Docteur PIERRE QUILLET

Bibliographie

• Six ans de PCR « Réseau de lithothèques » en région Centre Val de Loire

  2022

  CongrèsJournées de la Société préhistorique française : PCR « Réseau de lithothèques » et GDR « Silex » – Bilan de 15 ans d’approche dynamique des silicites

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Articles de presse (5)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

• Pierre Quillet est mort - Le Parisien

  📰 Le Parisien · 17/12/2007

  <a href="https://news.google.com/rss/articles/CBMimAFBVV95cUxNZWZhNlNUT2RveWZlWFZWYmd3T1lhTjcxU19vRGRoOXNsUzlmeXNWcVdHa0xrblhQTFpjMkRmT3BKOUM1ZUF6Y3hkZ2JWaXYzZjNYdktDR1h2Z0I4QU5QbmRIWXdaenJKOU9MYm1adk1sQ0VZSWN1cEtQYU1QQVduOC0xZlFzUl9CWlozZUtFWi1naWJCWWQ5Sw?oc=5" target="_blank">Pierre Quillet est mo

• Vainqueurs, les Romains obligent les Gaulois à évacuer leur village fortifié : que s'est-il passé à Drevant et La Groutte - Le Berry Républicain

  📰 Le Berry Républicain · 30/07/2025

  <a href="https://news.google.com/rss/articles/CBMi7gFBVV95cUxOSzNCRmtVQXdMRlVrbmRfZVRrZmw5S2VJUU0xZnNUWm5HaHBwbkFkRmo2TEdWdnhBY0J1MG9SN091RUR5Qk9TQkZaLThxSG9UaFRrT2l6R3gxdFduV21QelpnQk1ndVI0dm9kdEpEdnJYcldjZGFuRnVNS1RkWE55aGo1M2Z4Ulp0dFlWUDBZVXhMOUFseHRPYlJCb0hhSFV0TFhQZlFib250Zk9xU2RFTUN6bDVxWXlQbU

• " Une saison en demi-teinte " - lanouvellerepublique.fr

  📰 lanouvellerepublique.fr · 06/10/2014

  <a href="https://news.google.com/rss/articles/CBMiekFVX3lxTE5hVjB6LXR5ZUpCeTdXN2RyZmZGdGQ0VEQ3eE4zSmhMSXRDMU04WDM1VVd0cWJMS3ZuajZlMkI0Ulo1Z1lCdEtKWlNqVXlqMGstOURxT0RiYWZqOFB4cFRnckU1T0JQTVp3VXRnVTI0Y05kNDlDS2Z1MTdB?oc=5" target="_blank">" Une saison en demi-teinte "</a>&nbsp;&nbsp;<font color="#6f6f

• Meaux : la fracture sociale compromet la réélection de Jean-François Copé - Les Echos

  📰 Les Echos · 30/01/2001

  <a href="https://news.google.com/rss/articles/CBMirwFBVV95cUxPMmVqZjdINHBjSkFTeVAwd0ZITEUxUEotbEJkQWNKOW1WSFMta2x0d3hrZWRTdDU4VHpsZkRGU0JFZjA2Vms3aTRtcVdzdThfSk42clVfTWJld0FablEtRkMyU01ma1liaDJGM0pKTmI4aHlDejJ4b3JvcUNlQ1d2N290RXVkYTlSN0lpc2FEMG9Ld3FuQ1NsME9FWTJCZE9acXhRR3NqbEVEX2ZFaTlz?oc=5" target=

• La mort aux courses un samedi à La Roche-Posay - lanouvellerepublique.fr

  📰 lanouvellerepublique.fr · 18/06/2012

  <a href="https://news.google.com/rss/articles/CBMisgFBVV95cUxNNXhjUmJPUTl1STVGS2ZEb3UxRnVGbHFVTTdmSkNydXZQeUxaRTVsOGozeWV4MURERVBQYmVXNnJObE9ZX2F6ZHVZbDZjUzRMUFdhUWVwTFhZZkYyQkZCbmRBWHFVeF9Wc0RWYUZMNVlkTkQxd0Q0MjBUMmFRVmFUTC04TFpSMkh4NmpVX2ZpSzNNcDJZdzNfV3pfYTc3dDYySThmWkFpZDJXRmxrRkwwMHFB?oc=5" tar

Top publications · les plus citées

• 1

  New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility

  Arthritis and rheumatism · 2005

  📚 146 citations🎯 RCR 3.41Top 14% NIH

  Lire l'abstract Crossref ↓

  AbstractObjectiveThe shared epitope hypothesis was formulated to explain the involvement of HLA–DRB1 in rheumatoid arthritis (RA). However, several studies, which considered only the HLA–DRB1 alleles shown to be associated with RA risk, rejected this hypothesis. In this report, we propose that a different classification of HLA–DRB1 alleles be considered, based on the amino acid sequence at position 70–74.MethodsThe fit of both HLA–DRB1 classifications was tested in 2 groups of RA patients. All subjects were recruited through the European Consortium on Rheumatoid Arthritis Families, and included 100 patients with isolated RA and 132 patients with at least 1 affected sibling.ResultsThe new classification produced risk estimates that fit all of the observed data, i.e., the distribution of the HLA–DRB1 genotype in the 2 patient groups, and the distribution of parental alleles shared by affected sibpairs. The risk of developing RA under this new classification depends on whether the RAA sequence occupies position 72–74 but is modulated by the amino acid at position 71 (K confers the highest risk, R an intermediate risk, A and E a lower risk) and by the amino acid at position 70 (Q or R confers a higher risk than D).ConclusionA new classification based on amino acid sequence allows us to show that the shared epitope RAA sequence at position 72–74 explains the data, with the risk of developing RA modulated by the amino acids at positions 70 and 71.

• 2

  Dense genome-wide linkage analysis of rheumatoid arthritis, including covariates

  Arthritis and rheumatism · 2004

  📚 66 citations🎯 RCR 1.46

  Lire l'abstract Crossref ↓

  AbstractObjectiveRheumatoid arthritis (RA) is a heterogeneous disease that exhibits a complex genetic component. Previous RA genome scans confirmed the involvement of the HLA region and generated data on suggestive signals at non‐HLA regions, albeit with few overlaps in findings between studies. The present study was undertaken to detect potential RA gene regions and to estimate the number of true RA gene regions, taking into account the heterogeneity of RA, through performance of a dense genome scan.MethodsIn a study of 88 French Caucasian families (105 RA sibpairs), 1,088 microsatellite markers were genotyped (3.3‐cM genome scan), and a multipoint model‐free linkage analysis was performed. The statistical assessment of the results relied on 10,000 computer simulations. A covariate‐based multipoint model‐free linkage analysis was performed on the locations of regions with suggestive evidence for linkage.ResultsInvolvement of the HLA region was strongly confirmed (P = 6 × 10−5), and 19 non‐HLA regions showed suggestive evidence for linkage (P &lt; 0.05); 9 of these overlapped with regions suggested in other published RA genome scans. A routine 12‐cM genome scan with the same families would have detected only 7 of the 19 regions, including only 4 of the 9 overlapping regions. From the 10,000 computer simulations, we estimated that 8 ± 4 regions (mean ± SD) were true‐positives. RA covariate–based analysis provided additional linkage evidence for 3 regions, with age at disease onset, erosions, and HLA–DRB1 shared epitope as covariates.ConclusionThe results of this study provide evidence of 19 non‐HLA RA gene regions, with an estimate of 8 ± 4 as true‐positives, and provide additional evidence for 3 regions from covariate‐based analysis.

• 3

  Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis

  Arthritis research & therapy · 2006

  📚 48 citations🎯 RCR 1.13🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  AbstractRecently, we proposed a classification of HLA-DRB1 alleles that reshapes the shared epitope hypothesis in rheumatoid arthritis (RA); according to this model, RA is associated with the RAA shared epitope sequence (72–74 positions) and the association is modulated by the amino acids at positions 70 and 71, resulting in six genotypes with different RA risks. This was the first model to take into account the association between the HLA-DRB1 gene and RA, and linkage data for that gene. In the present study we tested this classification for validity in an independent sample. A new sample of the same size and population (100 RA French Caucasian families) was genotyped for the HLA-DRB1 gene. The alleles were grouped as proposed in the new classification: S1 alleles for the sequences A-RAA or E-RAA; S2 for Q or D-K-RAA; S3D for D-R-RAA; S3P for Q or R-R-RAA; and X alleles for no RAA sequence. Transmission of the alleles was investigated. Genotype odds ratio (OR) calculations were performed through conditional logistic regression, and we tested the homogeneity of these ORs with those of the 100 first trio families (one case and both parents) previously reported. As previously observed, the S2 and S3P alleles were significantly over-transmitted and the S1, S3D and X alleles were under-transmitted. The latter were grouped as L alleles, resulting in the same three-allele classification. The risk hierarchy of the six derived genotypes was the same: (by decreasing OR and with L/L being the reference genotype) S2/S3P, S2/S2, S3P/S3P, S2/L and S3P/L. The homogeneity test between the ORs of the initial and the replication samples revealed no significant differences. The new classification was therefore considered validated, and both samples were pooled to provide improved estimates of RA risk genotypes from the highest (S2/S3P [OR 22.2, 95% confidence interval 9.9–49.7]) to the lowest (S3P/L [OR 4.4, 95% confidence interval 2.3–8.4]).

Publications scientifiques (5) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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