📇 Rhumatologue · LA ROCHELLE · (17) · Libéral
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Délais de RDV courts dans la région
120.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR CHLOE LAMOTTE D INCAMPS
2 AVENUE DU 14 JUILLET, 17000 LA ROCHELLE
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
Abstract Iron overload is one of the secondary osteoporosis etiologies. Cellular and molecular mechanisms involved in iron‐related osteoporosis are not fully understood. Aim The aim of the study was to investigate the respective roles of iron excess and hepcidin, the systemic iron regulator, in the development of iron‐related osteoporosis. Material and Methods We used mice models with genetic iron overload (GIO) related to hepcidin deficiency ( Hfe −/− and Bmp6 −/− ) and secondary iron overload (SIO) exhibiting a hepcidin increase secondary to iron excess. Iron concentration and transferrin saturation levels were evaluated in serum and hepatic, spleen, and bone iron concentrations were assessed by ICP‐MS and Perl's staining. Gene expression was evaluated by quantitative RT‐PCR. Bone micro‐architecture was evaluated by micro‐CT. The osteoblastic MC3T3 murine cells that are able to mineralize were exposed to iron and/or hepcidin. Results Despite an increase of bone iron concentration in all overloaded mice models, bone volume/total volume (BV/TV) and trabecular thickness (Tb.Th) only decreased significantly in GIO, at 12 months for Hfe −/− and from 6 months for Bmp6 −/− . Alterations in bone microarchitecture in the Bmp6 −/− model were positively correlated with hepcidin levels (BV/TV ( ρ = +.481, p < .05) and Tb.Th ( ρ = +.690, p < .05). Iron deposits were detected in the bone trabeculae of Hfe −/− and Bmp6 −/− mice, while iron deposits were mainly visible in bone marrow macrophages in secondary iron overload. In cell cultures, ferric ammonium citrate exposure abolished the mineralization process for concentrations above 5 μM, with a parallel decrease in osteocalcin, collagen 1, and alkaline phosphatase mRNA levels. Hepcidin supplementation of cells had a rescue effect on the collagen 1 and alkaline phosphatase expression level decrease. Conclusion Together, these data suggest that iron in excess alone is not sufficient to induce osteoporosis and that low hepcidin levels also contribute to the development of osteoporosis.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023 · Journal Article
Robin F, Chappard D, Leroyer P, Latour C, et al.