📇 Rhumatologue · CHALONS EN CHAMPAGNE CEDEX · (51) · Mixte

M HASAN MAHMOUD

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3 raisons identifiées

Auteur de référence en rhumatologie
31 articles scientifiques publiés — un praticien à la pointe de la recherche
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
134.8 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 CHALONS EN CHAMPAGNE CEDEX (51)MixteRPPS 10001744043

📊 Reconnaissance scientifique : 17/100📝 33 articles publiés

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

17 articles ont été cités au moins 17fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

h-index

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Preparation, Characterization, and Release Kinetics of Chitosan-Coated Nanoliposomes Encapsulating Curcumin in Simulated Environments

Molecules (Basel, Switzerland) · 2019

📚 68 citations🎯 RCR 4.60Top 9% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Curcumin, a natural polyphenol, has many biological properties, such as anti-inflammatory, antioxidant, and anti-carcinogenic properties, yet, its sensitivity to light, oxygen, and heat, and its low solubility in water renders its preservation and bioavailability challenging. To increase its bioaccessibility, we fabricated nanoliposomes and chitosan-coated nanoliposomes encapsulating curcumin, and we evaluated the systems in terms of their physicochemical characteristics and release profiles in simulated gastrointestinal mediums. Chitosan-coating enhanced the stability of nanoliposomes and slowed the release of curcumin in the simulated gastrointestinal (GI) environment. This study demonstrates that nanoliposomes and chitosan-coated nanoliposomes are promising carriers for poorly soluble lipophilic compounds with low oral bioavailability, such as curcumin.

Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells

Marine drugs · 2020

📚 56 citations🎯 RCR 4.21Top 10% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Current anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive anticancer agents that can surpass these limitations is a necessity. One such agent, curcumin, is a polyphenolic compound derived from turmeric, and has been widely investigated for its potential anti-inflammatory and anticancer effects over the last 40 years. However, the poor bioavailability of curcumin, caused by its low absorption, limits its clinical use. In order to solve this issue, in this study, curcumin was encapsulated in chitosan-coated nanoliposomes derived from three natural lecithin sources. Liposomal formulations were all in the nanometric scale (around 120 nm) and negatively charged (around −40 mV). Among the three lecithins, salmon lecithin presented the highest growth-inhibitory effect on MCF-7 cells (two times lower growth than the control group for 12 µM of curcumin and four times lower for 20 µM of curcumin). The soya and rapeseed lecithins showed a similar growth-inhibitory effect on the tumor cells. Moreover, coating nanoliposomes with chitosan enabled a higher loading efficiency of curcumin (88% for coated liposomes compared to 65% for the non-coated liposomes) and a stronger growth-inhibitory effect on MCF-7 breast cancer cells.

Influence of lecithin-lipid composition on physico-chemical properties of nanoliposomes loaded with a hydrophobic molecule

Colloids and surfaces. B, Biointerfaces · 2014

📚 42 citations🎯 RCR 2.09

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M HASAN MAHMOUD

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Top publications · les plus citées

Publications scientifiques (31) — classées par pathologie

Transversal27

Case report / série2

Biomarqueurs / Auto-Ac1

Épidémiologie & registres1

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