📇 Rhumatologue · NANCY CEDEX · (54) · Mixte

M LOUIS MAILLARD

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5 raisons identifiées

Encadrant universitaire
Forme la prochaine génération de rhumatologues (6 thèses dirigées)
Praticien-chercheur
12 articles scientifiques publiés — formation continue solide
Expérience confirmée
17 ans d'exercice en rhumatologie — recul clinique solide
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
146.3 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 NANCY CEDEX (54)MixteRPPS 10002395811

EnseignementExpérience confirmée

17ans d'exercice (thèse 2009)

📊 Reconnaissance scientifique : 34/100📝 183 articles publiés🇫🇷 Publications académiques françaises (8)🎓 6 thèses dirigées

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Anticipatory anxiety of seizures is associated with ictal emotional distress and amygdala onset seizures

Epilepsia · 2022

📚 20 citations🎯 RCR 2.76Top 18% NIH

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AbstractObjectiveAnxiety disorders are a frequent psychiatric condition in patients with epilepsy. Anticipatory anxiety of seizures (AAS) is described as a daily persistent fear or excessive worry of having a seizure. AAS seems to be related to “subjective ictal anxiety” reported by patients. The current study aimed to assess the association between objective ictal features and the presence of AAS.MethodsNinety‐one patients with drug‐resistant focal epilepsy underwent a standardized psychiatric assessment, specific for epilepsy, and presurgical long‐term video‐electroencephalography (EEG) or stereo‐EEG (SEEG). We compared seizure semiology and epilepsy features of patients with AAS (n = 41) to those of patients without AAS (n = 50). We analyzed emotional and motor behavior ictal signs as well as ictal consciousness. We further assessed amygdala ictal involvement in seizures recorded with SEEG (n = 28).ResultsAAS was significantly associated with the presence of ictal emotional distress; negative emotional behavior (p < .01) and negative emotion were explicitly reported to the examiner during recording (p = .015), regardless of the ictal level of consciousness. Among the patients recorded with SEEG, we found a significant involvement of amygdala within the seizure onset zone (p < .01) for patients with AAS.SignificanceHigher risk of developing AAS is associated with seizures expressing negative emotional symptoms, independently of ictal consciousness level. Persistent interictal fear of seizures might be viewed as the consequence of a reinforcement of the emotional networks secondary to amygdala involvement in seizures of temporal origin. Physicians should screen for AAS not only to assess the impact of epilepsy on daily life, but also as an interictal biomarker of ictal semiology and emotional network involvement at seizure onset.

Stratifying sudden death risk in adults with drug-resistant focal epilepsy: The SUDEP-CARE score

European journal of neurology · 2023

📚 19 citations🎯 RCR 3.72Top 12% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractBackground and purposeA clinical risk score for sudden unexpected death in epilepsy (SUDEP) in patients with drug‐resistant focal epilepsy could help improve prevention.MethodsA case–control study was conducted including (i) definite or probable SUDEP cases collected by the French National Sentinel Mortality Epilepsy Network and (ii) control patients from the French national research database of epilepsy monitoring units. Patients with drug‐resistant focal epilepsy were eligible. Multiple logistic regressions were performed. After sensitivity analysis and internal validation, a simplified risk score was developed from the selected variables.ResultsSixty‐two SUDEP cases and 620 controls were included. Of 21 potential predictors explored, seven were ultimately selected, including generalized seizure frequency (>1/month vs. <1/year: adjusted odds ratio [AOR] 2.6, 95% confidence interval [CI] 1.25–5.41), nocturnal or sleep‐related seizures (AOR 4.49, 95% CI 2.68–7.53), current or past depression (AOR 2.0, 95% CI 1.19–3.34) or the ability to alert someone of an oncoming seizure (AOR 0.57, 95% CI 0.33–0.98). After internal validation, a clinically usable score ranging from −1 to 8 was developed, with high discrimination capabilities (area under the receiver operating curve 0.85, 95% CI 0.80–0.90). The threshold of 3 has good sensitivity (82.3%, 95% CI 72.7–91.8), whilst keeping a good specificity (82.7%, 95% CI 79.8–85.7).ConclusionsThese results outline the importance of generalized and nocturnal seizures on the occurrence of SUDEP, and show a protective role in the ability to alert someone of an oncoming seizure. The SUDEP‐CARE score is promising and will need external validation. Further work, including paraclinical explorations, could improve this risk score.

BDNF as potential biomarker of epilepsy severity and psychiatric comorbidity: pitfalls in the clinical population

Epilepsy research · 2023

📚 14 citations🎯 RCR 2.62Top 19% NIH🔓 Open Access

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M LOUIS MAILLARD

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Thèses universitaires

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Activité de recherche & publications

Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (12) — classées par pathologie

Transversal6

Biomarqueurs / Auto-Ac1

Épidémiologie & registres1

Essai clinique1

Génétique1

Pédiatrie1

Revue / méta-analyse1

Santé mentale / fatigue1

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