📇 Rhumatologue · LA ROCHE SUR YON CEDEX 9 · (85) · Salarié

M PHILIPPE PERRE

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Auteur de référence en rhumatologie
28 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
97.1 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LA ROCHE SUR YON CEDEX 9 (85)SalariéRPPS 10003828588

📊 Reconnaissance scientifique : 74/100📝 662 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

One Health surveillance of West Nile and Usutu viruses: a repeated cross-sectional study exploring seroprevalence and endemicity in Southern France, 2016 to 2020

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022

📚 36 citations🎯 RCR 5.09Top 8% NIH🔓 Open Access📄 PDF gratuit ↗

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Background West Nile virus (WNV) and Usutu virus (USUV), two closely related flaviviruses, mainly follow an enzootic cycle involving mosquitoes and birds, but also infect humans and other mammals. Since 2010, their epidemiological situation may have shifted from irregular epidemics to endemicity in several European regions; this requires confirmation, as it could have implications for risk assessment and surveillance strategies. Aim To explore the seroprevalence in animals and humans and potential endemicity of WNV and USUV in Southern France, given a long history of WNV outbreaks and the only severe human USUV case in France in this region. Methods We evaluated the prevalence of WNV and USUV in a repeated cross-sectional study by serological and molecular analyses of human, dog, horse, bird and mosquito samples in the Camargue area, including the city of Montpellier, between 2016 and 2020. Results We observed the active transmission of both viruses and higher USUV prevalence in humans, dogs, birds and mosquitoes, while WNV prevalence was higher in horses. In 500 human samples, 15 were positive for USUV and 6 for WNV. Genetic data showed that the same lineages, WNV lineage 1a and USUV lineage Africa 3, were found in mosquitoes in 2015, 2018 and 2020. Conclusion These findings support existing literature suggesting endemisation in the study region and contribute to a better understanding of USUV and WNV circulation in Southern France. Our study underlines the importance of a One Health approach for the surveillance of these viruses.

Long-term persistence of mitochondrial dysfunctions after viral infections and antiviral therapies: A review of mechanisms involved

Journal of medical virology · 2024

📚 16 citations🎯 RCR 3.50Top 13% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged. Quantitative defects and structural rearrangements of mitochondrial DNA accumulate in post‐mitotic tissues as recently reported long after SARS‐CoV‐2 or HIV infection, or following antiviral therapy. These observations are consistent with the “hit‐and‐run” concept proposed decades ago to explain viro‐induced cell transformation and it could apply to delayed post‐viral onsets of symptoms and advocate for complementary supportive care. Thus, according to this concept, following exposure to viruses or antiviral agents, mitochondrial damage could evolve into an autonomous clinical condition. It also establishes a pathogenic link between communicable and non‐communicable chronic diseases.

Preventing breast milk HIV transmission using broadly neutralizing monoclonal antibodies: One size does not fit all

Immunity, inflammation and disease · 2024

📚 11 citations🎯 RCR 2.44Top 21% NIH🔓 Open Access📄 PDF gratuit ↗

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Key messages Passive immunoprophylaxis with broadly neutralizing monoclonal antibodies (bNAbs) could be a game changer in the prevention of human immunodeficiency virus (HIV) acquisition. The prevailing view is that available resources should be focused on identifying a fixed combination of at least three bNAbs for universal use in therapeutic and preventive protocols, regardless of target populations or routes of transmission. HIV transmission through breastfeeding is unique: it involves free viral particles and cell‐associated virus from breast milk and, in the case of acute/recent maternal infection, a viral population with restricted Env diversity. HIV transmission through breastfeeding in high incidence/prevalence areas could potentially be eliminated by subcutaneous administration to all newborns of one or two long‐acting bNAbs with extended breadth, high potency, and effector properties (ADCC, phagocytosis) against circulating HIV strains.

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M PHILIPPE PERRE

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Activité de recherche & publications

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (28) — classées par pathologie

Pédiatrie9

Transversal8

Épidémiologie & registres5

Essai clinique2

Revue générale2

Biomarqueurs / Auto-Ac1

Pharmacovigilance1

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