Docteur BENEDICTE MUGNIER

Thèses universitaires

• Prédiction de l'efficacité de l'infliximab dans le traitement de la polyarthrite rhumatoïde : rôle du polymorphisme-308 du gène du Tumor Necrosis Factor alfa

  2003

  Factors predicting responsiveness to infliximab in rheumatoid arthritis (RA) : role of the polymorphism at position-308 of the tumor-necrosis-factor alfa (TNFalpha) gene

  Biologie ostéo-articulaire🎓 Paris 7

  Direction : Jean Roudier

Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.

Bibliographie

• Prevention of aromatase inhibitor–induced bone loss with anti-resorptive therapy in post-menopausal women with early-stage breast cancer

  2023

  ArticleOsteoporosis International

• Impact of care pathway for nursing home residents treated for cancer: ONCO-EHPAD study

  2021

  ArticleSupportive Care in Cancer

• Impact of Androgen Deprivation Therapy Associated to Conformal Radiotherapy in the Treatment of D’Amico Intermediate-/High-Risk Prostate Cancer in Older Patients

  2021

  ArticleCancers

• Clinical effectiveness of osteoporosis treatment in older patients: A fracture liaison service-based prospective study

  2019

  ArticleJournal of Women and Aging

• Pathogenic bacteria and dead cells are internalized by a unique subset of Peyer's Patch dendritic cells that express lysozyme.

  2009

  ArticleGastroenterology

• Coronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signaling.

  2008

  ArticlePLoS ONE

• Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis.

  2007

  ArticleArthritis and Rheumatism

• Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis: Accurate quantification using real-time polymerase chain reaction

  2003

  ArticleArthritis and Rheumatism

Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).

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Top publications · les plus citées

• 1

  Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis

  Arthritis and rheumatism · 2003

  📚 179 citations🎯 RCR 4.39Top 9% NIH🩺 Clinique

  Lire l'abstract Crossref ↓

  Abstract Objective To test whether the G‐to‐A polymorphism at position −308 in the promoter of the tumor necrosis factor α (TNFα) gene influences response to infliximab therapy in patients with rheumatoid arthritis (RA). Methods We genotyped 59 RA patients by polymerase chain reaction and subdivided them into two groups: those with the A/A or A/G genotype and those with the G/G genotype. We compared the groups' clinical responses to infliximab treatment after 22 weeks, using the Disease Activity Score in 28 joints (DAS28). Results We found that 42% of patients in the A/A and A/G group and 81% of patients in the G/G group had improvement of at least 1.2 in the DAS28 score ( P = 0.0086). The average improvement in the DAS28 score was 1.24 in the A/A and A/G patients and 2.29 in the G/G patients ( P = 0.029). Conclusion These data suggest that patients with a TNFα −308G/G genotype are better infliximab responders than are patients with A/A or A/G genotypes. TNFα −308 genotyping may be a useful tool for predicting response to infliximab treatment.

• 2

  Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis: accurate quantification using real-time polymerase chain reaction

  Arthritis and rheumatism · 2003

  📚 147 citations🎯 RCR 3.25Top 14% NIH

  Lire l'abstract Crossref ↓

  AbstractObjectiveTo determine whether patients with rheumatoid arthritis (RA) have elevated Epstein‐Barr virus (EBV) load in their peripheral blood mononuclear cells (PBMCs) and whether it is correlated with the HLA–DR genes they express, we developed an accurate EBV DNA quantitative assay using real‐time polymerase chain reaction (PCR) with fluorescent probes.MethodsWe studied the EBV DNA load in the PBMCs of 84 patients with RA, 69 normal controls, and 22 patients with rheumatic conditions other than RA. A 214‐bp segment from the long internal repeat of EBV was amplified from 500 ng of PBMC DNA (150,000 cells) and quantified by real‐time PCR with fluorescent probes.ResultsWe demonstrated that in patients with RA, the EBV DNA load in PBMCs is increased almost 10‐fold compared with that in normal controls. The EBV load is stable over time and is not obviously influenced by disease‐modifying antirheumatic drugs or HLA–DR.ConclusionPatients with RA have elevated EBV load in their peripheral blood.

• 3

  Pathogenic bacteria and dead cells are internalized by a unique subset of Peyer's patch dendritic cells that express lysozyme

  Gastroenterology · 2010

  📚 94 citations🎯 RCR 2.11Top 25% NIH

Publications scientifiques (16) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

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