📇 Rhumatologue · LE MANS CEDEX 9 · (72) · Hospitalier

M Tri-Hung NGUYEN

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3 raisons identifiées

Auteur de référence en rhumatologie
34 articles scientifiques publiés — un praticien à la pointe de la recherche
Expérience confirmée
34 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
77.4 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LE MANS CEDEX 9 (72)HospitalierRPPS 10001726073

Expérience confirmée

34ans d'exercice (thèse 1992)

🇫🇷 Publications académiques françaises (1)

✨ Génération du profil synthétique IA en cours…

Thèses universitaires

Pathologie iatrogenique : effets indesirables des medicaments : contribution a la maintenance du systeme adm

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Body mass index and subsequent fracture risk: a meta-analysis to update FRAX

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025

📚 7 citations🎯 RCR 3.34🔓 Open Access📄 PDF gratuit ↗

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Abstract The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1 667 922 men and women from 32 countries (63 cohorts), followed for a total of 16.0 million person-years were studied. 293 325 had FN BMD measured (2.2 million person-years follow-up). An extended Poisson model in each cohort was used to investigate relationships between WHO-defined BMI categories (Underweight: &lt;18.5 kg/m2; Normal: 18.5-24.9 kg/m2; Overweight: 25.0-29.9 kg/m2; Obese I: 30.0-34.9 kg/m2; Obese II: ≥35.0 kg/m2) and risk of incident osteoporotic, major osteoporotic and hip fracture (HF). Inverse-variance weighted β-coefficients were used to merge the cohort-specific results. For the subset with BMD available, in models adjusted for age and follow-up time, the hazard ratio (95% CI) for HF comparing underweight with normal weight was 2.35 (2.10-2.60) in women and for men was 2.45 (1.90-3.17). Hip fracture risk was lower in overweight and obese categories compared to normal weight [obese II vs normal: women 0.66 (0.55-0.80); men 0.91 (0.66-1.26)]. Further adjustment for FN BMD T-score attenuated the increased risk associated with underweight [underweight vs normal: women 1.69 (1.47-1.96); men 1.46 (1.00-2.13)]. In these models, the protective effects of overweight and obesity were attenuated, and in both sexes, the direction of association reversed to higher fracture risk in Obese II category [Obese II vs Normal: women 1.24 (0.97-1.58); men 1.70 (1.06-2.75)]. Results were similar for other fracture outcomes. Underweight is a risk factor for fracture in both men and women regardless of adjustment for BMD. However, while overweight/obesity appeared protective in base models, they became risk factors after additional adjustment for FN BMD, particularly in the Obese II category. This effect in the highest BMI categories was of greater magnitude in men than women. These results will inform the second iteration of FRAX®.

Efficacy of adipose-derived stem cells and stromal vascular fraction for pain relief in Kellgren-Lawrence grade II-III knee osteoarthritis: A systematic review (2019-2024)

Journal of orthopaedics · 2025

📚 4 citations🔓 Open Access

Development of a First-in-Class Click Chemistry-Based Cancer Therapeutic, from Preclinical Evaluation to a First-in-Human Dose Escalation Clinical Trial

Clinical cancer research : an official journal of the American Association for Cancer Research · 2025

📚 4 citations🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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Abstract Purpose: Achieving precise drug activation without associated toxicities is a significant challenge in developing cancer therapeutics. Click Activated Protodrugs Against Cancer is a pretargeting approach that uses bioorthogonal click chemistry in vivo to selectively capture and activate drugs at tumors and can be applied to a wide variety of targeted therapeutics. The first-in-class Click Activated Protodrugs Against Cancer–based cancer therapeutic SQ3370 uses a clickable pretargeting agent that reacts with a chemically attenuated clickable payload of doxorubicin (Dox) and releases the active cytotoxic drug in situ. Patients and Methods: We describe the preclinical development and translation of SQ3370 to a first-in-human dose-escalation clinical trial in adult patients with advanced solid tumors (NCT04106492). Results: SQ3370 inhibited tumor progression across several mouse tumor models through the safe and selective release of Dox in tumors at concentrations unachievable by conventional treatment. SQ3370 exhibited safety when administered at 8.9 times the veterinary Dox dose in dogs and 15 times the conventional Dox dose in patients, with no reported protocol-defined dose-limiting toxicities. In patients, SQ3370 modulated active Dox pharmacokinetics and enabled T-cell–dependent immune responses, including cytotoxic CD8+ T-cell expansion and activation in tumors and systemically. Conclusions: SQ3370, the first demonstration of click chemistry within the human body in a clinical setting, facilitated the delivery of chemotherapy to tumors and unlocked additional biological effects such as favorable immune responses that may benefit patients with metastasis. Consistent safety, toxicology, pharmacokinetic, and immune activation results observed across species highlight the translatability of the technology and position click chemistry as a powerful new modality for the development of targeted cancer therapeutics.

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M Tri-Hung NGUYEN

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

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Top publications · les plus citées

Publications scientifiques (34) — classées par pathologie

Transversal10

Revue générale5

Ostéoporose3

Case report / série2

Essai clinique2

Goutte2

IA en rhumatologie2

Sjögren2

Épidémiologie & registres1

Génétique1

Gériatrie1

Lombalgie1

Lupus1

Pédiatrie1

Qualité de vie / PROMs1

Recommandations1

Revue / méta-analyse1

Sclérodermie1

Vascularites1

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