Docteur Bastien LEGER
✨ Profil synthétique
IA · 07/05/2026Le Docteur Bastien LEGER est un rhumatologue hospitalier à Paris, avec une production scientifique significative dans le domaine de la recherche, comme en témoignent son h-index de 25 et ses 93 publications. Ses travaux de recherche couvrent divers sujets, allant de la catalyse à la santé et à la société. Ses publications sur PubMed se concentrent sur des cas cliniques, l'économie de la santé, la qualité de vie et la sclérodermie.
Expertises présumées
- Sclérodermie
- Évaluation de la qualité de vie
- Économie de la santé
- Médecine narrative
- Gestion de cas complexes
- Soins aux patients avec maladies chroniques
- Recherche en rhumatologie
Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.
Diplômes
🎓 DES & spécialité ordinale
- DES Rhumatologie
- Rhumatologie (SM)
🎓 Diplômes
- DE Docteur en médecine
Source : Annuaire Santé ANS (FHIR Practitioner.qualification) · Mises à jour quotidiennes.
Activité de recherche & publications
Source : bases de données publiques (OpenAlex, PubMed).
h-index
25
h articles cités ≥ h fois chacun. Un h de 25 = 25 publications avec 25+ citations.
Citations
1 618
Publications
93
i10-index
42
Thématiques principales
- Nanomaterials for catalytic reactions ×35
- Asymmetric Hydrogenation and Catalysis ×20
- Catalysis for Biomass Conversion ×19
- Health, Medicine and Society ×18
- Hermeneutics and Narrative Identity ×18
Affiliations FR : Centre National de la Recherche Scientifique · Université de Lille · Unité de catalyse et de chimie du solide de Lille
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Bibliographie
Reductive hydroformylation of methyl 10-undecenoate catalyzed by a rhodium/trialkylamine combination associated with silica: a new step towards a simple, robust and recyclable catalytic system
2026ArticleCatalysis Science & Technology
Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis
2025ArticleJournal of Bone and Mineral Research
Gold Nanoparticles Stabilized by δ‐Cyclodextrin in Aqueous Media: Characterization and Evaluation of their Catalytic Properties in the Reduction of 4‐Nitrophenol
2024ArticleChemNanoMat
Ion-Exchange Resin-Supported Ru NPs Dispersed in Randomly Methylated α-Cyclodextrin Aqueous Solution: A Step Toward an Efficient and Recyclable Catalyst for the Hydrogenation of Fatty Acid Methyl Esters and Derivatives
2024ArticleACS Sustainable Resource Management
Cyclodextrin-assisted hydrogenation of fatty acid methyl esters using ion-exchange resin-supported ruthenium nanoparticles
2023Congrès7<sup>th</sup> European Conference on Cyclodextrin (EuroCD 2023)
Hollow NiCo<sub>2</sub>O<sub>4</sub>−ZnO−Co<sub>3</sub>O<sub>4</sub>−/N−C micro-cage for synergistic bisphenol A degradation by activating persulfate
2023ArticleInorganic Chemistry
Catalytic Hydrogenation of derived-vegetable oils using ion-exchange resin-supported ruthenium nanoparticles
2023CongrèsGECAT 2023
Catalytic Hydrogenation of Derived Vegetable Oils Using Ion-Exchange Resin-Supported Ruthenium Nanoparticles: Scope and Limitations
2022ArticleACS Sustainable Chemistry & Engineering
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Lieu de consultation
GHU APHP NUP SITE BICHAT C BERNARD
46 Rue HENRI HUCHARD, 75877 Paris 18e Arrondissement
☎ 0140258080Hospitalier
Tarifs & secteur de conventionnement
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Prendre rendez-vous & contact
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Top publications · les plus citées
- 1Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse
British journal of pharmacology · 2020
Lire l'abstract Crossref ↓
Background and PurposeGenetic deletion and pharmacological studies suggest a role for lysophosphatidic acid (LPA1) receptor in fibrosis. We investigated the therapeutic potential in systemic sclerosis (SSc) of a new orally active selective LPA1 receptor antagonist using dermal fibroblasts from patients and an animal model of skin fibrosis.Experimental ApproachDermal fibroblast and skin biopsies from systemic sclerosis patients were used. Myofibroblast differentiation, gene expression and cytokine secretion were measured following LPA and/or SAR100842 treatment. Pharmacolgical effect of SAR100842 was assessed in the tight skin 1 (Tsk1) mouse model.Key ResultsSAR100842 is equipotent against various LPA isoforms. Dermal fibroblasts and skin biopsies from patients with systemic sclerosis expressed high levels of LPA1 receptor. The LPA functional response (Ca2+) in systemic sclerosis dermal fibroblasts was fully antagonized with SAR100842. LPA induced myofibroblast differentiation in systemic sclerosis dermal and idiopathic pulmonary fibrosis lung fibroblasts and the secretion of inflammatory markers and activated Wnt markers. Results from systemic sclerosis dermal fibroblasts mirror those obtained in a mouse Tsk1 model of skin fibrosis. Using a therapeutic protocol, SAR100842 consistently reversed dermal thickening, inhibited myofibroblast differentiation and reduced skin collagen content. Inflammatory and Wnt pathway markers were also inhibited by SAR100842 in the skin of Tsk1 mice.Conclusion and ImplicationsThe effects of SAR100842 on LPA‐induced inflammation and on mechanisms linked to fibrosis like myofibroblast differentiation and Wnt pathway activation indicate that LPA1 receptor activation plays a key role in skin fibrosis. Our results support the therapeutic potential of LPA1 receptor antagonists in systemic sclerosis.
- 2Supramolecular shuttle and protective agent: a multiple role of methylated cyclodextrins in the chemoselective hydrogenation of benzene derivatives with ruthenium nanoparticles
Chemical communications (Cambridge, England) · 2006
📚 27 citations
Publications scientifiques (21) — classées par pathologie
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Transversal17
▼
Transversal17
▼- Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026 · Journal Article
Ostertag A, Léger B, Koumakis E, Fardellone P, et al.
📚 1 cit. - Ankle retinacula abnormalities as features of psoriatic arthritis: An ultrasound study
Joint bone spine · 2024 · Journal Article
Forien M, Ebstein E, Léger B, Benattar L, et al.
📚 3 cit.🎯 RCR 1.61 - Hollow NiCo(2)O(4)-ZnO-Co(3)O(4)-/N-C Micro-Cage for Synergistic Bisphenol A Degradation by Activating Persulfate
Inorganic chemistry · 2023 · Journal Article
Wang J, Wang M, Leger B, Ponchel A, et al.
📚 1 cit. - Inadequate response to treatment reveals persistent osteoclast bone resorption in osteoporotic patients
Bone · 2021 · Journal Article
Léger B, Fardellone P, Cormier C, Ostertag A, et al.
📚 3 cit. - Synthesis of novel catalytic composite nanofibers containing ruthenium nanoparticles stabilized by a citric acid-β-cyclodextrin polymer
Nanoscale advances · 2020 · Journal Article
Fadlallah S, Tabary N, Noël S, Léger B, et al.
📚 1 cit. - Biphasic Palladium-Catalyzed Hydroesterification in a Polyol Phase: Selective Synthesis of Derived Monoesters
ChemSusChem · 2015 · Journal Article
Pruvost R, Boulanger J, Léger B, Ponchel A, et al.
📚 5 cit. - Synthesis of 1,4:3,6-dianhydrohexitols diesters from the palladium-catalyzed hydroesterification reaction
ChemSusChem · 2014 · Journal Article
Pruvost R, Boulanger J, Léger B, Ponchel A, et al.
📚 5 cit. - Carboxylated polymers functionalized by cyclodextrins for the stabilization of highly efficient rhodium(0) nanoparticles in aqueous phase catalytic hydrogenation
Dalton transactions (Cambridge, England : 2003) · 2012 · Journal Article
Noël S, Léger B, Herbois R, Ponchel A, et al.
📚 4 cit. - Cyclodextrins as growth controlling agents for enhancing the catalytic activity of PVP-stabilized Ru(0) nanoparticles
Chemical communications (Cambridge, England) · 2012 · Journal Article
Herbois R, Noël S, Léger B, Bai L, et al.
📚 6 cit. - N-donor ligands based on bipyridine and ionic liquids: an efficient partnership to stabilize rhodium colloids. Focus on oxygen-containing compounds hydrogenation
Physical chemistry chemical physics : PCCP · 2011 · Journal Article
Denicourt-Nowicki A, Léger B, Roucoux A
📚 4 cit. - Noncovalent functionalization of multiwall carbon nanotubes by methylated-β-cyclodextrins modified by a triazole group
Chemical communications (Cambridge, England) · 2010 · Journal Article
Léger B, Menuel S, Landy D, Blach JF, et al.
📚 8 cit. - Activated carbon as a mass-transfer additive in aqueous organometallic catalysis
Chemistry (Weinheim an der Bergstrasse, Germany) · 2010 · Journal Article
Kania N, Léger B, Fourmentin S, Monflier E, et al.
- Catalytically active nanoparticles stabilized by host-guest inclusion complexes in water
Chemical communications (Cambridge, England) · 2009 · Journal Article
Hubert C, Denicourt-Nowicki A, Roucoux A, Landy D, et al.
📚 14 cit. - Rhodium nanocatalysts stabilized by various bipyridine ligands in nonaqueous ionic liquids: influence of the bipyridine coordination modes in arene catalytic hydrogenation
Inorganic chemistry · 2008 · Journal Article
Léger B, Denicourt-Nowicki A, Olivier-Bourbigou H, Roucoux A
📚 26 cit. - Rhodium colloidal suspensions stabilised by poly-N-donor ligands in non-aqueous ionic liquids: preliminary investigation into the catalytic hydrogenation of arenes
ChemSusChem · 2008 · Journal Article
Léger B, Denicourt-Nowicki A, Olivier-Bourbigou H, Roucoux A
📚 9 cit. - Supramolecular shuttle and protective agent: a multiple role of methylated cyclodextrins in the chemoselective hydrogenation of benzene derivatives with ruthenium nanoparticles
Chemical communications (Cambridge, England) · 2006 · Journal Article
Nowicki A, Zhang Y, Léger B, Rolland JP, et al.
📚 27 cit. - Organic phase stabilization of rhodium nanoparticle catalyst by direct phase transfer from aqueous solution to room temperature ionic liquid based on surfactant counter anion exchange
Chemical communications (Cambridge, England) · 2005 · Journal Article
Mévellec V, Leger B, Mauduit M, Roucoux A
📚 25 cit.
Case report / série1
▼
Case report / série1
▼- Racemose neurocysticercosis with meningitis and infectious vasculitis: A case report
Revue neurologique · 2025 · Letter
Leger B, Chaugne E, Boudot de la Motte M, Boucenna M, et al.
📚 1 cit.
Économie santé1
▼
Économie santé1
▼- Burden of comorbidities: Osteoporotic vertebral fracture during non-small cell lung cancer - the BONE study
European journal of cancer (Oxford, England : 1990) · 2024 · Journal Article
Ebstein E, Brocard P, Soussi G, Khoury R, et al.
📚 4 cit.🎯 RCR 1.10
Qualité de vie / PROMs1
▼
Qualité de vie / PROMs1
▼- Development and internal-external cross-validation of a patient-reported definition for acute calcium pyrophosphate crystal arthritis
Rheumatology (Oxford, England) · 2025 · Journal Article
Cipolletta E, Rozza D, Andres M, Ottaviani S, et al.
📚 1 cit.
Sclérodermie1
▼
Sclérodermie1
▼- Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse
British journal of pharmacology · 2020 · Journal Article
Ledein L, Léger B, Dees C, Beyer C, et al.
📚 27 cit.🎯 RCR 1.54🔬→🩺 Translationnel