📇 Rhumatologue · CAGNES SUR MER · (06) · Libéral

MME VALERIE NEGREL-CHABANCE

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Auteur de référence en rhumatologie
32 articles scientifiques publiés — un praticien à la pointe de la recherche
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📍 CAGNES SUR MER (06)LibéralRPPS 10003299749

✨ Génération du profil synthétique IA en cours…

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19 AVENUE AUGUSTE RENOIR, 06800 CAGNES SUR MER
☎ 0493208126Activité de soin et de pharmacie

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Top publications · les plus citées

Curcumin's effect in advanced and metastatic breast cancer patients treated with first or second-line docetaxel: A randomized trial

Health science reports · 2024

📚 8 citations🎯 RCR 2.21Top 24% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractBackgroundIn this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second‐line treatment potentiated the objective response rate.Patients/MethodsA multicentre, randomized, open label, phase‐II study was conducted and included 42 patients from July 2009 to January 2017. The primary endpoint was the objective response rate of the docetaxel‐curcumin combination in comparison with docetaxel alone. The secondary endpoints were the assessment of clinical benefit, overall survival, time‐to‐progression, progression‐free survival, compliance, and safety. An interim analysis was planned to evaluate safety and efficacy.ResultsIn this interim analysis conducted on 37 patients (19 in the control group vs. 18 in the experimental group), no difference was observed for the objective response rate (p = 0.25, control 73.7% vs. experimental 55.6%). Concerning clinical benefit, overall survival and time‐to‐progression, we also failed to show any difference between the two arms. A slight tendency towards longer progression‐free survival at 12 months after randomization was observed in the curcumin group (65.5% vs. 41.4%) but this difference did not reach significance (p = 0.14).ConclusionIn this study, we showed for the first time that adding oral curcumin for advanced and metastatic breast cancer patients treated with first or second‐line docetaxel was not efficacious, although safe. Consequently, this study was stopped for reasons of futility. Further studies with a larger number of patients, a different curcumin preparation, a longer treatment period and a pharmacokinetic evaluation of curcumin are needed to explore the real efficacy of this compound.

The Brain Tumor Segmentation - Metastases (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI

ArXiv · 2024

📚 7 citations🎯 RCR 2.57Top 20% NIH

Enriching Data Science and Health Care Education: Application and Impact of Synthetic Data Sets Through the Health Gym Project

JMIR medical education · 2024

📚 7 citations🎯 RCR 2.05🔓 Open Access📄 PDF gratuit ↗

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Large-scale medical data sets are vital for hands-on education in health data science but are often inaccessible due to privacy concerns. Addressing this gap, we developed the Health Gym project, a free and open-source platform designed to generate synthetic health data sets applicable to various areas of data science education, including machine learning, data visualization, and traditional statistical models. Initially, we generated 3 synthetic data sets for sepsis, acute hypotension, and antiretroviral therapy for HIV infection. This paper discusses the educational applications of Health Gym’s synthetic data sets. We illustrate this through their use in postgraduate health data science courses delivered by the University of New South Wales, Australia, and a Datathon event, involving academics, students, clinicians, and local health district professionals. We also include adaptable worked examples using our synthetic data sets, designed to enrich hands-on tutorial and workshop experiences. Although we highlight the potential of these data sets in advancing data science education and health care artificial intelligence, we also emphasize the need for continued research into the inherent limitations of synthetic data.

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MME VALERIE NEGREL-CHABANCE

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Top publications · les plus citées

Publications scientifiques (32) — classées par pathologie

Transversal10

Revue générale6

Lupus4

Case report / série3

Essai clinique2

Pédiatrie2

Qualité de vie / PROMs2

Revue / méta-analyse2

AINS1

Anti-TNF1

Économie santé1

Épidémiologie & registres1

Génétique1

Pharmacovigilance1

Vraie vie / RWE1

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