📇 Rhumatologue · CHERBOURG OCTEVILLE CEDEX · (50) · Salarié

M GUILLAUME QUEFFEULOU

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10 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
107.5 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 CHERBOURG OCTEVILLE CEDEX (50)SalariéRPPS 10000623131

📊 Reconnaissance scientifique : 9/100📝 20 articles publiés🇫🇷 Publications académiques françaises (6)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Factors affecting outcome and prognosis in membranous lupus nephropathy

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2002

📚 77 citations🎯 RCR 2.06

Vimentin affects localization and activity of sodium-glucose cotransporter SGLT1 in membrane rafts

Journal of cell science · 2002

📚 59 citations🎯 RCR 1.19

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It has been reported that vimentin, a cytoskeleton filament that is expressed only in mesenchymal cells after birth, is re-expressed in epithelial cells in vivo under pathological conditions and in vitro in primary culture. Whether vimentin re-expression is only a marker of cellular dedifferentiation or is instrumental in the maintenance of cell structure and/or function is a matter of debate. To address this issue, we used renal proximal tubular cells in primary culture from vimentin-null mice (Vim-/-) and from wild-type littermates (Vim+/+). The absence of vimentin did not affect cell morphology, proliferation and activity of hydrolases, but dramatically decreased Na-glucose cotransport activity. This phenotype was associated with a specific reduction of SGLT1 protein in the detergent-resistant membrane microdomains (DRM). In Vim+/+cells, disruption of these microdomains by methyl-β-cyclodextrin decreased SGLT1 protein abundance in DRM, a change that was paralleled by a decrease of Na-glucose transport activity. Importantly, we showed that vimentin is located to DRM, but it disappeared after methyl-β-cyclodextrin treatment. In Vim-/- cells,supplementation of cholesterol with cholesterol-methyl-β-cyclodextrin complexes completely restored Na-glucose transport activity. Interestingly,neither cholesterol content nor cholesterol metabolism changed in Vim-/- cells. Our results are consistent with the view that re-expression of vimentin in epithelial cells could be instrumental to maintain the physical state of rafts and, thus, the function of DRM-associated proteins.

Are all dialyzers compatible with the convective volumes suggested for postdilution online hemodiafiltration?

The International journal of artificial organs · 2016

📚 37 citations🎯 RCR 2.43Top 21% NIH

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Introduction The recent analysis of 4 randomized controlled trials has confirmed the lower mortality risk for postdilution online hemodiafiltration (OL-HDF) compared to hemodialysis, and above all for patients with the highest delivered body surface area standardized convective volume (CV/BSA >23 L/1.73 m 2 /session). Since the impact of the dialyzers used in these trials has never been studied, we retrospectively analyzed clinical tests carried out with 19 commonly used dialyzers. The aim was to provide information on their performances and behavior to aid in an objective choice for therapies associated with OL-HDF. Methods “Efficiency” was evaluated by measuring the reduction ratio of beta-2 microglobulin (RRß2M) and myoglobin (RRmyo) for a CV/BSA between 0 and 30 L, extrapolating them at CV/BSA = 23 L “Safety” was defined by the safe CV (CVsafe), corresponding to the CV/BSA above which albumin loss is >5 g/session. Results: With CV/BSA = 23 L, all the dialyzers ensure an optimal ß2M extraction (RRß2M: 76%–84.5%). For myoglobin, efficiency disparities are bigger (RRmyo: 40%–85%). Above all, 4/19 dialyzers lose more than 5 g albumin and should not be used under these conditions. Conclusions It is recommended to prescribe dialyzers that are above all safe. Moreover, if one considers that the removal of middle molecule solutes prevails over the CV necessary for their transmembrane transport, some dialyzers that are more efficient with CV/BSA <23 L than others with CV/BSA >= 23 L might then be prescribed when the conditions do not permit the suggested CV/BSA goal to be achieved.

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M GUILLAUME QUEFFEULOU

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Activité de recherche & publications

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (10) — classées par pathologie

Transversal8

Gériatrie1

Lupus1

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