📇 Rhumatologue · ANNECY · (74) · Mixte

MME CHRISTELLE PAUL-DEVRIES

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Auteur de référence en rhumatologie
27 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 ANNECY (74)MixteRPPS 10003748109

✨ Génération du profil synthétique IA en cours…

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EML SCAN CLINIQUE D'ARGONAY
CLINIQUE D'ARGONAY 685 RTE DE MENTHONNEX PRINGY, 74370 ANNECY
Activité de soin et de pharmacie
EML IRM 74 - SITE ANNECY CESIERE
18 R DE LA CESIERE ZI VOVRAY, 74000 ANNECY
☎ 0450512341Activité de soin et de pharmacie
SELARL IMARA 74

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis

Journal of cellular and molecular medicine · 2009

📚 33 citations🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractThe human kallikrein‐related peptidases (KLK) are serine proteases whose concentrations are often abnormal in common human malignancies and contribute to neoplastic progression through multifaceted roles. However, little attention has been paid to their synthesis and involvement in the development and dissemination of lung cancer, the leading cause of cancer mortality worldwide. We have analysed the production of KLK6 in normal lung and tumour tissues from patients with non‐small cell lung cancer (NSCLC). KLK6 immunoreactivity was restricted to epithelial cells of the normal bronchi, but most of the cancer samples were moderately or highly immunoreactive, regardless of the histological subtype. In contrast, little or no KLK6 was detected in NSCLC cells. We have developed NSCLC lines expressing wild‐type KLK6 in order to investigate the role of KLK6 in lung cancer biology, and analysed its impact on proliferation. Ectopic KLK6 dramatically enhanced NSCLC cell growth and KLK6‐producing NSCLC cells had accelerated cell cycles, between the G1 and S phases. This was accompanied by a marked increase in cyclin E and decrease in p21. KLK6 production was also associated with enhanced synthesis of c‐Myc, which is known to promote cell‐cycle progression. Finally, examination of specimens from patients with NSCLC revealed that KLK6 mRNA is overexpressed in tumour tissue, and high KLK6 concentrations were associated with lower survival rates. We conclude that a high concentration of KLK6 is an indicator of tumour proliferation and an independent predictive factor in NSCLC.

Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations

Current genomics · 2014

📚 30 citations🎯 RCR 1.08🔓 Open Access

Prevalence of rotavirus, adenovirus and enteric parasites among pediatric patients attending Saint Camille Medical Centre in Ouagadougou

Pakistan journal of biological sciences : PJBS · 2007

📚 20 citations🔓 Open Access📄 PDF gratuit ↗

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MME CHRISTELLE PAUL-DEVRIES

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Publications scientifiques (27) — classées par pathologie

Transversal8

Case report / série5

Lupus5

Pédiatrie4

Revue générale3

Corticothérapie1

Épidémiologie & registres1

Essai clinique1

Gériatrie1

Risque cardio-vasculaire1

SAPL1

Vascularites des gros vaisseaux1

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