Docteur DOMINIQUE PIATIER-TONNEAU

• Analyse de la région chromosomique 7q34-35 dans le cancer du sein : PIP et ARHGEF5, deux gènes sujets à des altérations

  2003

  Doctorant·e : Marina Ciullo

  Sciences biologiques🎓 Paris 11

• Etude de la gp17, un marqueur des sécrétions apocrines : conséquences fonctionnelles de l'interaction gp17/CD4 sur la sensibilité des lymphocytes T CD4+ à la stimulation du récepteur de l'antigène

  2000

  Doctorant·e : Stéphane Basmaciogullari

  Immunologie🎓 Paris 11

• Caractérisation moléculaire et fonctionnelle de la gp17, un nouveau ligand de CD4 : étude du gène gp17 dans le cancer de la prostate

  1999

  Doctorant·e : Monica Autiero Luka

  Immunologie🎓 Paris 11

Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).

Bibliographie

• A Functional and Regulatory Network Associated with PIP Expression in Human Breast Cancer

  2009

  ArticlePLoS ONE

• Deciphering cellular states of innate tumor drug responses

  2006

  ArticleGenome Biology

• Integrative annotation of 21,037 human genes validated by full-length cDNA clones.

  2004

  ArticlePLoS Biology

• Mapping the CD4 Binding Domain of gp17, a Glycoprotein Secreted from Seminal Vesicles and Breast Carcinomas

  2000

  ArticleBiochemistry

• Abnormal Restriction Pattern of PIP Gene Associated with Human Primary Prostate Cancers

  1999

  ArticleDNA and Cell Biology

• Potent inhibition of CD4/TCR-mediated T cell apoptosis by a CD4-binding glycoprotein secreted from breast tumor and seminal vesicle cells.

  1999

  ArticleJournal of Immunology

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

Lieu de consultation

Tarifs & secteur de conventionnement

Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

Prendre rendez-vous & contact

Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).

Top publications · les plus citées

• 1

  Integrative annotation of 21,037 human genes validated by full-length cDNA clones

  PLoS biology · 2004

  📚 251 citations🎯 RCR 4.30Top 10% NIH🔓 Open Access📄 PDF gratuit ↗
• 2

  Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I

  Human molecular genetics · 2002

  📚 128 citations🎯 RCR 2.13Top 25% NIH🔓 Open Access📄 PDF gratuit ↗
• 3

  Deciphering cellular states of innate tumor drug responses

  Genome biology · 2006

  📚 105 citations🎯 RCR 1.88🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Abstract Background The molecular mechanisms underlying innate tumor drug resistance, a major obstacle to successful cancer therapy, remain poorly understood. In colorectal cancer (CRC), molecular studies have focused on drug-selected tumor cell lines or individual candidate genes using samples derived from patients already treated with drugs, so that very little data are available prior to drug treatment. Results Transcriptional profiles of clinical samples collected from CRC patients prior to their exposure to a combined chemotherapy of folinic acid, 5-fluorouracil and irinotecan were established using microarrays. Vigilant experimental design, power simulations and robust statistics were used to restrain the rates of false negative and false positive hybridizations, allowing successful discrimination between drug resistance and sensitivity states with restricted sampling. A list of 679 genes was established that intrinsically differentiates, for the first time prior to drug exposure, subsequently diagnosed chemo-sensitive and resistant patients. Independent biological validation performed through quantitative PCR confirmed the expression pattern on two additional patients. Careful annotation of interconnected functional networks provided a unique representation of the cellular states underlying drug responses. Conclusion Molecular interaction networks are described that provide a solid foundation on which to anchor working hypotheses about mechanisms underlying in vivo innate tumor drug responses. These broad-spectrum cellular signatures represent a starting point from which by-pass chemotherapy schemes, targeting simultaneously several of the molecular mechanisms involved, may be developed for critical therapeutic intervention in CRC patients. The demonstrated power of this research strategy makes it generally applicable to other physiological and pathological situations.

Publications scientifiques (13) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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