📇 Rhumatologue · FREJUS CEDEX · (83) · Salarié

M JEAN-PHILIPPE MARTINEZ

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Auteur de référence en rhumatologie
38 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
118.8 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 FREJUS CEDEX (83)SalariéRPPS 10003435558

📊 Reconnaissance scientifique : 9/100📝 34 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-α in lupus nephritis

Annals of the rheumatic diseases · 2018

📚 95 citations🎯 RCR 3.58Top 13% NIH

Remission of lupus nephritis: the trajectory of histological response in successfully treated patients

Lupus science & medicine · 2023

📚 32 citations🎯 RCR 4.12Top 10% NIH🔓 Open Access📄 PDF gratuit ↗

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ObjectiveThis study investigated changes in kidney histology over time in patients with lupus nephritis (LN) undergoing immunosuppressive treatment.MethodsPatients with proliferative±membranous LN were studied. After a diagnostic kidney biopsy (Bx1), patients had protocol biopsy 2 (Bx2) at 9 (6–15) months and protocol biopsy 3 (Bx3) at 42 (28–67) months. Kidney histological activity and chronicity indices (AI, CI) were measured.ResultsAI declined in a biphasic fashion, falling rapidly between Bx1 and Bx2 and then more slowly between Bx2 and Bx3. Patients were divided into those who achieved histological remission, defined as an AI=0 at Bx3 (group 1), and those with persistent histological activity (AI >0) at Bx3 (group 2). The early decline in AI was 1.6 times greater (95% CI 1.30, 1.91) in group 1 than group 2 (p=0.01). Between Bx2 and Bx3, the AI decline was 2.19-fold greater (95% CI 2.09, 2.29) in group 1 versus group 2 (p=7.34×10−5). Individual histological components of the AI resolved at different rates. Inflammatory lesions like glomerular crescents, karyorrhexis and necrosis mostly resolved by Bx2, whereas endocapillary hypercellularity, subendothelial hyaline deposits and interstitial inflammation resolved slowly, accounting for residual histological activity at biopsy 3 in group 2. In contrast, CI increased rapidly, by 0.15 units/month between Bx1 and Bx2, then plateaued. There were no differences in the rate of accumulation of chronic damage between group 1 and group 2. The increase in CI was significantly related to the severity of glomerular crescents (p=0.044), subendothelial hyaline deposits (p=0.002) and interstitial inflammation (p=0.015) at Bx1.ConclusionsLN histological activity takes months to years to resolve, providing a rationale for the need of long-term, well-tolerated maintenance immunosuppression. Despite responding, LN kidneys accrue chronic damage early during treatment. This finding provides an explanation for the association of chronic progressive kidney disease with recurrent episodes of LN.

Particulate ECM biomaterial ink is 3D printed and naturally crosslinked to form structurally-layered and lubricated cartilage tissue mimics

Biofabrication · 2022

📚 23 citations🎯 RCR 2.63Top 19% NIH

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Abstract Articular cartilage is a layered tissue with a complex, heterogeneous structure and lubricated surface which is challenging to reproduce using traditional tissue engineering methods. Three-dimensional printing techniques have enabled engineering of complex scaffolds for cartilage regeneration, but constructs fail to replicate the unique zonal layers, and limited cytocompatible crosslinkers exist. To address the need for mechanically robust, layered scaffolds, we developed an extracellular matrix particle-based biomaterial ink (pECM biomaterial ink) which can be extruded, polymerizes via disulfide bonding, and restores layered tissue structure and surface lubrication. Our cartilage pECM biomaterial ink utilizes functionalized hyaluronan (HA), a naturally occurring glycosaminoglycan, crosslinked directly to decellularized tissue particles (ø40–100 µ m). We experimentally determined that HA functionalized with thiol groups (t-HA) forms disulfide bonds with the ECM particles to form a 3D network. We show that two inks can be co-printed to create a layered cartilage scaffold with bulk compressive and surface (friction coefficient, adhesion, and roughness) mechanics approaching values measured on native cartilage. We demonstrate that our printing process enables the addition of macropores throughout the construct, increasing the viability of introduced cells by 10%. The delivery of these 3D printed scaffolds to a defect is straightforward, customizable to any shape, and adheres to surrounding tissue.

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M JEAN-PHILIPPE MARTINEZ

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Activité de recherche & publications

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (38) — classées par pathologie

Transversal21

Lupus4

Activité physique / Rééducation2

Épidémiologie & registres2

Essai clinique2

Biomarqueurs / Auto-Ac1

Fièvres auto-inflammatoires1

Gériatrie1

Qualité de vie / PROMs1

Recommandations1

Revue générale1

Risque cardio-vasculaire1

Santé mentale / fatigue1

Vraie vie / RWE1

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