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DU Réparation du dommage corporelDU
Formation à l'expertise médicale dans les procédures juridiques (accidents du travail, AT/MP, indemnisation). Le rhumato expertise les conséquences fonctionnelles.
Plusieurs universités françaises
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
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📰 Le Berry Républicain · 01/12/2025
<a href="https://news.google.com/rss/articles/CBMi4AFBVV95cUxNVGVNVFZ1Ri00bXQxVU5TbWFscUU1ZnVUZEFtU3BaNUdxUkk0cHhtN0lTRzMtNzgwVWIzZ2JGWW9TcV9vQWF1NW1nX3ZlMGxLZjFrSTlpYXVNTlhnNDZ2VEQwQWY1QklFdy1CM3JkcDNwWUdHOVpxQXg3dk5SSmg4cmhnYUhTX0picW9GT0pFRkJFX1Rfd0hfZDlDeWpabU1yR1dGUk9tZlplaTJoRGcwUWc0X1hadVg0UE
📰 Radio-Canada · 15/12/2016
<a href="https://news.google.com/rss/articles/CBMingFBVV95cUxPa0x0ZDRXSHFhLTRKSUJoeWFYb0dBSWlVVUZhMEJETTVCZ2ExbGc0dU40Z0xRX2RsbFgxcFZsMUlWN0J0enNvSHBva0xiU0JKa3h6ZURhM1RmVXhxeU1jZ1dyOXlZQ0RheEVWcTJMaXpvdE5JUGprWEFmcFlSQTZoYTZXRjJKUmI1WGdsNW04a0hiWkpNY2ZQc1Z4bm1lUQ?oc=5" target="_blank">Camionneurs :
Lupus · 1997
Lupus nephritis results from the deposition on the glomerular basement membrane of antibodies cross-reacting with dsDNA. In an attempt to suppress the production of such antibodies in the MRLlpr mouse strain, mice were treated by injections of dsDNA-anti-dsDNA antibody complexes formed in an excess of syngeneic polyclonal antibodies to increase the immunogenicity of idiotypes. A first group of mice was treated after the onset of high-affinity anti-dsDNA IgG antibodies (3 months). We show here that fortnightly injections of dsDNA-anti-dsDNA antibody complexes significantly extend mouse survival over that of two control groups treated with either the carrier buffer or with sham complexes. Treated mice produced 5-fold less anti-dsDNA antibodies than control mice and presented a reduced nephritis activity index at the age of 7 months. Specific anti-idiotypic antibody levels were not modified in the treated group, while showing a sharp decrease in the control group between months 6 and 7. Mice of a second group were started on injections of dsDNA-anti-dsDNA complexes at the age of 4 months when nephritis was already ongoing, and were followed until death while receiving fortnightly injections. Forty percent of the treated mice were still alive after one year, while none of the control mice survived. dsDNA-anti-dsDNA complexes have therefore the potential of reducing the production of anti-dsDNA antibody production and the severity of nephritis in MRLlpr mice. These findings could be relevant for the treatment of human lupus.
Lupus · 1994
Antibodies towards double-strain (ds) DNA are responsible for the development of lupus nephritis both in human and animal models. A method by which one would suppress the production of pathogenic idiotypes could therefore prevent the development of nephritis. To this end, we prepared polyclonal anti-dsDNA antibodies by immunoaffinity from a serum pool of MRL/MpJ- lpr mice, a strain that develops an early form of nephritis identical to its human counterpart. Antigen-antibody complexes were prepared by addition of dsDNA. Such complexes have the potential of altering the anti-DNA antibody response and boosting the production of specific anti-idiotypic antibodies. Two groups of 14 MRL lpr mice were treated by regular intraperitoneal injections of 10μg dsDNA-anti-dsDNA complexes or carrier buffer, starting at the age of 4 weeks, namely, prior to the appearance of nephritogenic anti-dsDNA IgG antibodies. We show here that such a treatment significantly extended the survival of treated mice compared with the control group. Five treated mice were still alive at month 11 compared with two in the control group. In addition, microscopic kidney examination at the time of death showed less lesions in the treated group compared with controls. This study indicates that complexes made of dsDNA and anti-dsDNA can delay the development of nephritis in the MRL lpr mouse strain.
The European physical journal. C, Particles and fields · 2021
AbstractThe Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE’s sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach.
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The European physical journal. C, Particles and fields · 2022 · Journal Article
Abud AA, Abi B, Acciarri R, Acero MA, et al.
The European physical journal. C, Particles and fields · 2021 · Journal Article
Abi B, Acciarri R, Acero MA, Adamov G, et al.
Lupus · 1997 · Comparative Study
Burny W, Lebrun P, Cosyns JP, Saint-Remy JM
Lupus · 1994 · Journal Article
Lebrun P, Burny W, Cosyns JP, Saint-Remy JM