display symptoms of rheumatoid arthritis (RA). In Crohn's disease and psoriasis, treatment with tumor necrosis factor (TNF) inhibitors is associated with hepatosplenic γδ T cell lymphoma and with clonal expansion of γδ T cells, respectively. This study was undertaken to determine the prevalence of clonal T‐LGL cells in patients with RA and define risk factors for this rare hematologic malignancy.MethodsA total of 529 RA patients were recruited between November 2013 and August 2015. Eight‐color flow cytometry (fluorescence‐activated cell sorting [FACS]) was performed to screen for aberrant T cell populations of LGLs. Molecular analysis of the T cell receptor was used to confirm the diagnosis in patients with suggestive FACS findings. Electronic patient files were used to determine risk factors. Patients with clonal populations were monitored prospectively for up to 4 years.ResultsThe median patient age was 61 years, and 74% were female. The median duration of RA was 12 years. The median Disease Activity Score in 28 joints was 2.8, and 69.9% of patients had ever been treated with biologic disease‐modifying antirheumatic drugs. We identified clonal T‐LGL expansions in 19 patients, equaling a prevalence of 3.6%. The T‐LGL cell clone was constant over time in most patients and was significantly associated with the duration of the exposure to TNF‐blocking agents (P = 0.01). No other risk factors could be detected.ConclusionRA patients with long‐term exposure to TNF‐blocking agents were at a greater risk of developing clonal expansions of LGLs. This finding may prompt clinicians to refrain from using these substances in RA patients with known T cell aberrations.
European journal of dermatology : EJD · 2008
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2009
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2009 · Case Reports
Sohl S, Renner R, Winter U, Bodendorf M, et al.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia · 2009 · Journal Article
Renner R, Sticherling M
European journal of dermatology : EJD · 2008 · Case Reports
Renner R, Sticherling M
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2009 · Case Reports
Sohl S, Renner R, Winter U, Bodendorf M, et al.
Arthritis & rheumatology (Hoboken, N.J.) · 2018 · Journal Article
Schwaneck EC, Renner R, Junker L, Einsele H, et al.
Journal of the European Academy of Dermatology and Venereology : JEADV · 2008 · Case Reports
Schlaak M, Friedlein H, Kauer F, Renner R, et al.
Scandinavian journal of rheumatology · 2020 · Journal Article
Schwaneck EC, Renner R, Junker L, Tony HP, et al.