📇 Rhumatologue · PAU CEDEX · (64) · Hospitalier

MME IRINA LAZAR-BRAGA

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Auteur de référence en rhumatologie
25 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 PAU CEDEX (64)HospitalierRPPS 10100714756

✨ Génération du profil synthétique IA en cours…

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CENTRE HOSPITALIER DE PAU
4 BD HAUTERIVE BP 1156, 64046 PAU CEDEX
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Top publications · les plus citées

beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients

Stroke · 1999

📚 39 citations🎯 RCR 1.08

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Background and Purpose —This study was conducted to analyze the association between reported risk factors for Alzheimer’s disease, apolipoprotein E ε4 allele, and cardiovascular disease and neuropathological changes essential for the diagnosis of Alzheimer’s disease. Methods —Our data are based on clinical and postmortem evaluations of a cohort of nondemented (n=118) and demented (n=107) individuals. A cardiovascular index was calculated at autopsy to estimate the extent of cardiovascular disease. Neuropathological lesions such as senile/neuritic plaques, neurofibrillary tangles, β-amyloid load, cerebral amyloid angiopathy, and the load of paired helical filaments were determined. Results —The aforementioned neuropathological lesions did not show any positive significant correlation with cardiovascular index. In contrast, the extent of Alzheimer’s lesions was significantly higher in those nondemented and demented patients carrying the apolipoprotein E ε4 allele than in those without this allele. Conclusions —Our results demonstrate that the apolipoprotein E ε4 allele, but not cardiovascular disease, indeed influences the extent of Alzheimer’s lesions seen in the brain tissue of demented patients as well as asymptomatic controls.

Low Blood ALT Activity and High FRAIL Questionnaire Scores Correlate with Increased Mortality and with Each Other. A Prospective Study in the Internal Medicine Department

Journal of clinical medicine · 2018

📚 36 citations🎯 RCR 2.21Top 24% NIH🔓 Open Access📄 PDF gratuit ↗

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Background: Low blood ALT, Alanine aminotransferase activity and high FRAIL (Fatigue, Resistance, Ambulation, Illnesses and Loss of Weight) questionnaire scores were previously shown to be associated with frailty and increased risk of mortality. We aimed to correlate these tools with mortality and each other in patients hospitalized in an internal medicine department. Methods: This is a prospective study in a large tertiary hospital. We assessed the predictive value for clinical outcomes of both low ALT blood activity and the pre-frail and frail categories of the “FRAIL” questionnaire. Results: During a 15 months study, 179 consecutive patients were recruited, of whom 20 died. When all study participants were divided to three groups according to admission ALT levels (below 10 IU/L, 11 to 19 IU/L and above 20 IU/L) we found a statistically significant difference in the rate of mortality: 4 patients died within the group of ALT < 10 IU/L, 14 patients died in the group of 10 IU/L < ALT < 19 IU/L and in the group of patients with ALT > 20 IU/L, only 2 patients died (p = 0.042). A higher score on the FRAIL questionnaire was associated, with statistical significance, with higher risk of mortality (p = 0.029). There was a significant correlation (p = 0.038) between blood ALT activity and the pre-frailty and frailty classifications by the FRAIL Questionnaire. Conclusions: Both the FRAIL questionnaire and blood ALT activity are simple and practical tools for frailty assessment and risk stratification of patients hospitalized in the internal medicine department. Both tool’s results also correlate with each other.

The Effects of Intermittent Hypoxic-Hyperoxic Exposures on Lipid Profile and Inflammation in Patients With Metabolic Syndrome

Frontiers in cardiovascular medicine · 2021

📚 24 citations🎯 RCR 2.01🔓 Open Access📄 PDF gratuit ↗

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Background: Patients with metabolic syndrome (MS) tend to suffer from comorbidities, and are often simultaneously affected by obesity, dysglycemia, hypertension, and dyslipidemia. This syndrome can be reversed if it is timely diagnosed and treated with a combination of risk factors-reducing lifestyle changes and a tailored pharmacological plan. Interval hypoxic-hyperoxic training (IHHT) has been shown as an effective program in reducing cardiovascular risk factors in patients with MS even in the absence of exercise. However, the influence of IHHT on the lipid profile and inflammation in this clinical population remains relatively unknown.Methods: A prospective, single-center, randomized controlled trial was conducted on 65 (33 men) patients with MS aged 29–74 years, who were randomly allocated to the IHHT or control (sham) experimental groups. The IHHT group completed a 3-week, 5 days/week intermittent exposure to hypoxia and hyperoxia. The control (sham) group followed the same protocol but was breathing room air instead. The primary endpoints were the lipid profile (concentrations of total cholesterol [TC], low-density lipoprotein [LDL], high-density lipoprotein [HDL], and triglycerides [TG]) and the inflammatory factors such as high-sensitivity C-reactive protein (hs-CRP), galectin-3, heat shock proteins (Hsp70). The secondary endpoints were alanine aminotransferase (ALT), aspartate aminotransferase (AST), N-terminal pro-hormone of brain natriuretic peptide level (NTproBNP), transforming growth factor beta-1 (TGF-beta1), heart-type fatty acid-binding protein (H-FABP), and nitric oxide synthase 2 (NOS2).Results: There were no differences between the two groups but the different baseline values have affected these results. The IHHT group demonstrated pre-post decrease in total cholesterol (p = 0.001), LDL (p = 0.001), and TG levels (p = 0.001). We have also found a decrease in the CRP-hs (p = 0.015) and Hsp70 (p = 0.006) in IHHT-group after intervention, and a significant decrease in pre-post (delta) differences of NTproBNP (p &lt; 0.0001) in the IHHT group compared to the control group. In addition, the patients of the IHHT group showed a statistically significant decrease in pre-post differences of ALT and AST levels in comparison with the control group (p = 0.001). No significant IHHT complications or serious adverse events were observed.Conclusions: The IHHT appears to improve lipid profile and anti-inflammatory status. It is a safe, well-tolerated procedure, and could be recommended as an auxiliary treatment in patients suffering from MS, however, the experiment results were limited by the baseline group differences.Clinical Trial Registration:ClinicalTrials.gov, identifier [NCT04791397]. Evaluation of the effect of IHHT on vascular stiffness and elasticity of the liver tissue in patients with MS.

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MME IRINA LAZAR-BRAGA

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Top publications · les plus citées

Publications scientifiques (25) — classées par pathologie

Transversal11

Case report / série4

Pédiatrie4

Épidémiologie & registres1

Gériatrie1

Microbiote1

Pharmacovigilance1

Revue / méta-analyse1

Revue générale1

Risque cardio-vasculaire1

Sjögren1

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