Docteur ANTOINE LEONARD

Rhumatologue

RPPS 10001943306

✨ Génération du profil synthétique IA en cours…

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Rhumatologie (SM)

📚 CES (Certificat d'Études Spéciales)

CES Rhumatologie

🎓 Diplômes

DE Docteur en médecine

Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.

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Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

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Top publications · les plus citées

Weekly intravenous methotrexate in the treatment of rheumatoid arthritis

Arthritis and rheumatism · 1982

📚 79 citations🎯 RCR 4.78Top 8% NIH

Intellectual disability: population-based estimates of the proportion attributable to maternal alcohol use disorder during pregnancy

Developmental medicine and child neurology · 2013

📚 50 citations🎯 RCR 2.24Top 23% NIH🔓 Open Access

Lire l'abstract Crossref ↓

Aim The aim of this study was to examine the association between maternal alcohol use disorder and intellectual disability in children.Method All mothers with an International Classification of Diseases (ICD) 9 and/or 10 alcohol‐related diagnosis, a proxy for alcohol use disorder, recorded on the Western Australian health, mental health, and drug and alcohol data sets were identified through the Western Australian Data Linkage Unit (n=5614 non‐Aboriginal; n=2912 Aboriginal). A comparison cohort of mothers without an alcohol‐related diagnosis was frequency matched on maternal age within maternal Aboriginal status and year of birth of their children. Linkage with the Western Australian Midwives Notification System (1983–2001) identified all births to these mothers (n=10 664 and 7907 respectively). Linkage to the Western Australian Intellectual Disability Database and Register of Developmental Anomalies identified cases of intellectual disability with no identified genetic origin (intellectual disability) (n=1487) and fetal alcohol syndrome (n=66). Odds ratios (ORs) and 95% confidence intervals (CIs) for intellectual disability were calculated using logistic regression incorporating generalized estimating equations and used to estimate population‐attributable fractions.Results At least 3.8% (95% CI 2.84–4.89%) of cases of intellectual disability could be avoided by preventing maternal alcohol use disorder: 1.3% (95% CI 0.81–1.86%) in non‐Aboriginal and 15.6% (95% CI 10.85–20.94%) in Aboriginal children. We observed a three‐fold increase in the adjusted odds of intellectual disability in children of mothers with an alcohol‐related diagnosis recorded during pregnancy (non‐Aboriginal OR 2.89, 95% CI 1.62–5.18; Aboriginal OR 3.12, 95% CI 2.13–4.56), with a net excess proportion of 3.7% and 5.5% respectively. One‐third (32%) of children diagnosed with fetal alcohol syndrome had intellectual disability.Interpretation Maternal alcohol use disorder is the leading known risk factor for intellectual disability with no identified genetic origin.

Racial Differences and Factors Associated with Pregnancy in ESKD Patients on Dialysis in the United States

Journal of the American Society of Nephrology : JASN · 2019

📚 44 citations🎯 RCR 2.97Top 16% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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Significance Statement Pregnancy is not common in women on dialysis due to impaired fertility. Literature is scarce about pregnancy in women on dialysis in the United States. In this retrospective study, the authors examined the pregnancy rates and associated factors in 47,555 US women on dialysis from 2005 to 2013. They identified 2352 pregnancies, for a rate of 17.8 per thousand person years, a higher rate than seen in previous studies. Pregnancy rates were highest in Native American women followed by Hispanics, blacks, Asians, and whites. Younger age, hemodialysis as the dialysis modality, and ESKD caused by GN, vasculitis, neoplasm, and hypertension were associated with the higher likelihood of pregnancy. Patients with diabetes as the cause of ESKD had the lowest pregnancy rates. This study improves our understanding of pregnancy in women on dialysis, and can lead to better counseling and shared decision making. Background Pregnancy in women with ESKD undergoing dialysis is uncommon due to impaired fertility. Data on pregnancy in women on dialysis in the United States is scarce. Methods We evaluated a retrospective cohort of 47,555 women aged 15–44 years on dialysis between January 1, 2005 and December 31, 2013 using data from the United States Renal Data System with Medicare as primary payer. We calculated pregnancy rates and identified factors associated with pregnancy. Results In 47,555 women on dialysis, 2352 pregnancies were identified. Pregnancy rate was 17.8 per thousand person years (PTPY) with the highest rate in women aged 20–24 (40.9 PTPY). In the adjusted time-to-event analysis, a higher likelihood of pregnancy was seen in Native American (HR, 1.77; 95% CI, 1.33 to 2.36), Hispanic (HR, 1.51; 95% CI, 1.32 to 1.73), and black (HR, 1.33; 95% CI, 1.18 to 1.49) women than in white women. A higher rate of pregnancy was seen in women with ESKD due to malignancy (HR, 1.64; 95% CI, 1.27 to 2.12), GN (HR, 1.38; 95% CI, 1.21 to 1.58), hypertension (HR, 1.32; 95% CI, 1.16 to 1.51), and secondary GN/vasculitis (HR, 1.18; 95% CI, 1.02 to 1.37) than ESKD due to diabetes. A lower likelihood of pregnancy was seen among women on peritoneal dialysis than on hemodialysis (HR, 0.47; 95% CI, 0.41 to 0.55). Conclusions The pregnancy rate is higher in women on dialysis than previous reports indicate. A higher likelihood of pregnancy was associated with race/ethnicity, ESKD cause, and dialysis modality.

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Publications scientifiques (20) — classées par pathologie

Transversal10

Goutte2

Sclérodermie2

csDMARDs1

Épidémiologie & registres1

Gériatrie1

Lupus1

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